Endogenous progenitors remyelinate demyelinated axons in the adult CNS

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

Bignami, A., Eng, L. F., Dahl, D. R., & Uyeda, C. T. (1972) · Brain Research · doi:10.1016/0006-8993(72)90398-8 · Cited by 1,456 · see citing works

Use of a recombinant retrovirus to study post‐implantation cell lineage in mouse embryos.

Sanes, J. R., Rubenstein, J. L. R., & Nicolas, J. F. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04620.x · Cited by 1,116 · see citing works

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

Deibler, G. E., Martenson, R. E., & Kies, M. W. (1972) · Preparative Biochemistry · doi:10.1080/00327487208061467 · Cited by 939 · see citing works

Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.

Price, J., Turner, D., & Cepko, C. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.156 · Cited by 878 · see citing works

Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions

Prineas, J. W., Barnard, R. O., Kwon, E. E., Sharer, L. R., & Cho, E. ‐. (1993) · Annals of Neurology · doi:10.1002/ana.410330203 · Cited by 574 · see citing works

Proliferation and differentiation of rat neuroepithelial precursor cells in vivo

Frederiksen, K., & McKay, R. D. G. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01144.1988 · Cited by 551 · see citing works

Identification of an adult-specific glial progenitor cell

Wolswijk, G., & Noble, M. A. (1989) · Development · doi:10.1242/dev.105.2.387 · Cited by 485 · see citing works

Proliferating bipotential glial progenitor cells in adult rat optic nerve

ffrench‐Constant, C., & RAFF, M. C. (1986) · Nature · doi:10.1038/319499a0 · Cited by 385 · see citing works

Multiple Sclerosis: Remyelination in Acute Lesions

Raine, C. S., & WU, E. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199305000-00003 · Cited by 285 · see citing works

The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord

Hall, S. (1972) · Journal of Cell Science · doi:10.1242/jcs.10.2.535 · Cited by 275 · see citing works

Pre-oligodendrocytes from adult human CNS

Armstrong, R., Dorn, H. H., Kufta, C. V., Friedman, E., & Dubois-Dalcq, M. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-04-01538.1992 · Cited by 270 · see citing works

Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions.

Prineas, J. W., Kwon, E. E., Goldenberg, P. Z., Ilyas, A. A., Quarles, R. H., Benjamins, J. A., & Sprinkle, T. J. (1989) · PubMed · Cited by 265 · see citing works

Multiple sclerosis. Oligodendrocyte survival and proliferation in an active established lesion.

Raine, C. S., Scheinberg, L. C., & Waltz, J. M. (1981) · PubMed · Cited by 264 · see citing works

Restoration of Normal Conduction Properties in Demyelinated Spinal Cord Axons in the Adult Rat by Transplantation of Exogenous Schwann Cells

Honmou, O., Felts, P. A., Waxman, S. G., & Kocsis, J. D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03199.1996 · Cited by 249 · see citing works

In situ demonstration of mature oligodendrocytes and their processes: An immunocytochemical study with a new monoclonal antibody, Rip

Friedman, B., Hockfield, S. J., Black, J. A., Woodruff, K., & Waxman, S. G. (1989) · Glia · doi:10.1002/glia.440020510 · Cited by 248 · see citing works

The in vivo and ultrastructural effects of injection of lysophosphatidyl choline into myelinated peripheral nerve fibres of the adult mouse

Hall, S., & Gregson, N. A. (1971) · Journal of Cell Science · doi:10.1242/jcs.9.3.769 · Cited by 196 · see citing works

Proliferation of mature oligodendrocytes after trauma to the central nervous system

Ludwin, S. K. (1984) · Nature · doi:10.1038/308274a0 · Cited by 178 · see citing works

The origin of remyelinating cells in the adult central nervous system: The role of the mature oligodendrocyte

Wood, P. M., & Bunge, R. P. (1991) · Glia · doi:10.1002/glia.440040214 · Cited by 139 · see citing works

Mitotic division of neuroglia in the normal adult rat

Hommes, O. R., & Leblond, C. P. (1967) · The Journal of Comparative Neurology · doi:10.1002/cne.901290304 · Cited by 135 · see citing works

An autoradiographic study of cellular proliferation in remyelination of the central nervous system.

