Cited by 64Resilience and Mental HealthChild Abuse and TraumaMaternal Mental Health During Pregnancy and Postpartum

Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity

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Kentner, Amanda C., Cryan, John F., Brummelte, Susanne·2019·Developmental Psychobiology

Abstract

Despite the increasing attention to early life adversity and its long‐term consequences on health, behavior, and the etiology of neurodevelopmental disorders, our understanding of the adaptations and interventions that promote resiliency and rescue against such insults are underexplored. Specifically, investigations of the perinatal period often focus on negative events/outcomes. In contrast, positive experiences (i.e. enrichment/parental care//healthy nutrition) favorably influence development of the nervous and endocrine systems. Moreover, some stressors result in adaptations and demonstrations of later‐life resiliency. This review explores the underlying mechanisms of neuroplasticity that follow some of these early life experiences and translates them into ideas for interventions in pediatric settings. The emerging role of the gut microbiome in mediating stress susceptibility is also discussed. Since many negative outcomes of early experiences are known, it is time to identify mechanisms and mediators that promote resiliency against them. These range from enrichment, quality parental care, dietary interventions and those that target the gut microbiota.

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  1. Harlow H.H. M, 1965 The affectional system In: Behavior of nonhuman primates. Vol. 2, A.H. Schrier H; Stollnitz F, ed.^eds. Academic Press, New York, pp. 287– 334.
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Authors
Kentner, A. C., Cryan, J. F., & Brummelte, S.
Affiliations
  • Massachusetts College of Pharmacy and Health Sciences (US)
  • University College Cork (IE)
  • Wayne State University (US)
Corresponding author
Kentner, Amanda C.
Venue
Developmental Psychobiology
Publisher
Wiley
Published
2018-10-11
Volume
61
Issue
3
Pages
350-375
ISSN
  • 0012-1630 (ISSN-L)
  • 1098-2302
OpenAlex
W2896650325
Cited by
64
References
374
Citations by year
2026: 2 · 2025: 9 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 17 · 2018: 1
FWCI
1.52
Type
journal article
Language
en
Open access
Locations
  • Developmental Psychobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Cork Open Research Archive (University College Cork, Ireland) (acceptedVersion)
  • Arrow@dit (Dublin Institute of Technology) (submittedVersion)
Funders
  • National Institute of Mental Health (R15MH114035)
  • Science Foundation Ireland (SFI/12/RC/2273)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
resilience, childhood adversity, perinatal period, neuroplasticity, enrichment, parental care, dietary intervention, gut microbiota, stress vulnerability, neurodevelopmental disorders, endocrine system development
MeSH terms
Gastrointestinal Microbiome, Adverse Childhood Experiences, Adaptation, Psychological, Humans, Neuronal Plasticity, Stress, Psychological, Resilience, Psychological

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