The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Analysing Recurrent Hospitalizations in Heart Failure: A Review of Statistical Methodology, with Application to CHARM-Preserved
Open accessAbstract
Aims: Heart failure is characterized by recurrent hospitalizations, but often only the first event is considered in clinical trial reports. In chronic diseases, such as heart failure, analysing all events gives a more complete picture of treatment benefit. We describe methods of analysing repeat hospitalizations, and illustrate their value in one major trial. Methods and results: The Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM)-Preserved study compared candesartan with placebo in 3023 patients with heart failure and preserved systolic function. The heart failure hospitalization rates were 12.5 and 8.9 per 100 patient-years in the placebo and candesartan groups, respectively. The repeat hospitalizations were analysed using the Andersen–Gill, Poisson, and negative binomial methods. Death was incorporated into analyses by treating it as an additional event. The win ratio method and a method that jointly models hospitalizations and mortality were also considered. Using repeat events gave larger treatment benefits than time to first event analysis. The negative binomial method for the composite of recurrent heart failure hospitalizations and cardiovascular death gave a rate ratio of 0.75 [95% confidence interval (CI) 0.62–0.91, P = 0.003], whereas the hazard ratio for time to first heart failure hospitalization or cardiovascular death was 0.86 (95% CI 0.74–1.00, P = 0.050). Conclusions: In patients with preserved EF, candesartan reduces the rate of admissions for worsening heart failure, to a greater extent than apparent from analysing only first hospitalizations. Recurrent events should be routinely incorporated into the analysis of future clinical trials in heart failure.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As a pre-specified statistical method, we used the negative binomial regression model to calculate rates and rate ratios for total cardiovascular events, which accounts for the variability in each patient's risk of events (45-47).”
From Effects of Icosapent Ethyl on Total Ischemic Events (2019) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879
Self-citationCox’s regression model for counting processes: A large sample study
Andersen, P. K., & Gill, R. D. (1982) · The Annals of Statistics · doi:10.1214/aos/1176345976 · Cited by 4,419
Yusuf, S., Pfeffer, M. A., Swedberg, K., Granger, C. B., Held, P., McMurray, J. J., Michelson, E. L., Olofsson, B., & Östergren, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14285-7 · Cited by 2,994
Self-citationThe Robust Inference for the Cox Proportional Hazards Model
Lin, D. Y., & Wei, L. J. (1989) · Journal of the American Statistical Association · doi:10.1080/01621459.1989.10478874 · Cited by 2,695
ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs105 · Cited by 2,644
Self-citationMcMurray, J. J., Östergren, J., Swedberg, K., Granger, C. B., Held, P., Michelson, E. L., Olofsson, B., Yusuf, S., & Pfeffer, M. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14283-3 · Cited by 2,604
Self-citationPfeffer, M. A., Swedberg, K. B., Granger, C. B., Held, P., McMurray, J. J. V., Michelson, E. L., Olofsson, B., Östergren, J., & Yusuf, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14282-1 · Cited by 1,895
Self-citationGranger, C. B., McMurray, J. J., Yusuf, S., Held, P., Michelson, E. L., Olofsson, B., Östergren, J., Pfeffer, M. A., & Swedberg, K. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14284-5 · Cited by 1,686
