Caspases Connect Cell-Death Signaling to Organismal Homeostasis

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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The Inflammasome

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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Immunogenic Cell Death in Cancer Therapy

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FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

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Type I interferons in infectious disease

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Apoptosis: controlled demolition at the cellular level

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Non-canonical inflammasome activation targets caspase-11

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Mechanisms and Functions of Inflammasomes

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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

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Inflammatory caspases are innate immune receptors for intracellular LPS

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Programmed Cell Death in Animal Development and Disease

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways

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Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

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Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

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Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

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Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

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Type I interferons in anticancer immunity

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Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

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Old, new and emerging functions of caspases

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Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

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Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

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Autophagy in malignant transformation and cancer progression

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Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis

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Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

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Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

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Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

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Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

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Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

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Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

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Mechanisms of pre‐apoptotic calreticulin exposure in immunogenic cell death

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Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

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Consensus guidelines for the detection of immunogenic cell death

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In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

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Mitochondria: master regulators of danger signalling

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IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

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Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

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Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

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TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

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Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

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Inflammasomes in carcinogenesis and anticancer immune responses

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Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

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Caspase-11 Protects Against Bacteria That Escape the Vacuole

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Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

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Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

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Apoptotic Cells Activate the “Phoenix Rising” Pathway to Promote Wound Healing and Tissue Regeneration

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Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

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Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

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Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

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Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells

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NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5

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Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

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Human caspase 12 has acquired deleterious mutations

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Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

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Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

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Caspase-14 protects against epidermal UVB photodamage and water loss

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A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant.

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Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

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Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

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Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

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Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

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Molecular mechanisms of regulated necrosis

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Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

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Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

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Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing

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Organelle-specific initiation of cell death

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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming

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Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

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Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

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