Resilience priming: Translational models for understanding resiliency and adaptation to early life adversity
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Despite the increasing attention to early life adversity and its long‐term consequences on health, behavior, and the etiology of neurodevelopmental disorders, our understanding of the adaptations and interventions that promote resiliency and rescue against such insults are underexplored. Specifically, investigations of the perinatal period often focus on negative events/outcomes. In contrast, positive experiences (i.e. enrichment/parental care//healthy nutrition) favorably influence development of the nervous and endocrine systems. Moreover, some stressors result in adaptations and demonstrations of later‐life resiliency. This review explores the underlying mechanisms of neuroplasticity that follow some of these early life experiences and translates them into ideas for interventions in pediatric settings. The emerging role of the gut microbiome in mediating stress susceptibility is also discussed. Since many negative outcomes of early experiences are known, it is time to identify mechanisms and mediators that promote resiliency against them. These range from enrichment, quality parental care, dietary interventions and those that target the gut microbiota.
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Individuals with a history of general ELA (as opposed to physical or sexual) may be more likely to translate these experiences into adulthood resiliency, which may explain the potentially protective nature of these experiences.
“Individuals with a history of general ELA (as opposed to physical or sexual) may be more likely to translate these experiences into adulthood resiliency, which may explain the potentially protective nature of these experiences 103.”
From History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity (2019) · cites this paper as [103]
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Pineda, R. G., Guth, R. M., Herring, A. A., Reynolds, L., Oberle, S., & Smith, J. (2016) · Journal of Perinatology · doi:10.1038/jp.2016.179 · Cited by 157 · see citing works
Beneficial effects of enriched environment on adolescent rats from stressed pregnancies.
Laviola, G., Rea, M., Morley‐Fletcher, S., Di Carlo, S., Bacosi, A., De Simone, R., Bertini, M., & Pacifici, R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03597.x · Cited by 155 · see citing works
Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques
Kinnally, E. L., Capitanio, J. P., Leibel, R., Deng, L., LeDuc, C., Haghighi, F., & Mann, J. J. (2010) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00588.x · Cited by 155 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
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Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Self-citationEarly environmental influences on the development of children's brain structure and function
Miguel, P. M., Pereira, L. O., Silveira, P. P., & Meaney, M. J. (2019) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14182 · Cited by 358 · see citing works
The future of rodent models in depression research
Gururajan, A., Reif, A., Cryan, J. F., & Slattery, D. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0221-6 · Cited by 269 · see citing works
Self-citationGutted! Unraveling the Role of the Microbiome in Major Depressive Disorder
Bastiaanssen, T. F. S., Cussotto, S., Claesson, M. J., Clarke, G., Dinan, T. G., & Cryan, J. F. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000243 · Cited by 159 · see citing works
Self-citationZhang, K., Sakamoto, A., Chang, L., Qu, Y., Wang, S., Pu, Y., Tan, Y., Wang, X., Fujita, Y., Ishima, T., et al. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01092-z · Cited by 63 · see citing works
Osadchiy, V., Mayer, E. A., Bhatt, R., Labus, J. S., Gao, L., Kilpatrick, L. A., Liu, C., Tillisch, K., Naliboff, B., Chang, L., et al. (2019) · Obesity Science & Practice · doi:10.1002/osp4.362 · Cited by 44 · see citing works
- Authors
- Kentner, A. C., Cryan, J. F., & Brummelte, S.
- Affiliations
- Massachusetts College of Pharmacy and Health Sciences (US)
- University College Cork (IE)
- Wayne State University (US)
- Corresponding author
- Kentner, Amanda C.
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2018-10-11
- Volume
- 61
- Issue
- 3
- Pages
- 350-375
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- PMC
- PMC6447439
- OpenAlex
- W2896650325
- Cited by
- 64
- References
- 374
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 9 · 2019: 17 · 2018: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (acceptedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Funders
- National Institute of Mental Health (R15MH114035)
- Science Foundation Ireland (SFI/12/RC/2273)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- resilience, childhood adversity, perinatal period, neuroplasticity, enrichment, parental care, dietary intervention, gut microbiota, stress vulnerability, neurodevelopmental disorders, endocrine system development
- MeSH terms
- Gastrointestinal Microbiome, Adverse Childhood Experiences, Adaptation, Psychological, Humans, Neuronal Plasticity, Stress, Psychological, Resilience, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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