Self-citationSolomon, S. D., Zile, M. R., Pieske, B. M., Voors, A. A., Shah, A. M., Kraigher‐Krainer, E., Shi, V. C., Bransford, T. L., Takeuchi, M., Gong, J., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61227-6 · Cited by 1,171
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
Self-citation2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab368 · Cited by 13,344
Self-citationCardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
Bhatt, D. L., Steg, P. G., Miller, M., Brinton, E. A., Jacobson, T. A., Ketchum, S. B., Doyle, R. T., Juliano, R. A., Jiao, L., Granowitz, C., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812792 · Cited by 3,317
Efficacy and safety of low-dose colchicine after myocardial infarction
Tardif, J.-C., Kouz, S., Waters, D. D., Bertrand, O. F., Diaz, R., Maggioni, A. P., Pinto, F. J., Ibrahim, R., Gamra, H., Kiwan, G. S., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1912388 · Cited by 3,159
2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Authors/Task Force Members:, McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2333 · Cited by 2,356
Self-citationPonikowski, P. P., Kirwan, B., Anker, S. D., McDonagh, T. A., Dorobanţu, M., Dróżdż, J., Fabien, V., Filippatos, G. S., Göhring, U., Keren, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32339-4 · Cited by 800
Self-citationEzekowitz, J. A., O'Meara, E., McDonald, M. A., Abrams, H., Chan, M., Ducharme, A., Giannetti, N., Grzeslo, A., Hamilton, P. G., Heckman, G. A., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.022 · Cited by 676
Heart failure with mid-range or mildly reduced ejection fraction
Savarese, G., Stolfo, D., Sinagra, G., & Lund, L. H. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00605-5 · Cited by 514
McMurray, J. J. V., DeMets, D. L., Inzucchi, S. E., Køber, L., Kosiborod, M. N., Langkilde, A. M., Martinez, F. A., Bengtsson, O., Ponikowski, P., Sabatine, M. S., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1432 · Cited by 433
Self-citationAnker, S. D., Kirwan, B., van Veldhuisen, D. J., Filippatos, G. S., Colet, J. C., Ruschitzka, F. T., Lüscher, T. F., Arutyunov, G. P., Motro, M., Mori, C., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.823 · Cited by 411
Self-citationCefalu, W. T., Kaul, S., Gerstein, H. C., Holman, R. R., Zinman, B., Skyler, J. S., Green, J. B., Buse, J. B., Inzucchi, S. E., Leiter, L. A., et al. (2017) · Diabetes Care · doi:10.2337/dci17-0057 · Cited by 387
Rossignol, P., Hernandez, A. F., Solomon, S. D., & Zannad, F. (2019) · The Lancet · doi:10.1016/s0140-6736(18)31808-7 · Cited by 316
Self-citationSolomon, S. D., de Boer, R. A., DeMets, D. L., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M., Lam, C. S. P., Martínez, F. A., Shah, S. J., Lindholm, D. P., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2249 · Cited by 345
Self-citationAngiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction
Solomon, S. D., Rizkala, A. R., Gong, J., Wang, W., Anand, I. S., Ge, J., Lam, C. S. P., Maggioni, A. P., Martínez, F. A., Packer, M., et al. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2017.04.013 · Cited by 317
Self-citationThe Primary Outcome Fails — What Next?
Pocock, S., & Stone, G. W. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1510064 · Cited by 275
Self-citationEffects of Icosapent Ethyl on Total Ischemic Events
Bhatt, D. L., Steg, P. G., Miller, M., Brinton, E. A., Jacobson, T. A., Ketchum, S. B., Doyle, R. T., Juliano, R. A., Jiao, L., Granowitz, C., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.02.032 · Cited by 259
