The Age of Onset of Anxiety Disorders: A Meta-analysis
Open accessAbstract
OBJECTIVE: The objective was to estimate the age of onset (AOO) for all anxiety disorders and for specific subtypes. Gender differences in the AOO of anxiety disorders were examined, as were the influence of study characteristics on reported AOOs. METHODS: Seven electronic databases were searched up to October 2014, with keywords representing anxiety disorder subtypes, AOO, and study design. The inclusion criteria were studies using a general population sample that provided data on the AOO for all anxiety disorders, or specific anxiety disorders, according to DSM-III-R, DSM-IV, or ICD-10 criteria. RESULTS: There were 1028 titles examined, which yielded 24 studies meeting the inclusion criteria. Eight studies reported the AOO and gender. Meta-analysis found a mean AOO of all anxiety disorders of 21.3 years (95% CI 17.46 to 25.07). Separation anxiety disorder, specific phobia, and social phobia had their mean onset before the age of 15 years, whereas the AOO of agoraphobia, obsessive-compulsive disorder, posttraumatic stress disorder, panic disorder, and generalized anxiety disorder began, on average, between 21.1 and 34.9 years. Meta-analysis revealed no difference in the AOO between genders. A prospective study design and higher developmental level of the study country were associated with an earlier AOO. CONCLUSIONS: Results from this meta-analysis indicate that anxiety disorder subtypes differ in the mean AOO, with onsets ranging from early adolescence to young adulthood. These findings suggest that prevention strategies of anxiety disorders should be directed towards factors associated with the development of anxiety disorder subtypes in the age groups with the greatest vulnerability for developing those disorders.
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The anxiety and stress scores are still below the community prevalence of generalized anxiety disorder and panic disorder.
“the anxiety and stress scores are still below the community prevalence of generalized anxiety disorder and panic disorder [74].”
From Relationships between psychopathology, psychological process variables, and sociodemographic variables and comparison of quarantined and non-quarantined groups of malaysian university students in the covid-19 pandemic (2021) · cites this paper as [74]
The Limitations passage says community surveys find anxiety disorders common, while the Meta-analyses passage reports ages of onset for generalized anxiety disorder and panic disorder. Neither gives community prevalence for those disorders or compares it with anxiety and stress scores (searched for subtype prevalence and symptom-score comparisons). (LLM, conf=0.75)
Experimental — accuracy not yet measured75% of psychiatric disorders begin before 24 years; median age of onset for anxiety is around 11-15 years; 10% of adolescents begin to experience recurrent major depression before 17 years.
“However, 75% of psychiatric disorders begin before 24 years95.”
From Decentering as a core component in the psychological treatment and prevention of youth anxiety and depression: a narrative review and insight report (2021) · cites this paper as [96]
The Meta-analyses section reports mean ages of onset for anxiety disorders, but not the proportion of all psychiatric disorders beginning before age 24. Searches for the 75% figure and its equivalent wording found no passage in our copy that establishes the cited sentence. (LLM, conf=0.72)
Experimental — accuracy not yet measured
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“However, the anxiety and stress scores are still below the community prevalence of generalized anxiety disorder and panic disorder [74].”
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“GAD is more commonly diagnosed in women at a ratio of 3:2 [16], with a mean age at onset of 21 [17].”
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- Authors
- Lijster, J. M. D., Dierckx, B., Utens, E. M. W. J., Verhulst, F. C., Zieldorff, C., Dieleman, G. C., & Legerstee, J. S.
- Affiliations
- Erasmus MC - Sophia Children’s Hospital (NL)
- Corresponding author
- Legerstee, Jeroen S.
- ORCID
- Venue
- The Canadian Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2016-03-24
- Volume
- 62
- Issue
- 4
- Pages
- 237-246
- ISSN
- 0706-7437 (ISSN-L)
- 1497-0015
- PMC
- PMC5407545
- OpenAlex
- W2329475114
- Cited by
- 426
- References
- 98
- Citations by year
- 2026: 41 · 2025: 59 · 2024: 61 · 2023: 61 · 2022: 49 · 2021: 60 · 2020: 48 · 2019: 27 · 2018: 15 · 2017: 4 · 2016: 1
- FWCI
- 22.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Canadian Journal of Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- anxiety disorders, age of onset, gender differences, separation anxiety disorder, specific phobia, social anxiety disorder, agoraphobia, obsessive-compulsive disorder, post-traumatic stress disorder, panic disorder, generalized anxiety disorder, anxiety prevention
- MeSH terms
- Anxiety Disorders, Humans, Age of Onset
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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