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Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management
Open accessAbstract
The Cardiovascular Autonomic Neuropathy (CAN) Subcommittee of the Toronto Consensus Panel on Diabetic Neuropathy worked to update CAN guidelines, with regard to epidemiology, clinical impact, diagnosis, usefulness of CAN testing, and management. CAN is the impairment of cardiovascular autonomic control in the setting of diabetes after exclusion of other causes. The prevalence of confirmed CAN is around 20%, and increases up to 65% with age and diabetes duration. Established risk factors for CAN are glycaemic control in type 1 and a combination of hypertension, dyslipidaemia, obesity, and glycaemic control in type 2 diabetes. CAN is a risk marker of mortality and cardiovascular morbidity, and possibly a progression promoter of diabetic nephropathy. Criteria for CAN diagnosis and staging are: (1) one abnormal cardiovagal test result identifies possible or early CAN; (2) at least two abnormal cardiovagal test results are required for definite or confirmed CAN; and (3) the presence of orthostatic hypotension in addition to abnormal heart rate test results identifies severe or advanced CAN. Progressive stages of CAN are associated with increasingly worse prognosis. CAN assessment is relevant in clinical practice for (1) diagnosis of CAN clinical forms, (2) detection and tailored treatment of CAN clinical correlates (e.g. tachycardia, orthostatic hypotension, non‐dipping, QT interval prolongation), (3) risk stratification for diabetic complications and cardiovascular morbidity and mortality, and (4) modulation of targets of diabetes therapy. Evidence on the cost‐effectiveness of CAN testing is lacking. Apart from the preventive role of intensive glycaemic control in type 1 diabetes, recommendations cannot be made for most therapeutic approaches to CAN. Copyright © 2011 John Wiley & Sons, Ltd.
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“Timely detection of CAN may help implementation of tailored interventions to prevent its progression and mitigate the risk of associated complications, including CVD, cardiac arrhythmias, myocardial dysfunction leading to congestive heart failure (CHF), CKD, and all-cause mortality.547,614,617–625”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [622]
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“Autonomic neuropathy can increase the risk of exercise-induced injury or adverse events through decreased cardiac responsiveness to exercise, postural hypotension, impaired thermoregulation, impaired night vision due to impaired papillary reaction, and greater susceptibility to hypoglycemia (277).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:Standards of Care in Diabetes—2023 (2023) · cites this paper as [277]
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Cites
Effects of Intensive Glucose Lowering in Type 2 Diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802743 · Cited by 7,888
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655
Intensive versus Conventional Glucose Control in Critically Ill Patients
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119
Glucose control and vascular complications in veterans with type 2 diabetes
Duckworth, W., Abraira, C., Moritz, T., Reda, D., Emanuele, N., Reaven, P. D., Zieve, F. J., Marks, J., Davis, S. N., Hayward, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808431 · Cited by 4,762
Effect of a multifactorial intervention on mortality in type 2 diabetes
Gæde, P., Lund-Andersen, H., Parving, H.-H., & Pedersen, O. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706245 · Cited by 3,465 · cited 1×
“with microalbuminuria [56].”
Tesfaye, S., Boulton, A. J. M., Dyck, P. J., Freeman, R., Horowitz, M., Kempler, P., Lauria, G., Malik, R. A., Spallone, V., Vinik, A., et al. (2010) · Diabetes Care · doi:10.2337/dc10-1303 · Cited by 2,690
Self-citationVinik, A. I., Maser, R. E., Mitchell, B. D., & Freeman, R. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1553 · Cited by 2,044
Self-citationBoulton, A. J. M., Vinik, A. I., Arezzo, J. C., Bril, V., Feldman, E. L., Freeman, R., Malik, R. A., Maser, R. E., Sosenko, J. M., & Ziegler, D. (2005) · Diabetes Care · doi:10.2337/diacare.28.4.956 · Cited by 1,859
Self-citationGuidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary
