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Regenerative response following stab injury in the adult zebrafish telencephalon

Open access
März, Martin, Schmidt, Rebecca, Rastegar, Sepand, Strähle, Uwe·2011·Developmental Dynamics

Abstract

In contrast to mammals, the brain of the adult zebrafish has a remarkable ability to regenerate. In mammals, injuries induce proliferation of astrocytes and oligodendrocyte progenitors contributing to the formation of a glial scar. We analyzed the proliferation of glial cells and microglia in response to stab injury in the adult zebrafish telencephalon: Radial glial markers were up‐regulated at the ventricle and co‐expressed the proliferation nuclear antigen (PCNA). Microglia and oligodendrocyte progenitors accumulated transiently at the site of lesion. However, we could not find evidence of permanent scar formation. Parenchymal proliferation was almost negligible in comparison to the increase in proliferation at the ventricular zone. This suggests that most of the cellular material for regeneration is derived from regions of constitutive neurogenesis. Remarkably, the proliferative response is almost completely restricted to the lesioned hemisphere indicating that signals inducing regeneration remain mainly confined within the lesioned half of the telencephalon. Developmental Dynamics 240:2221–2231, 2011. © 2011 Wiley‐Liss, Inc.

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Metadata

Authors
März, M., Schmidt, R., Rastegar, S., & Strähle, U.
Venue
Developmental Dynamics
Publisher
Wiley
Published
2011-08-16
Volume
240
Issue
9
Pages
2221-2231
ISSN
  • 1058-8388 (ISSN-L)
  • 1097-0177
OpenAlex
W2085320324
Cited by
187
References
11
FWCI
2.74
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Regenerative response following stab injury in the adult zebrafish telencephalon. https://app.cochat.ai/papers/10.1002/dvdy.22710
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März, M., Schmidt, R., Rastegar, S., & Strähle, U. (2011). Regenerative response following stab injury in the adult zebrafish telencephalon. Developmental Dynamics. https://doi.org/10.1002/dvdy.22710

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