Ludwin, S. K. (1979) · PubMed Central · Cited by 118 · see citing works

Functional Capacities of Transplanted Cell-Sorted Adult Oligodendrocytes

Duncan, I. D., Paı́no, C. L., Archer, D. R., & Wood, P. M. (1992) · Developmental Neuroscience · doi:10.1159/000111655 · Cited by 110 · see citing works

Correlation of glial proliferation with age in the mouse brain

Dalton, M. M., Hommes, O. R., & Leblond, C. P. (1968) · The Journal of Comparative Neurology · doi:10.1002/cne.901340403 · Cited by 99 · see citing works

Can oligodendrocytes attached to myelin proliferate?

Ludwin, S. K., & Bakker, D. A. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01239.1988 · Cited by 82 · see citing works

Retroviruses and the study of cell lineage

Price, J. (1987) · Development · doi:10.1242/dev.101.3.409 · Cited by 77 · see citing works

Multiple sclerosis. Interactions between oligodendrocytes and hypertrophic astrocytes and their occurrence in other, nondemyelinating conditions.

Wu, E., & Raine, C. S. (1992) · PubMed · Cited by 76 · see citing works

In vivo characterization of endogenous proliferating cells in adult rat subcortical white matter

Gensert, J. M., & Goldman, J. E. (1996) · Glia · doi:10.1002/(sici)1098-1136(199605)17:1 · Cited by 75 · see citing works

Induction of NF-kB-like transcription factors in brain areas susceptible to kainate toxicity

P�rez-Ota�o, I., McMillian, M., Chen, J. L., Bing, G., Hong, J. S., & Pennypacker, K. R. (1996) · Glia · doi:10.1002/(sici)1098-1136(199604)16:4 · Cited by 72 · see citing works

Transplantation of oligodendrocyte precursors in the adult demyelinated spinal cord: Migration and remyelination

Vignais, L., Nait‐Oumesmar, B., Mellouk, F. Z., Gout, O., Labourdette, G., Evercooren, A. B., & Gumpel, M. (1993) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(93)90049-j · Cited by 64 · see citing works

The O-2Aadult progenitor cell: a glial stem cell of the adult central nervous system

Noble, M., Wren, D. R., & Wolswijk, G. (1992) · Seminars in Cell Biology · doi:10.1016/1043-4682(92)90012-k · Cited by 56 · see citing works

Cultured epithelioid astrocytes migrate after transplantation into the adult rat brain

Emmett, C. J., Lawrence, J. M., Raisman, G., & Seeley, P. J. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903110304 · Cited by 44 · see citing works

Remyelination in demyelinating diseases of the central nervous system.

Ludwin, S. K. (1987) · PubMed · Cited by 41 · see citing works

Transplantation of cultured type 1 astrocyte cell suspensions into young, adult and aged rat cortex: Cell migration and survival

Andersson, C., Tytell, M., & Brunso‐Bechtold, J. K. (1993) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(93)90045-f · Cited by 38 · see citing works

Central nervous system remyelination: Studies in chronically damaged tissue

Ludwin, S. K. (1994) · Annals of Neurology · doi:10.1002/ana.410360735 · Cited by 29 · see citing works

Amphoterin (P30, HMG-1) and RIP are early markers of oligodendrocytes in the developing rat spinal cord

Daston, M. M., & Ratner, N. (1994) · Journal of Neurocytology · doi:10.1007/bf01188500 · Cited by 26 · see citing works

Myelination by mature ovine oligodendrocytes in vivo and in vitro: Evidence that different steps in the myelination process are independently controlled

Ludwin, S. K., & Szuchet, S. (1993) · Glia · doi:10.1002/glia.440080402 · Cited by 26 · see citing works

Future prospects for the management of multiple sclerosis

Compston, A. (1994) · Annals of Neurology · doi:10.1002/ana.410360736 · Cited by 17 · see citing works

Glial cell transplantation and the repair of demyelinating lesions

Blakemore, W. F., Franklin, R. J. M., & Noble, M. (1997) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9781872748542.003.0011 · Cited by 12 · see citing works

Transplantation of Myelinating Cells into the Central Nervous System

Duncan, I. D., & Archer, D. R. (1994) · Springer eBooks · doi:10.1007/978-1-4615-2435-9_20 · Cited by 5 · see citing works

Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System

Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828 · see citing works

The glial scar and central nervous system repair

Fawcett, J. W., & Asher, R. A. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00072-6 · Cited by 1,808 · see citing works

