Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys: J onge et al.
Open accessAbstract
CONTEXT: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population. OBJECTIVE: To present representative data about the cross-national epidemiology of PD and PAs in accordance with DSM-5 definitions. DESIGN AND SETTING: Nationally representative cross-sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3.0. PARTICIPANTS: Respondents (n = 142,949) from 25 high, middle, and lower-middle income countries across the world aged 18 years or older. MAIN OUTCOME MEASURES: PD and presence of single and recurrent PAs. RESULTS: Lifetime prevalence of PAs was 13.2% (SE 0.1%). Among persons that ever had a PA, the majority had recurrent PAs (66.5%; SE 0.5%), while only 12.8% fulfilled DSM-5 criteria for PD. Recurrent PAs were associated with a subsequent onset of a variety of mental disorders (OR 2.0; 95% CI 1.8-2.2) and their course (OR 1.3; 95% CI 1.2-2.4) whereas single PAs were not (OR 1.1; 95% CI 0.9-1.3 and OR 0.7; 95% CI 0.6-0.8). Cross-national lifetime prevalence estimates were 1.7% (SE 0.0%) for PD with a median age of onset of 32 (IQR 20-47). Some 80.4% of persons with lifetime PD had a lifetime comorbid mental disorder. CONCLUSIONS: We extended previous epidemiological data to a cross-national context. The presence of recurrent PAs in particular is associated with subsequent onset and course of mental disorders beyond agoraphobia and PD, and might serve as a generic risk marker for psychopathology.
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- Authors
- de Jonge, P., Roest, A. M., Lim, C. C. W., Florescu, S. E., Bromet, E. J., Stein, D. J., Harris, M., Nakov, V., Caldas-de-Almeida, J. M., Levinson, D., Al-Hamzawi, A. O., Haro, J. M., Viana, M. C., Borges, G., O'Neill, S., de Girolamo, G., Demyttenaere, K., Gureje, O., Iwata, N., Lee, S., Hu, C., Karam, A., Moskalewicz, J., Kovess-Masfety, V., Navarro-Mateu, F., Browne, M. O., Piazza, M., Posada-Villa, J., Torres, Y., ten Have, M. L., Kessler, R. C., & Scott, K. M.
- Affiliations
- Department of Psychiatry; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE); University Medical Center Groningen; University of Groningen; Groningen The Netherlands
- University Medical Center Groningen (NL)
- University of Otago (NZ)
- National School of Public Health, Management and Professional Development (RO)
- Stony Brook School (US)
- University of Cape Town (ZA)
- The University of Queensland (AU)
- National Center of Public Health and Analyses (BG)
- Chronic Diseases research Center (CEDOC) and Department of Mental Health; Faculdade de Ciencias Medicas; Universidade Nova de Lisboa; Lisboa Portugal
- Israel Ministry of Health (IL)
- University of Al-Qadisiyah (IQ)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Department of Social Medicine; Federal University of Espirito Santo; Brazil
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- School of Psychology; University of Ulster; Londonderry UK
- IRCCS Centro S. Giovanni di Dio Fatebenefratelli; Brescia Italy
- Universitair Ziekenhuis Leuven (BE)
- University of Ibadan (NG)
- Hiroshima International University (JP)
- Department of Psychiatry; The Chinese University of Hongkong; Hongkong China
- Peking University (CN)
- Institute for Development; Research; Advocacy and Applied Care (IDRAAC); Beirut Lebanon
- Institute of Psychiatry and Neurology (PL)
- Ecole des Hautes Estudies en Sante Pulbique; Paris Descartes University; Paris France
- Instituto Murciano de Investigación Biosanitaria (IMIB)-Arrixaca. Centro de Investigación Biomédica en Red. Epidemiología y Salud Pública (CIBERESP)-Murcia. Subdirección General de Salud Mental y Asistencia Psiquiátrica. Servicio Murciano de Salud; El Palmar (Murcia) Spain
- Centre for Mental Health; Melbourne School of Population and Global Health; University of Melbourne; Australia
- Universidad Peruana Cayetano Heredia (PE)
- El Bosque University; Bogota Colombia
- Universidad CES (CO)
- Trimbos Instituut; Netherlands Institute of Mental Health and Addiction; Utrecht Netherlands
- Harvard University (US)
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2016-10-24
- Volume
- 33
- Issue
- 12
- Pages
- 1155-1177
- ISSN
- 1091-4269 (ISSN-L)
- PMC
- PMC5143159
- OpenAlex
- W2543093936
- Cited by
- 229
- References
- 27
- Citations by year
- 2026: 21 · 2025: 32 · 2024: 21 · 2023: 32 · 2022: 35 · 2021: 26 · 2020: 22 · 2019: 15 · 2018: 17 · 2017: 7 · 2016: 1
- FWCI
- 18.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Ulster University Research Portal (Ulster University) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
- Repositorio Institucional Universidad El Bosque (submittedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Minerva Access (University of Melbourne) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Robert Wood Johnson Foundation (044708)
- John D. and Catherine T. MacArthur Foundation (R01 DA016558, R13-MH066849)
- John W. Alden Trust
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- World Health Organization
- F. Hoffmann-La Roche
- Public Health Agency
- ZonMw (91812607)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91812607;)
- Universidade de Lisboa
- Fundación para la Formación e Investigación Sanitarias de la Región de Murcia
- Servicio Murciano de Salud
- Fakultet Medicinskih Nauka, Univerziteta U Kragujevcu
- Servier
- H. Lundbeck A/S
- Fundação Champalimaud (R01 MH070884)
- Ministerio de Salud
- Ministerstwo Zdrowia
- National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05)
- Substance Abuse and Mental Health Services Administration
- Pfizer Foundation (R01‐MH069864, R01-DA016558, R13-MH066849, R03-TW006481)
- Pan American Health Organization
- Medical Research Council
- Fundação para a Ciência e a Tecnologia
- Consejería de Sanidad y Política Social, Comunidad Autónoma de la Región de Murcia
- National Institute of Mental Health (R13-MH-066849, R01‐MH070884, R01MH061905, R01MH059575, MH60220, MH070884, U01MH060220, R01‐MH069864)
- National Institute on Drug Abuse (R01DA016558)
- Fogarty International Center (FIRCA R03TW006481, R03TW006481)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- panic disorder, panic attacks, DSM-5 diagnostic criteria, comorbidities, age of onset, agoraphobia, World Mental Health Surveys
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Asia, Australia, Cross-Sectional Studies, Europe, Female, Health Surveys, Humans, Male, Mexico, Middle Aged, New Zealand, Nigeria, South America, United States, Prevalence, Panic Disorder, Internationality, Young Adult
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