In‐a‐dish: Induced pluripotent stem cells as a novel model for human diseases
Open accessAbstract
Human pluripotent stem cells bring promise in regenerative medicine due to their self‐renewing ability and the potential to become any cell type in the body. Moreover, pluripotent stem cells can produce specialized cell types that are affected in certain diseases, generating a new way to study cellular and molecular mechanisms involved in the disease pathology under the controlled conditions of a scientific laboratory. Thus, induced pluripotent stem cells (iPSC) are already being used to gain insights into the biological mechanisms of several human disorders. Here we review the use of iPSC as a novel tool for disease modeling in the lab. © 2012 International Society for Advancement of Cytometry
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Demonstration of disease-specific pathogenesis in complex and heterogeneous disease such as sporadic ASD is a current challenge.
“the demonstration of disease-specific pathogenesis in complex and heterogeneous disease such as sporadic ASD is a current challenge in the field23.”
From Altered proliferation and networks in neural cells derived from idiopathic autistic individuals (2017) · cites this paper as [23]
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Self-citation
- Authors
- Beltrão‐Braga, P. C. B., Pignatari, G. C., Russo, F. B., Fernandes, I. R., & Muotri, A. R.
- Affiliations
- Universidade de São Paulo (BR)
- Venue
- Cytometry Part A
- Publisher
- Wiley
- Published
- 2012-12-20
- Volume
- 83A
- Issue
- 1
- Pages
- 11-17
- ISSN
- 1552-4922 (ISSN-L)
- 1552-4930
- OpenAlex
- W2084143293
- Cited by
- 30
- References
- 79
- Citations by year
- 2025: 3 · 2023: 1 · 2022: 5 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 3
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cytometry Part A (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- induced pluripotent stem cells, disease modeling, human pluripotent stem cells, regenerative medicine, disease pathology, in vitro disease model
- MeSH terms
- Cell Differentiation, Humans, Models, Biological, Nervous System Diseases, Phenotype, Pluripotent Stem Cells, Cell Proliferation, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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