Altered brain activity in women recovered from bulimic-type eating disorders after a glucose challenge: A pilot study
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OBJECTIVE: It is not known whether individuals with bulimic-type eating disorders have a dysregulation of brain pathways that modulate appetite. Taste plays a role in the regulation of appetite and the purpose of the current study was to determine whether bulimic women have alterations in the physiologic response to the blind administration of glucose. METHOD: To avoid the confounding effects of a current eating disorder, and to assess possibly trait-related disturbances, we studied 10 subjects recovered (> or = 1 year) from a bulimic-type eating disorder and 6 control women. Subjects were administered a solution of glucose or artificial saliva (control solution) in alternating blocks during a functional magnet resonance imaging scan. RESULTS: Individuals who recovered from a bulimic-type eating disorder had significantly lower activation in the right anterior cingulate cortex (ACC; Montreal Neurological Institute [MNI] coordinates x = 8, y = 22, z = 28; cluster size = 18 voxels, T = 5.11, Z-score = 3.78) and in the left cuneus (occipital cortex; MNI coordinates x = -12, y = -78, z = 10; cluster size = 21 voxels, T = 4.27, Z-score = 3.36), when glucose was compared with artificial saliva. CONCLUSION: The ACC plays a role in the anticipation of reward. Individuals with bulimic-type eating disorders may have a reduced reward response to nutrients, and thus may be vulnerable to overeating. However, this is a small sample and the current study will need replication in a larger sample size with investigation of additional regions of interest.
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Other studies have found atypical responses during reward outcome for monetary and food rewards in BN.
“Other studies have found atypical responses during reward outcome for monetary and food rewards.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [324]
Participants who recovered from bulimia show decreased ACC reward outcome responses to blinded administration of glucose.
“Frank and colleagues [324] reported decreased ACC reward outcome responses to the blinded administration of glucose in participants who had recovered from bulimia.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [324]
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- Authors
- Frank, G. K., Wagner, A., Achenbach, S., McConaha, C., Skovira, K., Aizenstein, H., Carter, C. S., & Kaye, W. H.
- Affiliations
- University of Pittsburgh (US)
- University of California, Davis (US)
- Corresponding author
- Kaye, Walter H.
- Venue
- International Journal of Eating Disorders
- Publisher
- Wiley
- Published
- 2006-01
- Volume
- 39
- Issue
- 1
- Pages
- 76-79
- ISSN
- 0276-3478 (ISSN-L)
- 1098-108X
- OpenAlex
- W2147045461
- Cited by
- 68
- References
- 31
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 8
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Eating Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- National Institute of Mental Health (K05 MH018940, MH-46001, R01 MH42984, T32-MH-18399, R01MH046001, R01MH042984, T32MH018399)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- eating disorder recovery, glucose challenge test, anterior cingulate cortex, cuneus, reward anticipation, appetite regulation, women
- MeSH terms
- Adult, Brain, Convalescence, Glucose, Humans, Magnetic Resonance Imaging, Pilot Projects, Body Mass Index, Bulimia Nervosa
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