The DOI matches its Crossref record; 307 of the 307 references it cites were found in a registry or an index.
Glial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain
Abstract
The diverse functions of glial cells prompt the question to which extent specific subtypes may be devoted to a specific function. We discuss this by reviewing one of the most recently discovered roles of glial cells, their function as neural stem cells (NSCs) and progenitor cells. First we give an overview of glial stem and progenitor cells during development; these are the radial glial cells that act as NSCs and other glial progenitors, highlighting the distinction between the lineage of cells in vivo and their potential when exposed to a different environment, e.g., in vitro. We then proceed to the adult stage and discuss the glial cells that continue to act as NSCs across vertebrates and others that are more lineage-restricted, such as the adult NG2-glia, the most frequent progenitor type in the adult mammalian brain, that remain within the oligodendrocyte lineage. Upon certain injury conditions, a distinct subset of quiescent astrocytes reactivates proliferation and a larger potential, clearly demonstrating the concept of heterogeneity with distinct subtypes of, e.g., astrocytes or NG2-glia performing rather different roles after brain injury. These new insights not only highlight the importance of glial cells for brain repair but also their great potential in various aspects of regeneration.
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Cites
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Cited by
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Marques, S., Zeisel, A., Codeluppi, S., van Bruggen, D., Mendanha Falcão, A., Xiao, L., Li, H., Häring, M., Hochgerner, H., Romanov, R. A., et al. (2016) · Science · doi:10.1126/science.aaf6463 · Cited by 1,132
Glia as architects of central nervous system formation and function
Allen, N. J., & Lyons, D. A. (2018) · Science · doi:10.1126/science.aat0473 · Cited by 1,001
Brain Cell Type Specific Gene Expression and Co-expression Network Architectures
McKenzie, A. T., Wang, M., Hauberg, M. E., Fullard, J. F., Kozlenkov, A., Keenan, A., Hurd, Y. L., Dracheva, S., Casaccia, P., Roussos, P., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-27293-5 · Cited by 481
Elusive roles for reactive astrocytes in neurodegenerative diseases
Ben Haim, L., Carrillo-de Sauvage, M.-A., Ceyzériat, K., & Escartin, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00278 · Cited by 453
Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex
Heinrich, C., Bergami, M., Gascón, S., Lepier, A., Viganò, F., Dimou, L., Sutor, B., Berninger, B., & Götz, M. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.10.007 · Cited by 323
Self-citation
Metadata
- Authors
- Dimou, L., & Götz, M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2014-07
- Volume
- 94
- Issue
- 3
- Pages
- 709-737
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2117122511
- Cited by
- 264
- References
- 307
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
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