Self-citationZannad, F., Garcia, A. A., Anker, S. D., Armstrong, P. W., Calvo, G., Cleland, J. G. F., Cohn, J. N., Dickstein, K., Domanski, M. J., Ekman, I., et al. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft095 · Cited by 231
Self-citationThe win ratio approach for composite endpoints: practical guidance based on previous experience
Redfors, B., Gregson, J., Crowley, A., McAndrew, T., Ben‐Yehuda, O., Stone, G. W., & Pocock, S. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa665 · Cited by 209
Self-citationRassi, A., Marin‐Neto, J. A., & Rassi, A. (2017) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760160334 · Cited by 182
Heart failure with preserved ejection fraction
HAMO, C. E., DeJong, C., Hartshorne‐Evans, N., Lund, L. H., Shah, S. J., Solomon, S. D., & Lam, C. S. P. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00540-y · Cited by 197
Self-citationCarbohydrate Antigen-125–Guided Therapy in Acute Heart Failure
Núñez, J. E., Llàcer, P., Bertomeu‐González, V., Bosch, M. J., Merlos, P., García‐Blas, S., Montagud, V., Bodı́, V., Bertoméu, V., Pedrosa, V., et al. (2016) · JACC Heart Failure · doi:10.1016/j.jchf.2016.06.007 · Cited by 151
Patient selection in heart failure with preserved ejection fraction clinical trials
Kelly, J. P., Mentz, R. J., Mebazaa, A., Voors, A. A., Butler, J., Roessig, L., Fiuzat, M., Zannad, F., Pitt, B., O’Connor, C. M., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.043 · Cited by 139
Effect of Rosuvastatin on Repeat Heart Failure Hospitalizations
Rogers, J. K., Jhund, P. S., Perez, A.-C., Böhm, M., Cleland, J. G., Gullestad, L., Kjekshus, J., van Veldhuisen, D. J., Wikstrand, J., Wedel, H., et al. (2014) · JACC: Heart Failure · doi:10.1016/j.jchf.2013.12.007 · Cited by 138
Self-citationMartin, N., Manoharan, K., Thomas, J., Davies, C., & Lumbers, R. T. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012721.pub2 · Cited by 131
Guía ESC 2021 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.11.027 · Cited by 147
Self-citationComparison of time-to-first event and recurrent-event methods in randomized clinical trials
Claggett, B., Pocock, S., Wei, L. J., Pfeffer, M. A., McMurray, J. J. V., & Solomon, S. D. (2018) · Circulation · doi:10.1161/circulationaha.117.033065 · Cited by 118
Self-citationKartsonaki, C. (2016) · Diagnostic histopathology · doi:10.1016/j.mpdhp.2016.06.005 · Cited by 107
Carson, P. E., Anand, I. S., Win, S., Rector, T. S., Haass, M., Lopez-Sendon, J. L., Miller, A. B., Teerlink, J. R., White, M., McKelvie, R. S., et al. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2014.12.017 · Cited by 103
Self-citationFudim, M., White, J., Pagidipati, N. J., Lokhnygina, Y., Wainstein, J., Murin, J., Iqbal, N., Öhman, P., Lopes, R. D., Reicher, B., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.041659 · Cited by 99
Anker, S. D., Schroeder, S., Atar, D., Bax, J. J., Ceconi, C., Cowie, M., Crisp, A., Dominjon, F., Ford, I., Ghofrani, H. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.516 · Cited by 108
Self-citationWin odds: An adaptation of the win ratio to include ties
Brunner, E., Vandemeulebroecke, M., & Mütze, T. (2021) · Statistics in Medicine · doi:10.1002/sim.8967 · Cited by 99
Atrial Fibrillation Exacerbates Cognitive Dysfunction and Cerebral Perfusion in Heart Failure
Alosco, M. L., Spitznagel, M. B., Sweet, L. H., Josephson, R., Hughes, J. W., & Gunstad, J. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12543 · Cited by 101
Platz, E., Jhund, P. S., Claggett, B. L., Pfeffer, M. A., Swedberg, K. B., Granger, C. B., Yusuf, S., Solomon, S. D., & McMurray, J. J. V. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.901 · Cited by 96
