Whole-Genome Analysis of Histone H3 Lysine 4 and Lysine 27 Methylation in Human Embryonic Stem Cells
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By fine-tuning Geneformer using solely transcriptional data with only 56 labeled loci in ~15,000 ESCs, the model could predict the results of more recent studies that included genome-wide profiling of bivalent domains.
“Thus, by fine-tuning Geneformer using solely transcriptional data with only 56 labeled loci in ~15,000 ESCs, the model could predict the results of more recent studies30 that included genome-wide profiling of bivalent domains.”
From Transfer learning enables predictions in network biology (2023) · cites this paper as [30]
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- Authors
- Pan, G., Tian, S., Nie, J., Yang, C., Ruotti, V., Wei, H., Jonsdottir, G. A., Stewart, R., & Thomson, J. A.
- Affiliations
- University of Wisconsin–Madison (US)
- WiCell (US)
- Corresponding author
- Thomson, James A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 1
- Issue
- 3
- Pages
- 299-312
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2049598074
- Cited by
- 711
- References
- 2
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 10 · 2023: 30 · 2022: 16 · 2021: 35 · 2020: 21 · 2019: 25 · 2018: 19 · 2017: 35 · 2016: 35 · 2015: 43 · 2014: 51 · 2013: 60 · 2012: 72
- FWCI
- 23.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2146 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- histone H3 lysine 4 trimethylation, H3K27me3, H3K4me3, human embryonic stem cells, chromatin modification, Polycomb group proteins, trithorax group, pluripotency genes, SOX2, Oct4, Nanog
- MeSH terms
- Cell Differentiation, Gene Expression Regulation, Histones, Humans, Lysine, Methylation, Promoter Regions, Genetic, Genome, Human, Cell Lineage, Protein Transport, Embryonic Stem Cells
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