The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Prevalence and Prognostic Impact of the Coexistence of Multiple Frailty Domains in Elderly Patients with Heart Failure: The FRAGILE-HF Cohort Study
Open accessAbstract
Aims: To describe the prevalence, overlap, and prognostic implications of physical and social frailties and cognitive dysfunction in hospitalized elderly patients with heart failure. Methods and results: The FRAGILE-HF study was a prospective multicentre cohort study enrolling consecutive hospitalized patients with heart failure aged ≥65 years. The study objectives were to examine the prevalence, overlap, and prognostic implications of the coexistence of multiple frailty domains. Physical frailty, social frailty, and cognitive dysfunction were evaluated by the Fried phenotype model, Makizako’s 5 items, and Mini-Cog, respectively. The primary study outcome was the combined endpoint of heart failure rehospitalization and all-cause death within 1 year. Among 1180 enrolled hospitalized patients (median age, 81 years; 57.4% male), physical frailty, social frailty, and cognitive dysfunction were identified in 56.1%, 66.4%, and 37.1% of the patients, respectively. The number of identified frailty domains was 0, 1, 2, and 3 in 13.5%, 31.4%, 36.9%, and 18.2% of the patients, respectively. During follow-up, the combined endpoint occurred in 383 patients. Adjusted hazard ratios for 1, 2, and 3 domains, with 0 domains as the reference, were 1.38 [95% confidence interval (CI) 0.89–2.13; P = 0.15], 1.60 (95% CI 1.04–2.46; P = 0.034), and 2.04 (95% CI 1.28–3.24; P = 0.003), respectively. Incorporating the number of frailty domains into the pre-existing risk model yielded a 22.0% (95% CI 0.087–0.352; P = 0.001) net reclassification improvement for the primary outcome. Conclusions: The coexistence of multiple frailty domains is prevalent in hospitalized elderly patients with heart failure. Holistic assessment of multi-domain frailty provides additive value to known prognostic factors.
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Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
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Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
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Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
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The Global Health and Economic Burden of Hospitalizations for Heart Failure
Ambrosy, A. P., Fonarow, G. C., Butler, J., Chioncel, O., Greene, S. J., Vaduganathan, M., Nodari, S., Lam, C. S. P., Sato, N., Shah, A. N., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.053 · Cited by 2,046
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The Mini-Cog: a cognitive ?vital signs? measure for dementia screening in multi-lingual elderly
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The Mini-Cog as a screen for dementia: validation in a population-based sample
Borson, S., Scanlan, J. M., Chen, P., & Ganguli, M. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51465.x · Cited by 1,348
Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies
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Phenotype of frailty: characterization in the women's health and aging studies
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Cited by
Hirose, S., Matsue, Y., Kamiya, K., Kagiyama, N., Hiki, M., Dotare, T., Sunayama, T., Konishi, M., Saito, H., Saito, K., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.01.014 · Cited by 101
Self-citationSaito, H., Matsue, Y., Kamiya, K., Kagiyama, N., Maeda, D., Endo, Y., Ueno, H., Yoshioka, K., Mizukami, A., Saito, K., et al. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03168-3 · Cited by 78
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Metadata
- Authors
- Matsue, Y., Kamiya, K., Saito, H., Saito, K., Ogasahara, Y., Maekawa, E., Konishi, M., Kitai, T., Iwata, K., Jujo, K., Wada, H., Kasai, T., Nagamatsu, H., Ozawa, T., Izawa, K., Yamamoto, S., Aizawa, N., Yonezawa, R., Oka, K., Momomura, S.-I., & Kagiyama, N.
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-07-14
- Volume
- 22
- Issue
- 11
- Pages
- 2112-2119
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W3034004005
- Cited by
- 283
- References
- 39
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matsue, Y., Kamiya, K., Saito, H., Saito, K., Ogasahara, Y., Maekawa, E., Konishi, M., Kitai, T., Iwata, K., Jujo, K., Wada, H., Kasai, T., Nagamatsu, H., Ozawa, T., Izawa, K., Yamamoto, S., Aizawa, N., Yonezawa, R., Oka, K., . . . Kagiyama, N. (2020). Prevalence and Prognostic Impact of the Coexistence of Multiple Frailty Domains in Elderly Patients with Heart Failure: The FRAGILE-HF Cohort Study. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.1926
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