STRESSORS, SYMPTOM PROFILE, AND PREDICTORS OF ADJUSTMENT DISORDER IN CANCER PATIENTS. RESULTS FROM AN EPIDEMIOLOGICAL STUDY WITH THE COMPOSITE INTERNATIONAL DIAGNOSTIC INTERVIEW, ADAPTATION FOR ONCOLOGY (CIDI-O)
Open accessAbstract
BACKGROUND: We aimed to investigate type and frequency of stressors, predominant symptom profiles, and predictors of adjustment disorders (AD) in cancer patients across major tumor entities. METHODS: In this epidemiological study, we examined 2,141 cancer patients out of 4,020 screened with the Composite International Diagnostic Interview, adaptation for oncology (CIDI-O). AD were operationalized as subthreshold disorders according to DSM-IV criteria. RESULTS: In our sample, 265 out of 2,141 patients (12.4%) met all criteria for AD (unweighted 4-week prevalence). The disclosure of the cancer diagnosis, relapse or metastases, and cancer treatments were most frequently described as stressors associated with depressive or anxious symptoms. With regard to AD symptom profiles, patients showed high prevalence rates of affective symptoms according to the DSM-IV criteria of Major Depression: The highest prevalence rates were found for cognitive disturbances (concentration and memory problems) (88%), sleeping disturbances (86%), and depressive mood (83%). We found sex, education, and metastasis as significant predictors for AD. Higher education was the most influential predictor. Men were half as likely to report symptoms fulfilling the AD criteria as women. Patients with metastasized tumors had a more than 80% higher risk of AD than those without metastasis. However, the explained variance of our model is very small (Nagelkerke's R² = 0.08). CONCLUSIONS: Patients with AD can be identified using a standardized instrument and deserve clinical attention, as they often show severe clinical symptoms and impairments. Improving the clinical conceptualization of AD by the adding-on of potential stress-response-symptoms is necessary to identify severe psychological strain.
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The prevalence rate of 13-15% is in line with two previous studies reporting prevalence rates of 12%.
“The prevalence rate of 13–15% is in line with two previous studies reporting prevalence rates of 12% [4, 5].”
From Adjustment disorder in cancer patients after treatment: prevalence and acceptance of psychological treatment (2022) · cites this paper as [5]
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“In our study, women were significantly more likely to have probable AjD than men, consistent with previous reports [7, 10, 39, 40].”
- Authors
- Hund, B., Reuter, K., Härter, M., Brähler, E., Faller, H., Keller, M., Schulz, H., Wegscheider, K., Weis, J., Wittchen, H.-U., Koch, U., Friedrich, M., & Mehnert, A.
- Affiliations
- University Medical Center Freiburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital Leipzig (DE)
- University of Würzburg (DE)
- University Hospital Heidelberg (DE)
- University of Freiburg (DE)
- Institute of Clinical Psychology and Psychotherapy and Center of Clinical Epidemiology and Longitudinal Studies (CELOS); Technical University Dresden; Dresden Germany
- Corresponding author
- Mehnert, Anja
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2015-10-16
- Volume
- 33
- Issue
- 2
- Pages
- 153-161
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W2154222677
- Cited by
- 54
- References
- 28
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 5
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Krebshilfe (107465)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Keywords
- adjustment disorder, cancer patients, psychological stressors, symptom profiles, depressive symptoms, anxiety symptoms, cognitive disorders, sleep disorders, metastasis, sex differences, educational attainment, psychological strain
- MeSH terms
- Adjustment Disorders, Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Germany, Humans, Male, Middle Aged, Neoplasms, Psychiatric Status Rating Scales, Prevalence, Epidemiologic Studies, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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