Cited by 24Prenatal Substance Exposure EffectsEpigenetics and DNA MethylationBirth, Development, and Health

Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning

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Boschen, K.E., Keller, S.M., Roth, T.L., Klintsova, A.Y.·2018·Neurotoxicology and Teratology

Abstract

The long-term effects of developmental alcohol and stress exposure are well documented in both humans and non-human animal models. Damage to the brain and attendant life-long impairments in cognition and increased risk for psychiatric disorders are debilitating consequences of developmental exposure to alcohol and/or psychological stress. Here we discuss evidence for a role of epigenetic mechanisms in mediating these consequences. While we highlight some of the common ways in which stress or alcohol impact the epigenome, we point out that little is understood of the epigenome's response to experiencing both stress and alcohol exposure, though stress is a contributing factor as to why women drink during pregnancy. Advancing our understanding of this relationship is of critical concern not just for the health and well-being of individuals directly exposed to these teratogens, but for generations to come.

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Crossref · 10.1016/j.ntt.2017.12.009

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  • The extent of paternal alcoholism has been associated with neurological and behavioral deficits in offspring.

    “The extent of paternal alcoholism has also been associated with neurological and behavioral deficits in offspring 198”

    From Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms (2018) · cites this paper as [198]

    The Multigenerational Effects section (page unavailable) reports behavioral abnormalities in offspring following paternal alcohol exposure. It does not establish an association with the extent of paternal alcoholism or specifically report neurological deficits in those offspring; the neurological and cognitive deficits discussed in the Prenatal Alcohol Exposure section concern prenatal exposure rather than paternal drinking. (LLM, conf=0.86)

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  1. Todkar A Granholm L Aljumah M Nilsson KW Comasco E Nylander I 2016 HPA axis gene expression and DNA methylation profiles in rats exposed to early life stress, adult voluntary ethanol drinking and single housing Frontiers in Molecular Neuroscience 8 90 26858597 PMC4726785

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Authors
Boschen, K. E., Keller, S. M., Roth, T. L., & Klintsova, A. Y.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • University of Delaware (US)
Corresponding author
  • Roth, T.L.
  • Klintsova, A.Y.
Venue
Neurotoxicology and Teratology
Publisher
Elsevier BV
Published
2018-03
Volume
66
Pages
63-79
ISSN
0892-0362 (ISSN-L)
OpenAlex
W2781538616
Cited by
24
References
293
Citations by year
2026: 3 · 2025: 2 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 1
FWCI
0.67
Type
journal article
Language
en
Open access
Locations
  • Neurotoxicology and Teratology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (P20GM103653)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD087509)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
epigenetics, developmental alcohol exposure, prenatal alcohol exposure, psychological stress, adversity, neurobehavioral function, cognitive impairment, mental illness, epigenome, teratogens, intergenerational effects
MeSH terms
Ethanol, Animals, Mental Disorders, Brain, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Maternal Exposure, DNA Methylation, Epigenesis, Genetic

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