The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Pre‐ and postnatal choline supplementation produces long‐term facilitation of spatial memory
Abstract
Although research has demonstrated that short‐term improvement in memory function of adult rats can occur when the availability of precursors for the neurotransmitter acetylcholine is increased, little is known about whether memory function of adult rats can be permanently altered by precursor supplementation during early development. In the present study, male albino rats were exposed to choline chloride supplementation both prenatally (through the diet of pregnant rats) and postnatally (subcutaneous injections). At 60 days of age rats were tested on a 12‐ and 18‐arm radial maze task. Results indicated that compared to control littermates, perinatal choline‐treated rats showed more accurate performance on both working and reference memory components of the task. Theis performance difference was apparent on the first block of sessions and continued throughout training. Further analysis revealed that the difference between choline and control rats is not due to use of differntaial response or cue‐use strategies. Instead, it appears that choline induced performance differences are due to long‐term enhancement of spatial memory capactiy and precision.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hippocampus, space, and memory
Olton, D. S., Becker, J. T., & Handelmann, G. E. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00062713 · Cited by 2,018
Remembrance of places passed: Spatial memory in rats.
Olton, D. S., & Samuelson, R. J. (1976) · Journal of Experimental Psychology: Animal Behavior Processes · doi:10.1037//0097-7403.2.2.97 · Cited by 1,998
Bartus, R. T., Dean, R. L., Sherman, K. A., Friedman, E., & Beer, B. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90007-5 · Cited by 140
Cited by
Choline: Critical Role During Fetal Development and Dietary Requirements in Adults
Zeisel, S. H. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111156 · Cited by 741
Choline, an essential nutrient for humans
Zeisel, S. H., Da Costa, K., Franklin, P. D., Alexander, E. A., Lamont, J. T., Sheard, N. F., & Beiser, A. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.7.2010061 · Cited by 622
Organizational effects of early gonadal secretions on sexual differentiation in spatial memory.
Williams, C. L., Barnett, A. M., & Meck, W. H. (1990) · Behavioral Neuroscience · doi:10.1037//0735-7044.104.1.84 · Cited by 532
Self-citationNiculescu, M. D., Craciunescu, C. N., & Zeisel, S. H. (2006) · The FASEB Journal · doi:10.1096/fj.05-4707com · Cited by 330
Meck, W. H., & Williams, C. L. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00069-1 · Cited by 323
Self-citation
Metadata
- Authors
- Meck, W. H., Smith, R. A., & Williams, C. L.
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 1988-05
- Volume
- 21
- Issue
- 4
- Pages
- 339-353
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- OpenAlex
- W2116467526
- Cited by
- 268
- References
- 3
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Pre‐ and postnatal choline supplementation produces long‐term facilitation of spatial memory. https://app.cochat.ai/papers/10.1002/dev.420210405
- The paper
- Meck, W. H., Smith, R. A., & Williams, C. L. (1988). Pre‐ and postnatal choline supplementation produces long‐term facilitation of spatial memory. Developmental Psychobiology. https://doi.org/10.1002/dev.420210405
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
