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Cited by 1,215Frailty in Older AdultsChronic Disease Management StrategiesPharmaceutical Practices and Patient Outcomes

Phenotype of frailty: characterization in the women's health and aging studies

Bandeen-Roche, K., Xue, Q.-L., Ferrucci, L., Walston, J., Guralnik, J. M., Chaves, P., Zeger, S. L., Fried, L. P.·2006·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/61.3.262
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Abstract

BACKGROUND: "Frailty" is an adverse, primarily gerontologic, health condition regarded as frequent with aging and having severe consequences. Although clinicians claim that the extremes of frailty can be easily recognized, a standardized definition of frailty has proved elusive until recently. This article evaluates the cross-validity, criterion validity, and internal validity in the Women's Health and Aging Studies (WHAS) of a discrete measure of frailty recently validated in the Cardiovascular Health Study (CHS). METHODS: The frailty measure developed in CHS was delineated in the WHAS data sets. Using latent class analysis, we evaluated whether criteria composing the measure aggregate into a syndrome. We verified the criterion validity of the measure by testing whether participants defined as frail were more likely than others to develop adverse geriatric outcomes or to die. RESULTS: The distributions of frailty in the WHAS and CHS were comparable. In latent class analyses, the measures demonstrated strong internal validity vis à vis stated theory characterizing frailty as a medical syndrome. In proportional hazards models, frail women had a higher risk of developing activities of daily living (ADL) and/or instrumental ADL disability, institutionalization, and death, independently of multiple potentially confounding factors. CONCLUSIONS: The findings of this study are consistent with the widely held theory that conceptualizes frailty as a syndrome. The frailty definition developed in the CHS is applicable across diverse population samples and identifies a profile of high risk of multiple adverse outcomes.

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Crossref · 10.1093/gerona/61.3.262

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  • A transition to a greater level of frailty is more common than improvement.

    “a transition to a level of greater frailty is more common than improvement”

    From Frailty in elderly people (2013) · cites this paper as [93]

  • Frailty is a dynamic process.

    “Frailty is a dynamic process (93)”

    From Frailty in elderly people (2013) · cites this paper as [93]

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Authors
Bandeen-Roche, K., Xue, Q.-L., Ferrucci, L., Walston, J., Guralnik, J. M., Chaves, P., Zeger, S. L., & Fried, L. P.
ORCID
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
2006-03-01
Volume
61
Issue
3
Pages
262-266
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/61.3.262
OpenAlex
W2152456824
Cited by
1,215
References
30
Citations by year
2026: 31 · 2025: 36 · 2024: 67 · 2023: 43 · 2022: 60 · 2021: 64 · 2020: 80 · 2019: 89 · 2018: 62 · 2017: 77 · 2016: 86 · 2015: 75 · 2014: 82 · 2013: 77 · 2012: 65
FWCI
18.81
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Johns Hopkins University
  • National Institutes of Health
  • National Institute on Aging (1R37AG199502, R01 AG11703, 1P50AG021334-01, R01AG011703)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
frailty, Fried frailty phenotype, Women's Health and Aging Study, Cardiovascular Health Study, cross-validation, criterion validity, internal validity, activities of daily living disability, institutionalization, mortality, older women, aging
MeSH terms
Aged, Aging, Female, Humans, Phenotype, Geriatric Assessment, Frail Elderly, Women's Health

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