Rydén, L., Standl, E., Bartnik, M., den Berghe, G. V., Betteridge, J. D., de Boer, M., Cosentino, F., Jönsson, B., Laakso, M., Malmberg, K., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl260 · Cited by 1,644
The Value of Cardiovascular Autonomic Function Tests: 10 Years Experience in Diabetes
Ewing, D. J., Martyn, C., Young, R. J., & Clarke, B. F. (1985) · Diabetes Care · doi:10.2337/diacare.8.5.491 · Cited by 1,436
Diabetic cardiovascular autonomic neuropathy
Vinik, A. I., & Ziegler, D. (2007) · Circulation · doi:10.1161/circulationaha.106.634949 · Cited by 1,255
Self-citationThe Consensus Committee of the American Autonomic Society and the American Academy of Neurology (1996) · Neurology · doi:10.1212/wnl.46.5.1470 · Cited by 1,247
Primary Prevention of Cardiovascular Diseases in People With Diabetes Mellitus
Buse, J. B., Ginsberg, H. N., Bakris, G. L., Clark, N. G., Costa, F., Eckel, R., Fonseca, V., Gerstein, H. C., Grundy, S., Nesto, R. W., et al. (2007) · Diabetes Care · doi:10.2337/dc07-9917 · Cited by 1,055
Young, L. H., Wackers, F. J. T., Chyun, D. A., Davey, J. A., Barrett, E. J., Taillefer, R., Heller, G. V., Iskandrian, A. E., Wittlin, S. D., Filipchuk, N., et al. (2009) · JAMA · doi:10.1001/jama.2009.476 · Cited by 809
Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects
Wackers, F. J. T., Young, L. H., Inzucchi, S. E., Chyun, D. A., Davey, J. A., Barrett, E. J., Taillefer, R., Wittlin, S. D., Heller, G. V., Filipchuk, N., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.1954 · Cited by 791
Maser, R. E., Mitchell, B. D., Vinik, A. I., & Freeman, R. L. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1895 · Cited by 678
Self-citation19. Department of Internal Medicine
Katô/Chang (1999) · University of California Press eBooks · doi:10.1525/9780520923393-021 · Cited by 647
Primary Prevention of Cardiovascular Diseases in People With Diabetes Mellitus
Buse, J. B., Ginsberg, H. N., Bakris, G. L., Clark, N. G., Costa, F., Eckel, R. H., Fonseca, V. A., Gerstein, H. C., Grundy, S. M., Nesto, R. W., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.179294 · Cited by 634
Pop-Busui, R., Evans, G. W., Gerstein, H. C., Fonseca, V., Fleg, J. L., Hoogwerf, B. J., Genuth, S., Grimm, R. H., Corson, M. A., Prineas, R., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0125 · Cited by 540
Self-citationHypoglycemia, Diabetes, and Cardiovascular Events
Desouza, C. V., Bolli, G. B., & Fonseca, V. A. (2010) · Diabetes Care · doi:10.2337/dc09-2082 · Cited by 445
Neurogenic Orthostatic Hypotension
Freeman, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmcp074189 · Cited by 384
Self-citation2007 ESH‐ESC Guidelines for the management of arterial hypertension
Mansia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Blood Pressure · doi:10.1080/08037050701461084 · Cited by 361
EFNS guidelines on the diagnosis and management of orthostatic hypotension
Lahrmann, H., Cortelli, P., Hilz, M., Mathias, C. J., Struhal, W., & Tassinari, M. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01512.x · Cited by 334 · cited 3×
“Other possible treatments include (1) desmopressin acetate, a vasopressin analogue useful to correct nocturnal polyuria and morning orthostatic hypotension; (2) somatostatin analogues aimed at inhibiting the release of vasoactive gastrointestinal peptides, enhancing cardiac output, and increasing forearm and splanchni…”
BackgroundEngland, J. D., Gronseth, G., Franklin, G. M., Carter, G. T., Kinsella, L. J., Cohen, J. A., Asbury, A. K., Szigeti, K., Lupski, J. R., Latov, N., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000336345.70511.0f · Cited by 327
Self-citationAutonomic Symptoms and Diabetic Neuropathy
Low, P. A., Benrud‐Larson, L. M., Sletten, D. M., Opfer‐Gehrking, T. L., Weigand, S. D., O’Brien, P. C., Suárez, G. A., & Dyck, P. J. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2942 · Cited by 325
Self-citationPop-Busui, R., Low, P. A., Waberski, B. H., Martin, C. L., Albers, J. W., Feldman, E. L., Sommer, C., Cleary, P. A., Lachin, J. M., & Herman, W. H. (2009) · Circulation · doi:10.1161/circulationaha.108.837369 · Cited by 310
Self-citationNot Available, N. A. (1998) · Diabetologia · doi:10.1007/s001250050924 · Cited by 308
Report and Recommendations of the San Antonio Conference on Diabetic Neuropathy
American Diabetes Association, & American Academy of Neurology (1988) · Diabetes Care · doi:10.2337/diacare.11.7.592 · Cited by 286
Ziegler, D., Schatz, H., Conrad, F., Gries, F. A., Ulrich, H., The DEKAN Study Group, & Reichel, G. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.369 · Cited by 280
