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Early‐life stress leads to sex‐dependent changes in pubertal timing in rats that are reversed by a probiotic formulation

Cowan, Caitlin S. M., Richardson, Rick·2019·Developmental Psychobiology
DOI 10.1002/dev.21765
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Abstract

Puberty marks the beginning of a period of dramatic physical, hormonal, and social change. This instability has made adolescence infamous as a time of “storm and stress” and it is well‐established that stress during adolescence can be particularly damaging. However, prior stress may also shape the adolescent experience. In the present series of experiments, we observed sex‐specific effects of early‐life maternal separation stress on the timing of puberty onset in the rat. Specifically, stressed females exhibited earlier pubertal onset compared to standard‐reared females, whereas stressed males matured later than their standard‐reared counterparts. Further, we demonstrated that a probiotic treatment restores the normative timing of puberty onset in rodents of both sexes. These results are in keeping with previous findings that probiotics reverse stress‐induced changes in learned fear behaviors and stress hormone levels, highlighting the remarkable and wide‐ranging restorative effects of probiotics in the context of early‐life stress.

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  • The amygdala, hippocampus, and PFC are all modulated by changes in the microbiota.

    “and these brain regions are all modulated by changes in the microbiota (Bercik et al., 2011a;Clarke et al., 2013;Cowan et al., 2018;Gacias et al., 2016;Hoban et al., 2017;Hoban et al., 2016b;Luczynski et al., 2016b;Neufeld et al., 2011;Ogbonnaya et al., 2015;Stilling et al., 2015).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Cowan et al., 2018

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Authors
Cowan, C. S. M., & Richardson, R.
Affiliations
School of Psychology The University of New South Wales Sydney Australia
ORCID
Venue
Developmental Psychobiology
Publisher
Wiley
Published
2018-07-24
Volume
61
Issue
5
Pages
679-687
ISSN
  • 0012-1630
  • 1098-2302
DOI
10.1002/dev.21765
Cited by
52
References
9
Language
en
Licence
Funders
  • Australian Research Council (DP150104835)
  • University of New South Wales
  • National Health and Medical Research Council (APP1031688)
  • Petre Foundation

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