Self-citationDong, G., Qiu, J., Wang, D., & Vandemeulebroecke, M. (2017) · Journal of Biopharmaceutical Statistics · doi:10.1080/10543406.2017.1397007 · Cited by 95
Characterization of the Average Daily Ischemic and Bleeding Risk After Primary PCI for STEMI
Giustino, G., Mehran, R., Dangas, G., Kirtane, A. J., Redfors, B., Généreux, P., Brener, S. J., Prats, J., Pocock, S., Deliargyris, E., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.08.018 · Cited by 92
Self-citationRegistry-Based Pragmatic Trials in Heart Failure: Current Experience and Future Directions
Lund, L. H., Oldgren, J., & James, S. K. (2017) · Current Heart Failure Reports · doi:10.1007/s11897-017-0325-0 · Cited by 91
Heart failure preserved ejection fraction (HFpEF): an integrated and strategic review
Lekavich, C. L., Barksdale, D. J., Neelon, V. J., & Wu, J. R. (2015) · Heart Failure Reviews · doi:10.1007/s10741-015-9506-7 · Cited by 93
Mogensen, U. M., Gong, J., Jhund, P. S., Shen, L., Køber, L., Desai, A. S., Lefkowitz, M. P., Packer, M., Rouleau, J. L., Solomon, S. D., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1139 · Cited by 84
Self-citationKasiakogias, A., Rosei, E. A., Camafort, M., Ehret, G., Faconti, L., Ferreira, J. P., Brguljan-Hitij, J., Januszewicz, A., Kahan, T., Manolis, A. J., et al. (2021) · Journal of Hypertension · doi:10.1097/hjh.0000000000002910 · Cited by 81
Dong, G., Li, D., Ballerstedt, S., & Vandemeulebroecke, M. (2016) · Pharmaceutical Statistics · doi:10.1002/pst.1763 · Cited by 78
Jackson, N. C., Atar, D., Borentain, M., Breithardt, G., van Eickels, M., Endres, M., Fraass, U., Friede, T., Hannachi, H., Janmohamed, S. G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv213 · Cited by 79
Alosco, M. L., & Hayes, S. M. (2015) · Heart Failure Reviews · doi:10.1007/s10741-015-9488-5 · Cited by 77
The Win Ratio: On Interpretation and Handling of Ties
Dong, G., Hoaglin, D. C., Qiu, J., Matsouaka, R., Chang, Y., Wang, J., & Vandemeulebroecke, M. (2019) · Statistics in Biopharmaceutical Research · doi:10.1080/19466315.2019.1575279 · Cited by 80
for the Israel Heart Failure Disease Management Study (IHF-DMS) investigators, Kalter‐Leibovici, O., Freimark, D., Freedman, L. S., Kaufman, G., Ziv, A., Murad, H., Benderly, M., SILVERMAN, B. G., Friedman, N. L., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0855-z · Cited by 70
Santas, E., Valero, E., Mollar, A., García‐Blas, S., Palau, P., Miñana, G., Núñez, E., Sanchís, J. M., Chorro, F. J., & Núñez, J. E. (2016) · Revista Española de Cardiología · doi:10.1016/j.recesp.2016.06.027 · Cited by 69
Santas, E., Palau, P., Guazzi, M., de la Espriella, R., Miñana, G., Sanchís, J. M., Bayés‐Genís, A., Lupón, J., Chorro, F. J., & Núñez, J. E. (2019) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2019.05.024 · Cited by 69
Design of Major Randomized Trials
Pocock, S., Clayton, T. C., & Stone, G. W. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.10.036 · Cited by 71
Self-citationJhund, P. S., Ponikowski, P. P., Docherty, K. F., Gasparyan, S. B., Böhm, M., Chiang, C., Desai, A. S., Howlett, J. G., Kitakaze, M., Petrie, M. C., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.053659 · Cited by 71
Self-citationRogers, J. K., Yaroshinsky, A., Pocock, S., Stokar, D., & Pogoda, J. M. (2016) · Statistics in Medicine · doi:10.1002/sim.6853 · Cited by 62
Self-citationMartin, N., Manoharan, K., Davies, C., & Lumbers, R. T. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012721.pub3 · Cited by 67
Rosselló, X., & González‐Del‐Hoyo, M. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.06.027 · Cited by 64
2026 ESC Guidelines for the management of heart failure
