The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Pluripotent neural crest stem cells in the adult hair follicle
Open accessAbstract
We report the presence of pluripotent neural crest stem cells in the adult mammalian hair follicle. Numerous neural crest cells reside in the outer root sheath from the bulge to the matrix at the base of the follicle. Bulge explants from adult mouse whisker follicles yield migratory neural crest cells, which in clonal culture form colonies consisting of over a thousand cells. Clones contain neurons, smooth muscle cells, rare Schwann cells and melanocytes, demonstrating pluripotency of the clone‐forming cell. Targeted differentiation into Schwann cells and chondrocytes was achieved with neuregulin‐1 and bone morphogenetic protein‐2, respectively. Serial cloning in vitro demonstrated self‐renewal capability. Together, the data show that the adult mouse whisker follicle contains pluripotent neural crest stem cells, termed epidermal neural crest cells (eNCSC). eNCSC are promising candidates for diverse cell therapy paradigms because of their high degree of inherent plasticity and due to their easy accessibility in the skin. Developmental Dynamics 231:258–269, 2004. © 2004 Wiley‐Liss, Inc.
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Cites
Tissue origins and interactions in the mammalian skull vault.
Jiang, X., Iseki, S., Maxson, R. E., Sucov, H. M., & Morriss-Kay, G. M. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0487 · Cited by 782
Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489
Cited by
A tumorigenic subpopulation with stem cell properties in melanomas
Fang, D., Nguyen, T. K., Leishear, K., Finko, R., Kulp, A. N., Hotz, S., Van Belle, P. A., Xu, X., Elder, D. E., & Herlyn, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1343 · Cited by 1,280
Exploring the role of stem cells in cutaneous wound healing
Lau, K., Paus, R., Tiede, S., Day, P., & Bayat, A. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00942.x · Cited by 279
Stripes and belly-spots—A review of pigment cell morphogenesis in vertebrates
Kelsh, R. N., Harris, M. L., Colanesi, S., & Erickson, C. A. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.10.001 · Cited by 202
Budi, E. H., Patterson, L. B., & Parichy, D. M. (2008) · Development · doi:10.1242/dev.019299 · Cited by 136
Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility
Lang, M. R., Patterson, L. B., Gordon, T. N., Johnson, S. L., & Parichy, D. M. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000744 · Cited by 86
Metadata
- Authors
- Sieber‐Blum, M., Grim, M., Hu, Y. F., & Szeder, V.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2004-07-28
- Volume
- 231
- Issue
- 2
- Pages
- 258-269
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W2087211932
- Cited by
- 387
- References
- 2
- FWCI
- 16.35
- Type
- journal article
- Language
- en
- Open access
- green
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