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,788 · see citing works

Remyelination in the CNS: from biology to therapy

Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544 · see citing works

Neural Tissue Engineering: Strategies for Repair and Regeneration

Schmidt, C. E., & Leach, J. B. (2003) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.5.011303.120731 · Cited by 1,236 · see citing works

The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats

Bareyre, F. M., Kerschensteiner, M., Raineteau, O., Mettenleiter, T. C., Weinmann, O., & Schwab, M. E. (2004) · Nature Neuroscience · doi:10.1038/nn1195 · Cited by 1,088 · see citing works

Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

Pluchino, S., Quattrini, A., Brambilla, E., Gritti, A., Salani, G., Dina, G., Galli, R., Carro, U. D., Amadio, S., Bergami, A., et al. (2003) · Nature · doi:10.1038/nature01552 · Cited by 1,071 · see citing works

TNFα promotes proliferation of oligodendrocyte progenitors and remyelination

Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012 · see citing works

Origin of oligodendrocytes in the subventricular zone of the adult brain

Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972 · see citing works

PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961 · see citing works

Oligodendrocytes: biology and pathology

Bradl, M., & Lassmann, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0601-5 · Cited by 933 · see citing works

Why does remyelination fail in multiple sclerosis?

Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 837 · see citing works

Regenerating the damaged central nervous system

Horner, P. J., & Gage, F. H. (2000) · Nature · doi:10.1038/35039559 · Cited by 831 · see citing works

Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

Nishiyama, A., Komitova, M., Suzuki, R., & Zhu, X. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2495 · Cited by 865 · see citing works

Plasticity of motor systems after incomplete spinal cord injury

Raineteau, O., & Schwab, M. E. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067570 · Cited by 804 · see citing works

The oligodendrocyte precursor cell in health and disease

Levine, J. M., Reynolds, R., & Fawcett, J. W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01691-x · Cited by 673 · see citing works

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination

Zawadzka, M., Rivers, L. E., Fancy, S. P. J., Zhao, C., Tripathi, R., Jamen, F., Young, K., Goncharevich, A., Pohl, H., Rizzi, M., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.04.002 · Cited by 650 · see citing works

Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

Hofstetter, C. P., Holmström, N., Lilja, J., Schweinhardt, P., Hao, J., Spenger, C., Wiesenfeld‐Hallin, Z., Kurpad, S. N., Frisén, J., & Olson, L. (2005) · Nature Neuroscience · doi:10.1038/nn1405 · Cited by 641 · see citing works

The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625 · see citing works

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

Zhang, Z. G., & Chopp, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70061-4 · Cited by 596 · see citing works

Neurotrophin-3 and Brain-Derived Neurotrophic Factor Induce Oligodendrocyte Proliferation and Myelination of Regenerating Axons in the Contused Adult Rat Spinal Cord

McTigue, D. M., Horner, P. J., Stokes, B. T., & Gage, F. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05354.1998 · Cited by 592 · see citing works

Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells

Wolswijk, G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00601.1998 · Cited by 498 · see citing works

Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination

Nait‐Oumesmar, B., Decker, L., Lachapelle, F., Avellana‐Adalid, V., Bachelin, C., & Van Evercooren, A. B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00873.x · Cited by 560 · see citing works

Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex

Dimou, L., Simon, C., Kirchhoff, F., Takebayashi, H., & Götz, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2831-08.2008 · Cited by 551 · see citing works

A regenerative approach to the treatment of multiple sclerosis

Deshmukh, V. A., Tardif, V., Lyssiotis, C. A., Green, C. C., Kerman, B., Kim, H. J., Padmanabhan, K., Swoboda, J. G., Ahmad, I., Kondo, T., et al. (2013) · Nature · doi:10.1038/nature12647 · Cited by 522 · see citing works

Interleukin-1β Promotes Repair of the CNS

Mason, J. L., Suzuki, K., Chaplin, D. D., & Matsushima, G. K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07046.2001 · Cited by 502 · see citing works

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

Shen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 486 · see citing works

Axonal pathology in multiple sclerosis: relationship to neurologic disability

Trapp, B. D., Ransohoff, R. M., & Rudick, R. A. (1999) · Current Opinion in Neurology · doi:10.1097/00019052-199906000-00008 · Cited by 475 · see citing works

The life, death, and replacement of oligodendrocytes in the adult CNS

McTigue, D. M., & Tripathi, R. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05570.x · Cited by 455 · see citing works

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D. (2004) · Science · doi:10.1126/science.1103709 · Cited by 416 · see citing works

Protein synthesis‐dependent but Bcl‐2‐independent cytochrome C release in zinc depletion‐induced neuronal apoptosis

Ahn, Y.-H., Koh, J., & Hong, S. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000901)61:5 · Cited by 21 · see citing works

Spinal cord injury is accompanied by chronic progressive demyelination

Totoiu, M. O., & Keirstead, H. S. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20517 · Cited by 372 · see citing works

Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter

Káradóttir, R. T., Hamilton, N. B., Bakiri, Y., & Attwell, D. (2008) · Nature Neuroscience · doi:10.1038/nn2060 · Cited by 370 · see citing works

A functional role for EGFR signaling in myelination and remyelination

Aguirre, A. A., Dupree, J. L., Mangin, J., & Gallo, V. (2007) · Nature Neuroscience · doi:10.1038/nn1938 · Cited by 352 · see citing works

The link between excitotoxic oligodendroglial death and demyelinating diseases

Matute, C., Alberdi, E. M., Domercq, M., Pérez‐Cerdá, F., Pérez‐Samartín, A., & Sánchez‐Gómez, M. V. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01746-x · Cited by 346 · see citing works

Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination

Woodruff, R. H., Fruttiger, M., Richardson, W. D., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.10.014 · Cited by 335 · see citing works

Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression

Kotter, M. R., Zhao, C., van Rooijen, N., & Franklin, R. J. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.019 · Cited by 331 · see citing works

Astrocytes in multiple sclerosis: A product of their environment

Nair, A., Frederick, T., & Miller, S. D. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8059-5 · Cited by 312 · see citing works

Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS

Fancy, S. P. J., Zhao, C., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.06.015 · Cited by 302 · see citing works

Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis

Scolding, N. J. (1998) · Brain · doi:10.1093/brain/121.12.2221 · Cited by 293 · see citing works

Glial Progenitors in Adult White Matter Are Driven to Form Malignant Gliomas by Platelet-Derived Growth Factor-Expressing Retroviruses

Assanah, M., Lochhead, R. A., Ogden, A. T., Bruce, J., Goldman, J. E., & Canoll, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0514-06.2006 · Cited by 289 · see citing works

Activation and Proliferation of Endogenous Oligodendrocyte Precursor Cells during Ethidium Bromide-Induced Demyelination

Levine, J. M., & Reynolds, R. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7224 · Cited by 282 · see citing works

Functional Recovery in Traumatic Spinal Cord Injury after Transplantation of Multineurotrophin-Expressing Glial-Restricted Precursor Cells

Cao, Q., Xu, X., DeVries, W. H., Enzmann, G. U., Ping, P., Tsoulfas, P., Wood, P. M., Bunge, M. B., & Whittemore, S. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1065-05.2005 · Cited by 281 · see citing works

NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease

Tripathi, R. B., Rivers, L. E., Young, K. M., Jamen, F., & Richardson, W. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3411-10.2010 · Cited by 277 · see citing works

Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis

Ben‐Hur, T., Einstein, O., Mizrachi‐Kol, R., Menachem-Zidon, O. B., Reinhartz, E., Karussis, D. M., & Abramsky, O. (2002) · Glia · doi:10.1002/glia.10159 · Cited by 272 · see citing works

Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord

Wolswijk, G. (2002) · Brain · doi:10.1093/brain/awf031 · Cited by 268 · see citing works

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

Miron, V. E., Ludwin, S. K., Darlington, P. J., Jarjour, A. A., Soliven, B. C., Kennedy, T. E., & Antel, J. P. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091234 · Cited by 267 · see citing works

Glial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain

Dimou, L., & Götz, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2013 · Cited by 263 · see citing works

Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion

Watanabe, M., Toyama, Y., & Nishiyama, A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10338 · Cited by 261 · see citing works

NG 2‐glia and their functions in the central nervous system

Dimou, L., & Gallo, V. (2015) · Glia · doi:10.1002/glia.22859 · Cited by 258 · see citing works

The adult oligodendrocyte can participate in remyelination

Duncan, I. D., Radcliff, A. B., Heidari, M., Kidd, G., August, B. K., & Wierenga, L. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808064115 · Cited by 259 · see citing works