Køber, L., Adamo, M., Ruwald, A., Tomasoni, D., Anderson, L., Andersson, C., Brugts, J. J., Chioncel, O. D., Donal, E., Ferdinandy, P., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag100 · Cited by 109
Fallacies of Using the Win Ratio in Cardiovascular Trials
Ajufo, E. C., Nayak, A., & Mehra, M. R. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.05.004 · Cited by 56
Santas, E., Valero, E., Mollar, A., García‐Blas, S., Palau, P., Miñana, G., Núñez, E., Sanchís, J. M., Chorro, F. J., & Núñez, J. E. (2016) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2016.06.021 · Cited by 54
Recurrent Events in Cardiovascular Trials
Gregson, J., Stone, G. W., Bhatt, D. L., Packer, M., Anker, S. D., Zeller, C., Redfors, B., & Pocock, S. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.07.024 · Cited by 55
Self-citationEhteshami‐Afshar, S., Mooney, L., Dewan, P., Desai, A. S., Lang, N. N., Lefkowitz, M. P., Petrie, M. C., Rizkala, A. R., Rouleau, J. L., Solomon, S. D., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019238 · Cited by 52
Self-citationPonikowski, P. P., van Veldhuisen, D. J., Colet, J. C., Ertl, G., Michel Komajda, N., VIu, M., McDonagh, T. A., Parkhomenko, A. N., Tavazzi, L., Levesque, V., et al. (2014) · ESC Heart Failure · doi:10.1002/ehf2.12006 · Cited by 52
Packer, M. (2016) · Circulation · doi:10.1161/circulationaha.116.023538 · Cited by 53
Patel, R., Sharma, A., Prasad, A., & Bansal, S. (2023) · Kidney Medicine · doi:10.1016/j.xkme.2023.100705 · Cited by 57
Rørth, R., Jhund, P. S., Mogensen, U. M., Kristensen, S. L., Petrie, M. C., Køber, L., & McMurray, J. J. V. (2018) · Diabetes Care · doi:10.2337/dc17-2583 · Cited by 50
Self-citationThe Future of Clinical Trials in Cardiovascular Medicine
Solomon, S. D., & Pfeffer, M. A. (2016) · Circulation · doi:10.1161/circulationaha.115.020723 · Cited by 41
Self-citationSurvival analyses in cardiovascular research, part II: statistical methods in challenging situations
Rosselló, X., & González‐Del‐Hoyo, M. (2021) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2021.07.001 · Cited by 46
Dewan, P., Solomon, S. D., Jhund, P. S., Inzucchi, S. E., Køber, L., Kosiborod, M. N., Martinez, F. A., Ponikowski, P., DeMets, D. L., Sabatine, M. S., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1867 · Cited by 41
Self-citationMyserlis, E. P., Malli, A., Kalaitzoglou, D., Kalaitzidis, G., Miligkos, M., Kokkinidis, D. G., & Kalogeropoulos, A. P. (2016) · Heart Failure Reviews · doi:10.1007/s10741-016-9587-y · Cited by 41
Glycine prevents pressure overload induced cardiac hypertrophy mediated by glycine receptor
Lü, Y., Zhu, X., Li, J., Fang, R., Wang, Z., Zhang, J., Li, K., Li, X., Bai, H., Yang, Q., et al. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.11.008 · Cited by 40
From ACE Inhibitors/ARBs to ARNIs in Coronary Artery Disease and Heart Failure (Part 2/5)
Leong, D. P., McMurray, J. J. V., Joseph, P. G., & Yusuf, S. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.068 · Cited by 40
Self-citationThe Current and Future Landscape of SERCA Gene Therapy for Heart Failure: A Clinical Perspective
Hayward, C., Banner, N. R., Morley-Smith, A. C., Lyon, A. R., & Harding, S. E. (2015) · Human Gene Therapy · doi:10.1089/hum.2015.018 · Cited by 36
Statistical methods for composite endpoints
Hara, H., Klaveren, D. V., Kogame, N., Chichareon, P., Modolo, R., Tomaniak, M., Ono, M., Kawashima, H., Takahashi, K., Capodanno, D., et al. (2021) · EuroIntervention · doi:10.4244/eij-d-19-00953 · Cited by 36