Self-citationPrevalence of orthostatic hypotension
Low, P. A. (2008) · Clinical Autonomic Research · doi:10.1007/s10286-007-1001-3 · Cited by 271
Self-citationValensi, P. E., Pariès, J., & Attali, J. R. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00095-7 · Cited by 247
Self-citationRecommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy☆
Spallone, V., Bellavere, F., Scionti, L., Maule, S. V., Quadri, R., Bax, G., Melga, P., Viviani, G. L., Esposito, K., & Morganti, R. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.07.005 · Cited by 243
Self-citationRelationship Between Risk Factors and Mortality in Type 1 Diabetic Patients in Europe
Soedamah‐Muthu, S. S., Chaturvedi, N., Witte, D. R., Stevens, L. K., Porta, M., Fuller, J., & for the EURODIAB Prospective Complications Study Group (2008) · Diabetes Care · doi:10.2337/dc08-0107 · Cited by 243
Valensi, P. E., Sachs, R.-N., Harfouche, B., Lormeau, B., Pariès, J., Cosson, E., Paycha, F., Leuténegger, M., & Attali, J. R. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.339 · Cited by 236
Self-citationCarnethon, M. R., Prineas, R. J., Temprosa, M., Zhang, Z.-M., Uwaifo, G., Molitch, M. E., & for the Diabetes Prevention Program Research Group (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1729 · Cited by 220
Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function
Adler, G. K., Bonyhay, I., Failing, H., Waring, E., Dotson, S., & Freeman, R. (2009) · Diabetes · doi:10.2337/db08-1153 · Cited by 216
Self-citationZiegler, D., Zentai, C. P., Perz, S., Rathmann, W., Haastert, B., Döring, A., Meisinger, C., & for the KORA Study Group (2008) · Diabetes Care · doi:10.2337/dc07-1615 · Cited by 210
Self-citationPalatini, P., Bénétos, A., Grassi, G. M., Julius, S., Kjeldsen, S. E., Mancia, G., Narkiewicz, K., Parati, G., Pessina, A. C., Ruilope, L. M., et al. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000217838.49842.1e · Cited by 199
England, J. D., Gronseth, G., Franklin, G. M., Carter, G. T., Kinsella, L. J., Cohen, J. A., Asbury, A. K., Szigeti, K., Lupski, J. R., Latov, N., et al. (2009) · PM&R · doi:10.1016/j.pmrj.2008.11.011 · Cited by 192
Self-citationRisk factors for cardiac autonomic neuropathy in type 1 diabetes mellitus
Witte, D. R., Tesfaye, S. H., Chaturvedi, N., Eaton, S. E. M., Kempler, P., Fuller, J., & EURODIAB Prospective Complications Study Group (2004) · Diabetologia · doi:10.1007/s00125-004-1617-y · Cited by 189
Self-citationAstrup, A. S., Tarnow, L., Rossing, P. R., Hansen, B. V., Hilsted, J., & Parving, H. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1242 · Cited by 178
Self-citationHeart Rate Variability Predicts ESRD and CKD-Related Hospitalization
Brotman, D. J., Bash, L. D., Qayyum, R., Crews, D. C., Whitsel, E. A., Astor, B. C., & Coresh, J. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009111112 · Cited by 164
Assessment of brain SPECT [RETIRED]
(1996) · Neurology · doi:10.1212/wnl.46.1.278 · Cited by 150
QT interval, cardiovascular risk factors and risk of death in diabetes
Veglio, M., Chinaglia, A., & Cavallo‐Perin, P. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03346265 · Cited by 145
The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence
Nordin, C. (2010) · Diabetologia · doi:10.1007/s00125-010-1752-6 · Cited by 143
Spallone, V., Gambardella, S., Maiello, M. R., Barini, A., Frontoni, S., & Menzinger, G. (1994) · Diabetes Care · doi:10.2337/diacare.17.6.578 · Cited by 142
Self-citationSpallone, V., Bernardi, L., Ricordi, L., Pl, S., Maiello, M. R., Calciati, A., Gambardella, S., Fratino, P., & Menzinger, G. (1993) · Diabetes · doi:10.2337/diabetes.42.12.1745 · Cited by 134
Self-citationPathophysiology in Diabetic Autonomic Neuropathy: Cardiovascular, Hormonal, and Metabolic Studies
Hilsted, J. (1982) · Diabetes · doi:10.2337/diab.31.8.730 · Cited by 122
Self-citationType 2 diabetes mellitus and the risk of sudden cardiac arrest in the community
Siscovick, D. S., Sotoodehnia, N., Rea, T. D., Raghunathan, T. E., Jouven, X., & Lemaître, R. N. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9133-5 · Cited by 106
Whitsel, E. A., Boyko, E. J., & Siscovick, D. S. (2000) · Diabetes Care · doi:10.2337/diacare.23.2.241 · Cited by 104
Prospective study of autonomic neuropathy as a predictor of mortality in patients with diabetes
Wheeler, S., Ahroni, J. H., & Boyko, E. J. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(02)00128-6 · Cited by 88
