The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Interactions between SOX factors and Wnt/β‐catenin signaling in development and disease
Open accessAbstract
The SOX family of transcription factors have emerged as modulators of canonical Wnt/β‐catenin signaling in diverse development and disease contexts. There are over 20 SOX proteins encoded in the vertebrate genome and recent evidence suggests that many of these can physically interact with β‐catenin and modulate the transcription of Wnt‐target genes. The precise mechanisms by which SOX proteins regulate β‐catenin/TCF activity are still being resolved and there is evidence to support a number of models including: protein–protein interactions, the binding of SOX factors to Wnt‐target gene promoters, the recruitment of co‐repressors or co‐activators, modulation of protein stability, and nuclear translocation. In some contexts, Wnt signaling also regulates SOX expression resulting in feedback regulatory loops that fine‐tune cellular responses to β‐catenin/TCF activity. In this review, we summarize the examples of Sox–Wnt interactions and examine the underlying mechanisms of this potentially widespread and underappreciated mode of Wnt‐regulation. Developmental Dynamics 239:56–68, 2010. © 2009 Wiley‐Liss, Inc.
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Wnt/β-Catenin Signaling in Development and Disease
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β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
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Sox9 is required for cartilage formation
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Cited by
TCF/LEFs and Wnt Signaling in the Nucleus
Cadigan, K. M., & Waterman, M. L. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007906 · Cited by 760
Metadata
- Authors
- Kormish, J. D., Sinner, D., & Zorn, A. M.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2009-08-04
- Volume
- 239
- Issue
- 1
- Pages
- 56-68
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- OpenAlex
- W1963807629
- Cited by
- 266
- References
- 104
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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