van Veldhuisen, D. J., Rienstra, M., Mosterd, A., Alings, M., van Asselt, A. D. I., Bouvy, M. L., Tijssen, J. G. P., Schaap, J., van der Wall, E. E., Voors, A. A., et al. (2024) · European Journal of Heart Failure · doi:10.1002/ejhf.3428 · Cited by 35
Spitzer, E., Hahn, R. T., Pîbarot, P., de Vries, T., Bax, J. J., Leon, M. B., & Mieghem, N. M. V. (2019) · Cardiac failure review · doi:10.15420/cfr.2018.41.2 · Cited by 35
Generalized pairwise comparison methods to analyze (non)prioritized composite endpoints
Verbeeck, J., Spitzer, E., de Vries, T., ES, G. A. V., Anderson, W. N., Mieghem, N. M. V., Leon, M. B., Molenberghs, G., & Tijssen, J. G. P. (2019) · Statistics in Medicine · doi:10.1002/sim.8388 · Cited by 35
Lund, L. H., James, S. K., DeVore, A. D., Anstrom, K. J., Fudim, M., Aaronson, K. D., Dahlström, U., Desvigne-Nickens, P. M., Fleg, J. L., Yang, S., et al. (2024) · European Journal of Heart Failure · doi:10.1002/ejhf.3453 · Cited by 36
Núñez, J. E., Rabinovich, G. A., Sandino, J., Mainar, L., Palau, P., Santas, E., Villanueva, M. P., Núñez, E., Bodı́, V., Chorro, F. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122360 · Cited by 34
Castiglione, V., Gentile, F., Ghionzoli, N., Chiriacò, M., Panichella, G., Aimo, A., Vergaro, G., Giannoni, A., Passino, C., & Emdin, M. (2023) · Cardiac failure review · doi:10.15420/cfr.2022.23 · Cited by 35
Generalized Pairwise Comparisons to Assess Treatment Effects
Verbeeck, J., Backer, M. D., Verwerft, J., Salvaggio, S., Valgimigli, M., Vranckx, P., Buyse, M. E., & Brunner, E. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.06.047 · Cited by 33
Docherty, K. F., Bayés‐Genís, A., Butler, J., Coats, A. J. S., Drazner, M. H., Joyce, E., & Lam, C. S. P. (2022) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suac113 · Cited by 40
Mao, L., Kim, K., & Li, Y. (2022) · Statistical Methods in Medical Research · doi:10.1177/09622802221084134 · Cited by 33
Learning from recent trials and shaping the future of acute heart failure trials
Mentz, R. J., Felker, G. M., Ahmad, T., Peacock, W. F., Pitt, B., Fiuzat, M., Maggioni, A. P., Gheorghiade, M., Ando, Y., Pocock, S., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.08.001 · Cited by 32
Self-citationProcalcitonin and long-term prognosis after an admission for acute heart failure
Villanueva, M. P., Mollar, A., Palau, P., Carratalá, A., Núñez, E., Santas, E., Bodı́, V., Chorro, F. J., Miñana, G., Blasco, M. L., et al. (2015) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2014.12.009 · Cited by 30
Serum Neprilysin and Recurrent Admissions in Patients With Heart Failure
Núñez, J. E., Núñez, E., Barallat, J., Bodı́, V., Miñana, G., Pastor, M. C., Sanchís, J. M., Lupón, J., & Bayés‐Genís, A. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005712 · Cited by 30
Modeling marginal features in studies of recurrent events in the presence of a terminal event
Andersen, P. K., Angst, J., & Ravn, H. (2019) · Lifetime Data Analysis · doi:10.1007/s10985-019-09462-4 · Cited by 29
Estimands for Recurrent Event Endpoints in the Presence of a Terminal Event
Schmidli, H., Roger, J., & Akacha, M. (2021) · Statistics in Biopharmaceutical Research · doi:10.1080/19466315.2021.1895883 · Cited by 34
Pharmacological interventions for heart failure in people with chronic kidney disease
Lunney, M., Ruospo, M., Natale, P., Quinn, R. R., Ronksley, P. E., Konstantinidis, I., Palmer, S. C., Tonelli, M. A., Strippoli, G. F., & Ravani, P. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012466.pub2 · Cited by 33
Heart Failure With “Mid-Range” Ejection Fraction—New Opportunities
Lund, L. H. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2016.07.439 · Cited by 30
Jhund, P. S., Claggett, B. L., Talebi, A., Butt, J. H., Gasparyan, S. B., