The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Gene regulatory factors in pancreatic development
Open accessAbstract
The intensity of research on pancreatic development has increased markedly in the past 5 years, primarily for two reasons: we now know that the insulin‐producing β‐cells normally arise from an endodermally derived, pancreas‐specified precursor cell, and successful transplants of islet cells have been performed, relieving patients with type I diabetes of symptoms for extended periods after transplantation. Combining in vitro β‐cell formation from a pancreatic biopsy of a diabetic patient or from other stem‐cell sources followed by endocrine cell transplantation may be the most beneficial route for a future diabetes therapy. However, to achieve this, a thorough understanding of the genetic components regulating the development of β‐cells is required. The following review discusses our current understanding of the transcription factor networks necessary for pancreatic development and how several genetic interactions coming into play at the earliest stages of endodermal development gradually help to build the pancreatic organ. Developmental Dynamics 229:176–200, 2004. © 2003 Wiley‐Liss, Inc.
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Hayhurst, G. P., Lee, Y.-H., Lambert, G., Ward, J. M., & Gonzalez, F. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1393-1403.2001 · Cited by 1,107
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
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The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
Kawaguchi, Y., Cooper, B., Gannon, M., Ray, M., MacDonald, R. J., & Wright, C. V. E. (2002) · Nature Genetics · doi:10.1038/ng959 · Cited by 1,007 · cited 8×
“As this phenotype reflects that of the Ptf1a mutant mice (Kawaguchi et al., 2002), it raises the possibility that HlxB9 is capable of negatively regulating Ptf1a expression in the pancreatic domains.”
BackgroundResultInfluentialDepletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Ang, S.-L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J., & Zaret, K. S. (1993) · Development · doi:10.1242/dev.119.4.1301 · Cited by 618 · cited 2×
“A key gene in endodermal development in most species is the forkhead gene Foxa2 or its orthologues like axial (Ang et al., 1993; Ang and Rossant, 1994).”
BackgroundRegulation of pancreas development by hedgehog signaling
Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.22.4905 · Cited by 412
Notochord to endoderm signaling is required for pancreas development
Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development · doi:10.1242/dev.124.21.4243 · Cited by 405
Activin receptor patterning of foregut organogenesis
Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A. (2000) · Genes & Development · doi:10.1101/gad.14.15.1866 · Cited by 212 · cited 2×
“, 1998) display a strongly hypoplastic islet mass at late embryogenesis as do compound heterozygous mice of the Activin type IIA and B receptors (Kim et al., 2000).”
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Cited by
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
D'Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O. G., Agulnick, A. D., Smart, N. G., Moorman, M. A., Kroon, E., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,915
Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
Xu, X., D'Hoker, J., Stangé, G., Bonné, S., De Leu, N., Xiao, X., Van De Casteele, M., Mellitzer, G., Ling, Z., Pipeleers, D., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.015 · Cited by 988
CellRank for directed single-cell fate mapping
Lange, M., Bergen, V., Klein, M., Setty, M., Reuter, B., Bakhti, M., Lickert, H., Ansari, M., Schniering, J., Schiller, H. B., et al. (2022) · Nature Methods · doi:10.1038/s41592-021-01346-6 · Cited by 768
Metadata
- Authors
- Jensen, J.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2003-12-10
- Volume
- 229
- Issue
- 1
- Pages
- 176-200
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2025397278
- Cited by
- 372
- References
- 8
- FWCI
- 20.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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