Prince, C. T., Secrest, A. M., Mackey, R. H., Arena, V. C., Kingsley, L., & Orchard, T. J. (2009) · Diabetes Care · doi:10.2337/dc09-1936 · Cited by 88
Valensi, P. E., Johnson, N., Maison‐Blanche, P., Extramania, F., Motté, G., & Coumel, P. (2002) · Diabetes Care · doi:10.2337/diacare.25.5.918 · Cited by 75
Self-citationThe consensus statement on the definition of orthostatic hypotension: a revisit after 13 years
Wieling, W., & Schatz, I. J. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832b1145 · Cited by 73
An Overview of the Effect of Weight Loss on Cardiovascular Autonomic Function
Maser, R. E., & Lenhard, M. J. (2007) · Current Diabetes Reviews · doi:10.2174/157339907781368931 · Cited by 73
Lykke, J. A., Tarnow, L., Parving, H. ‐., & Hilsted, J. (2008) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510802018330 · Cited by 66
Self-citationKadoi, Y. (2010) · Journal of Anesthesia · doi:10.1007/s00540-010-0987-1 · Cited by 54
Dinh, W., Füth, R., Lankisch, M., Bansemir, L., Nickl, W., Scheffold, T., Bufe, A., Krahn, T., & Ziegler, D. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03221.x · Cited by 53
Self-citationProgression of Cardiovascular Autonomic Dysfunction in Patients With Type 2 Diabetes
Ko, S., Park, S.-A., Cho, J., Song, K., Yoon, K., Cha, B., Son, H., Yoo, K., Moon, K., Park, Y., et al. (2008) · Diabetes Care · doi:10.2337/dc08-0682 · Cited by 46
QTc and autonomic neuropathy in diabetes: Effects of acute hyperglycaemia and n-3 PUFA
Santini, V., Ciampittiello, G., Gigli, F., Bracaglia, D., Baroni, A., Cicconetti, E., Verri, C., Gambardella, S., & Frontoni, S. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.09.006 · Cited by 37
Self-citationSpallone, V., Maiello, M. R., Morganti, R., Mandica, S., & Frajese, G. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002162 · Cited by 34
Self-citationIt is not yet the time to stop screening diabetic patients for silent myocardial ischaemia
Valensi, P. E., & Cosson, E. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.01.001 · Cited by 34
Self-citationKempler, P., Tesfaye, S. H., Chaturvedi, N., Stevens, L. K., Webb, D. J., Eaton, S., Kerényi, Z., Tamás, G., Ward, J. D., & Fuller, J. (2001) · Archives of Physiology and Biochemistry · doi:10.1076/apab.109.3.215.11589 · Cited by 32
Self-citationPharmacologic modulation of autonomic tone: implications for the diabetic patient
Aronson, D. (1997) · Diabetologia · doi:10.1007/s001250050704 · Cited by 29
Flagged first, then by citations
2 of the 67 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Ziegler D, 1993, Prevalence and clinical correlates of cardiovascular autonomic and peripheral diabetic neuropathy in patients attending diabetes centers, Diabetes Metab, 19, 143
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Metadata
- Authors
- Spallone, V., Ziegler, D., Freeman, R., Bernardi, L., Frontoni, S., Pop‐Busui, R., Stevens, M., Kempler, P., Hilsted, J., Tesfaye, S., Low, P., Valensi, P., & Neuropathy, O. B. O. T. T. C. P. O. D.
- Affiliations
- University of Rome Tor Vergata (IT)
- Düsseldorf University Hospital (DE)
- Beth Israel Deaconess Medical Center (US)
- University of Pavia (IT)
- University of Michigan (US)
- University of Birmingham (GB)
- Copenhagen University Hospital (DK)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Mayo Clinic (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Corresponding author
- Spallone, Vincenza
- ORCID
- Venue
- Diabetes/Metabolism Research and Reviews
- Publisher
- Wiley
- Published
- 2011-10
- Volume
- 27
- Issue
- 7
- Pages
- 639-653
- ISSN
- 1520-7552 (ISSN-L)
- 1520-7560
- OpenAlex
- W2086516175
- Cited by
- 957
- References
- 67
- Citations by year
- 2026: 65 · 2025: 67 · 2024: 78 · 2023: 63 · 2022: 71 · 2021: 86 · 2020: 93 · 2019: 62 · 2018: 78 · 2017: 54 · 2016: 61 · 2015: 60 · 2014: 52 · 2013: 34 · 2012: 24
- FWCI
- 37.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes/Metabolism Research and Reviews (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- cardiac autonomic neuropathy, diabetes mellitus, orthostatic hypotension, glycemic control, cardiovascular morbidity and mortality, diabetic nephropathy progression, risk stratification, type 1 diabetes, type 2 diabetes
- MeSH terms
- Autonomic Nervous System, Blood Glucose, Cardiovascular Diseases, Diabetic Neuropathies, Humans, Prognosis, Disease Management
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