Identification, Isolation, and Promoter-Defined Separation of Mitotic Oligodendrocyte Progenitor Cells from the Adult Human Subcortical White Matter

Roy, N. S., Wang, S., Harrison‐Restelli, C., Benraiss, A., Fraser, R. A. R., Gravel, M., Braun, P. E., & Goldman, S. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09986.1999 · Cited by 259 · see citing works

FTY720 modulates human oligodendrocyte progenitor process extension and survival

Miron, V. E., Jung, C., Kim, H. J., Kennedy, T. E., Soliven, B. C., & Antel, J. P. (2007) · Annals of Neurology · doi:10.1002/ana.21227 · Cited by 255 · see citing works

Stem cell repair of central nervous system injury

Cao, Q., Benton, R. L., & Whittemore, S. R. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10240 · Cited by 254 · see citing works

Cells of the oligodendroglial lineage, myelination, and remyelination

Miron, V. E., Kuhlmann, T., & Antel, J. P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.09.010 · Cited by 236 · see citing works

A novel family of ancient vertebrate odorant receptors

Berghard, A., & Dryer, L. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19981115)37:3 · Cited by 50 · see citing works

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

Cai, W., Yang, T., Liu, H., Han, L., Zhang, K., Hu, X., Zhang, X., Yin, K., Gao, Y., Bennett, M. V. L., et al. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.002 · Cited by 238 · see citing works

Insulin-Like Growth Factor-1 Inhibits Mature Oligodendrocyte Apoptosis during Primary Demyelination

Mason, J. L., Ye, P., Suzuki, K., D'Ercole, A. J., & Matsushima, G. K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05703.2000 · Cited by 237 · see citing works

Cell migration in the normal and pathological postnatal mammalian brain

Cayre, M., Canoll, P., & Goldman, J. E. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.02.001 · Cited by 235 · see citing works

White Matter Plasticity and Enhanced Remyelination in the Maternal CNS

Gregg, C., Shikar, V., Larsen, P. H., Mak, G. K., Chojnacki, A. K., Yong, V. W., & Weiss, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4441-06.2007 · Cited by 231 · see citing works

Myelin damage and repair in pathologic CNS: challenges and prospects

Alizadeh, A., Dyck, S. M., & Karimi‐Abdolrezaee, S. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00035 · Cited by 230 · see citing works

NG2‐expressing cells as oligodendrocyte progenitors in the normal and demyelinated adult central nervous system

Polito, A., & Reynolds, R. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00454.x · Cited by 231 · see citing works

Disease-associated oligodendrocyte responses across neurodegenerative diseases

Pandey, S., Shen, K., Lee, S.-H., Shen, Y.-A. A., Wang, Y., Otero-García, M., Kotova, N., Vito, S. T., Laufer, B. I., Newton, D. F., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111189 · Cited by 227 · see citing works

Marrow stromal cell transplantation in stroke and traumatic brain injury

Li, Y., & Chopp, M. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.096 · Cited by 222 · see citing works

Distinctive Patterns of PDGF-A, FGF-2, IGF-I, and TGF-β1 Gene Expression during Remyelination of Experimentally-Induced Spinal Cord Demyelination

Hinks, G. L., & Franklin, R. J. M. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0771 · Cited by 220 · see citing works

Purification and Characterization of Adult Oligodendrocyte Precursor Cells from the Rat Optic Nerve

Shi, J., Marinovich, A. M., & Barres, B. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04627.1998 · Cited by 219 · see citing works

Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity

Zhang, S., Ge, B., & Duncan, I. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4089 · Cited by 217 · see citing works

Oligodendrocytes and Progenitors Become Progressively Depleted within Chronically Demyelinated Lesions

Mason, J. L., Toews, A., Hostettler, J. D., Morell, P., Suzuki, K., Goldman, J. E., & Matsushima, G. K. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63726-1 · Cited by 212 · see citing works

Identity, distribution, and development of polydendrocytes: NG2-expressing glial cells

Nishiyama, A., Watanabe, M., Yang, Z., & Bu, J. (2002) · Journal of Neurocytology · doi:10.1023/a:1025783412651 · Cited by 211 · see citing works

