The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Plasticity in the developing brain: Implications for rehabilitation
Open accessAbstract
Neuronal plasticity allows the central nervous system to learn skills and remember information, to reorganize neuronal networks in response to environmental stimulation, and to recover from brain and spinal cord injuries. Neuronal plasticity is enhanced in the developing brain and it is usually adaptive and beneficial but can also be maladaptive and responsible for neurological disorders in some situations. Basic mechanisms that are involved in plasticity include neurogenesis, programmed cell death, and activity‐dependent synaptic plasticity. Repetitive stimulation of synapses can cause long‐term potentiation or long‐term depression of neurotransmission. These changes are associated with physical changes in dendritic spines and neuronal circuits. Overproduction of synapses during postnatal development in children contributes to enhanced plasticity by providing an excess of synapses that are pruned during early adolescence. Clinical examples of adaptive neuronal plasticity include reorganization of cortical maps of the fingers in response to practice playing a stringed instrument and constraint‐induced movement therapy to improve hemiparesis caused by stroke or cerebral palsy. These forms of plasticity are associated with structural and functional changes in the brain that can be detected with magnetic resonance imaging, positron emission tomography, or transcranial magnetic stimulation (TMS). TMS and other forms of brain stimulation are also being used experimentally to enhance brain plasticity and recovery of function. Plasticity is also influenced by genetic factors such as mutations in brain‐derived neuronal growth factor. Understanding brain plasticity provides a basis for developing better therapies to improve outcome from acquired brain injuries. © 2009 Wiley‐Liss, Inc. Dev Disabil Res Rev 2009;15:94–101.
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“…present study, our goal was to explore ways in which it might be possible to activate and “repair” a specific neural circuit in the mirror neuron system by assessing its mechanisms of action and language function recovery via hand motion observation training (Buccino et al., 2006; Johnston, 2009).”
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Nested Learning: The Illusion of Deep Learning Architectures
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“Human brain is highly efficient and effective when it comes to continual learning (a.k.a. effective context management), which is often attributed to neuroplasticity—the brain’s remarkable capacity to change itself in response to new experiences, memories, learning, and even damage [46, 47].”
Metadata
- Authors
- Johnston, M. V.
- Venue
- Developmental Disabilities Research Reviews
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 15
- Issue
- 2
- Pages
- 94-101
- ISSN
- 1940-5510 (ISSN-L)
- 1940-5529
- OpenAlex
- W2013848047
- Cited by
- 534
- References
- 15
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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