Cited by 426Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesChild and Adolescent Psychosocial and Emotional DevelopmentMental Health Treatment and Access

The Age of Onset of Anxiety Disorders: A Meta-analysis

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Lijster, Jasmijn M. de, Dierckx, Bram, Utens, Elisabeth M.W.J., Verhulst, Frank C., Zieldorff, Carola, Dieleman, Gwen C., Legerstee, Jeroen S.·2017·The Canadian Journal of Psychiatry

Abstract

OBJECTIVE: The objective was to estimate the age of onset (AOO) for all anxiety disorders and for specific subtypes. Gender differences in the AOO of anxiety disorders were examined, as were the influence of study characteristics on reported AOOs. METHODS: Seven electronic databases were searched up to October 2014, with keywords representing anxiety disorder subtypes, AOO, and study design. The inclusion criteria were studies using a general population sample that provided data on the AOO for all anxiety disorders, or specific anxiety disorders, according to DSM-III-R, DSM-IV, or ICD-10 criteria. RESULTS: There were 1028 titles examined, which yielded 24 studies meeting the inclusion criteria. Eight studies reported the AOO and gender. Meta-analysis found a mean AOO of all anxiety disorders of 21.3 years (95% CI 17.46 to 25.07). Separation anxiety disorder, specific phobia, and social phobia had their mean onset before the age of 15 years, whereas the AOO of agoraphobia, obsessive-compulsive disorder, posttraumatic stress disorder, panic disorder, and generalized anxiety disorder began, on average, between 21.1 and 34.9 years. Meta-analysis revealed no difference in the AOO between genders. A prospective study design and higher developmental level of the study country were associated with an earlier AOO. CONCLUSIONS: Results from this meta-analysis indicate that anxiety disorder subtypes differ in the mean AOO, with onsets ranging from early adolescence to young adulthood. These findings suggest that prevention strategies of anxiety disorders should be directed towards factors associated with the development of anxiety disorder subtypes in the age groups with the greatest vulnerability for developing those disorders.

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  1. [18]18. clinical features and vulnerability factors. J Psychiatr Res. 2011;45(1):111-120.

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Authors
Lijster, J. M. D., Dierckx, B., Utens, E. M. W. J., Verhulst, F. C., Zieldorff, C., Dieleman, G. C., & Legerstee, J. S.
Affiliations
Erasmus MC - Sophia Children’s Hospital (NL)
Corresponding author
Legerstee, Jeroen S.
Venue
The Canadian Journal of Psychiatry
Published
2016-03-24
Volume
62
Issue
4
Pages
237-246
ISSN
  • 0706-7437 (ISSN-L)
  • 1497-0015
OpenAlex
W2329475114
Cited by
426
References
98
Citations by year
2026: 41 · 2025: 59 · 2024: 61 · 2023: 61 · 2022: 49 · 2021: 60 · 2020: 48 · 2019: 27 · 2018: 15 · 2017: 4 · 2016: 1
FWCI
22.24
Type
journal article
Language
en
Open access
Locations
  • The Canadian Journal of Psychiatry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
anxiety disorders, age of onset, gender differences, separation anxiety disorder, specific phobia, social anxiety disorder, agoraphobia, obsessive-compulsive disorder, post-traumatic stress disorder, panic disorder, generalized anxiety disorder, anxiety prevention
MeSH terms
Anxiety Disorders, Humans, Age of Onset

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