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling

Baer, A. S., Syed, Y. A., Kang, S. U., Mitteregger, D., Vig, R., ffrench-Constant, C., Franklin, R. J. M., Altmann, F., Lubec, G., & Kotter, M. R. (2009) · Brain · doi:10.1093/brain/awn334 · Cited by 211 · see citing works

Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination

Zhang, Y., Argaw, A. T., Gurfein, B. T., Zameer, A., Snyder, B. J., Ge, C., Lu, Q. R., Rowitch, D. H., Raine, C. S., Brosnan, C. F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902834106 · Cited by 210 · see citing works

Experimental strategies to promote spinal cord regeneration—an integrative perspective

Schwab, J. M., Brechtel, K., Mueller, C.-A., Failli, V., Kaps, H.-P., Tuli, S. K., & Schluesener, H. J. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.12.004 · Cited by 208 · see citing works

Expression of nitric oxide synthase-2 (NOS-2) in reactive astrocytes of the human glaucomatous optic nerve head

Liu, B., & Neufeld, A. H. (2000) · Glia · doi:10.1002/(sici)1098-1136(200004)30:2 · Cited by 177 · see citing works

Transplantation of Ciliary Neurotrophic Factor-Expressing Adult Oligodendrocyte Precursor Cells Promotes Remyelination and Functional Recovery after SpinalCord Injury

Cao, Q., He, Q., Wang, Y., Cheng, X., Howard, R. M., Zhang, Y., DeVries, W. H., Shields, C. B., Magnuson, D. S. K., Xu, X., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3174-09.2010 · Cited by 203 · see citing works

Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain

Tabar, V. S., Panagiotakos, G., Greenberg, E. D., Chan, B. K., Sadelain, M., Gutin, P. H., & Studer, L. (2005) · Nature Biotechnology · doi:10.1038/nbt1088 · Cited by 197 · see citing works

Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation

Sugawa, M., Sakurai, Y., Ishikawa-Ieda, Y., Suzuki, H., & Asou, H. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00161-x · Cited by 197 · see citing works

Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes

Talbott, J. F., Loy, D. N., Liu, Y., Qiu, M. S., Bunge, M. B., Rao, M. S., & Whittemore, S. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.038 · Cited by 195 · see citing works

Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury

Seo, J. H., Miyamoto, N., Hayakawa, K., Pham, L. D., Maki, T., Ayata, C., Kim, K., Lo, E. H., & Arai, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65863 · Cited by 195 · see citing works

The role of propriospinal interneurons in recovery from spinal cord injury

Flynn, J. R., Graham, B. A., Galea, M. P., & Callister, R. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.016 · Cited by 192 · see citing works

Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division

Hill, R., Patel, K. D., Gonçalves, C. M., Grutzendler, J., & Nishiyama, A. (2014) · Nature Neuroscience · doi:10.1038/nn.3815 · Cited by 186 · see citing works

Regenerative response following stab injury in the adult zebrafish telencephalon

März, M., Viales, R. R., Rastegar, S., & Strähle, U. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22710 · Cited by 187 · see citing works

Long-Term Impact of Radiation on the Stem Cell and Oligodendrocyte Precursors in the Brain

Panagiotakos, G., Al-Shamy, G., Chan, B., Abrams, R. M. C., Greenberg, E. D., Saxena, A., Bradbury, M. S., Edgar, M. A., Gutin, P. H., & Tabar, V. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000588 · Cited by 184 · see citing works

Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum

Etxeberría, A., Mangin, J., Aguirre, A. A., & Gallo, V. (2010) · Nature Neuroscience · doi:10.1038/nn.2500 · Cited by 181 · see citing works

Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis

Stephenson, D. T., O'Neill, S. M., Narayan, S., Tiwari, A., Arnold, E., Samaroo, H. D., Du, F., Ring, R. H., Campbell, B., Pletcher, M., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-7 · Cited by 180 · see citing works

NG2 proteoglycan‐expressing cells of the adult rat brain: Possible involvement in the formation of glial scar astrocytes following stab wound

Alonso, G. (2004) · Glia · doi:10.1002/glia.20121 · Cited by 178 · see citing works

Generation of oligodendroglial progenitors in acute inflammatory demyelinating lesions of the rat brain stem is associated with demyelination rather than inflammation

di Bello, I. C., Dawson, M. R. L., Levine, J. M., & Reynolds, R. (1999) · Journal of Neurocytology · doi:10.1023/a:1007069815302 · Cited by 178 · see citing works

Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination

Mason, J. L., Xuan, S., Dragatsis, I., Efstratiadis, A., & Goldman, J. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07710.2003 · Cited by 177 · see citing works

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

Nissen, J. C., Thompson, K. K., West, B. L., & Tsirka, S. E. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.05.021 · Cited by 168 · see citing works

The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS

Reynolds, R., Dawson, M., Papadopoulos, D., Polito, A., di Bello, I. C., Pham-Dinh, D., & Levine, J. (2002) · Journal of Neurocytology · doi:10.1023/a:1025747832215 · Cited by 175 · see citing works

Selective retinal pigment epithelial cell lipid metabolism and remodeling conserves photoreceptor docosahexaenoic acid following phagocytosis

Turco, E., Parkins, N., Ershov, A. V., & Bazan, N. G. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990815)57:4 · Cited by 51 · see citing works

Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre

Mason, J. L., Langaman, C., Morell, P., Suzuki, K., & Matsushima, G. K. (2001) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2001.00301.x · Cited by 172 · see citing works

Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells

Setzu, A., Lathia, J. D., Zhao, C., Wells, K., Rao, M. S., ffrench‐Constant, C., & Franklin, R. J. M. (2006) · Glia · doi:10.1002/glia.20371 · Cited by 171 · see citing works

Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination

Samanta, J., Grund, E. M., Silva, H. M., Lafaille, J. J., Fishell, G., & Salzer, J. L. (2015) · Nature · doi:10.1038/nature14957 · Cited by 170 · see citing works

Neurorestorative Therapy for Stroke

Chen, J., Venkat, P., Zacharek, A., & Chopp, M. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00382 · Cited by 169 · see citing works

A role for CXCL12 (SDF-1α) in the pathogenesis of multiple sclerosis: Regulation of CXCL12 expression in astrocytes by soluble myelin basic protein

Calderon, T. M., Eugenín, E. A., Lopez, L., Kumar, S. S., Hesselgesser, J., Raine, C. S., & Berman, J. W. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.05.003 · Cited by 166 · see citing works

Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor

González-Pérez, Ó., & Álvarez-Buylla, A. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.01.001 · Cited by 171 · see citing works

Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain

Windrem, M. S., Roy, N. S., Wang, J., Nunes, M. C., Benraiss, A., Goodman, R., McKhann, G. M., & Goldman, S. A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10397 · Cited by 168 · see citing works

Exercise reverses ethanol inhibition of neural stem cell proliferation

Crews, F. T., Nixon, K., & Wilkie, M. E. (2004) · Alcohol · doi:10.1016/j.alcohol.2004.04.005 · Cited by 165 · see citing works

In VivoAnalysis of Ascl1 Defined Progenitors Reveals Distinct Developmental Dynamics during Adult Neurogenesis and Gliogenesis

Kim, E. J., Leung, C. T., Reed, R. R., & Johnson, J. E. B. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3178-07.2007 · Cited by 163 · see citing works

Spatial and temporal expression of S100B in cells of oligodendrocyte lineage

Hachem, S., Aguirre, A., Vives, V., Marks, A., Gallo, V., & Legraverend, C. (2005) · Glia · doi:10.1002/glia.20184 · Cited by 167 · see citing works

The adult oligodendrocyte can participate in remyelination

Duncan, I. D., Radcliff, A. B., Heidari, M., Kidd, G., August, B. K., & Wierenga, L. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808064115 · Cited by 259 · see citing works

The origin of remyelinating cells in the central nervous system

Blakemore, W. F., & Keirstead, H. S. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00083-1 · Cited by 147 · see citing works

Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination

Nait‐Oumesmar, B., Decker, L., Lachapelle, F., Avellana‐Adalid, V., Bachelin, C., & Van Evercooren, A. B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00873.x · Cited by 560 · see citing works

Do central nervous system axons remyelinate?

Nait‐Oumesmar, B., Lachapelle, F., Decker, L., & Evercooren, A. B. (2000) · PubMed · Cited by 13 · see citing works

Identification of A2B5-positive putative oligodendrocyte progenitor cells and A2B5-positive astrocytes in adult human white matter

Scolding, N. J., Rayner, P. J., & Compston, D. A. S. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00548-x · Cited by 92 · see citing works