E‐ and P‐cadherin expression during murine hair follicle morphogenesis and cycling
Abstract
The role of adhesion molecules in the control of hair follicle (HF) morphogenesis, regression and cycling is still rather enigmatic. Since the adhesion molecules E- and P-cadherin (Ecad and Pcad) are functionally important, e.g. during embryonic pattern formation, we have studied their expression patterns during neonatal HF morphogenesis and cycling in C57/BL6 mice by immunohistology and semi-quantitative RT-PCR. The expression of both cadherins was strikingly hair cycle-dependent and restricted to distinct anatomical HF compartments. During HF morphogenesis, hair bud keratinocytes displayed strong Ecad and Pcad immunoreactivity (IR). While neonatal epidermis showed Ecad IR in all epidermal layers, Pcad IR was restricted to the basal layer. During later stages of HF morphogenesis and during anagen IV-VI of the adolescent murine hair cycle, the outer root sheath showed strong E- and Pcad IR. Instead, the outermost portion of the hair matrix and the inner root sheath displayed isolated Ecad IR, while the innermost portion of the hair matrix exhibited isolated Pcad IR. During telogen, all epidermal and follicular keratinocytes showed strong Ecad IR. This is in contrast to Pcad, whose IR was stringently restricted to matrix and secondary hair germ keratinocytes which are in closest proximity to the dermal papilla. These findings suggest that isolated or combined E- and/or Pcad expression is involved in follicular pattern formation by segregating HF keratinocytes into functionally…
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The spindle-culture method enabled hair follicle formation in the presence of melanocytes and pigmentation.
“The spindle-culture method not only enabled hair follicle formation in the presence of melanocytes and pigmentation [45,46] but also significantly promoted the efficiency of hair follicle formation up to 80% efficiency when compared to other culture conditions (Figure 5B–F).”
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- Authors
- Müller‐Röver, S., Tokura, Y., Welker, P., Furukawa, F., Wakita, H., Takigawa, M., & Paus, R.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Hamamatsu University (JP)
- Corresponding author
- Paus, R.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 1999-08
- Volume
- 8
- Issue
- 4
- Pages
- 237-246
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2010098391
- Cited by
- 86
- References
- 57
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- E-cadherin, P-cadherin, hair follicle morphogenesis, hair cycle, adhesion molecules, outer root sheath, dermal papilla, telogen, anagen, hair growth disorders
- MeSH terms
- Aging, Animals, Animals, Newborn, Female, Immunohistochemistry, Mice, Inbred C57BL, Cadherins, Hair Follicle, Reverse Transcriptase Polymerase Chain Reaction, Mice
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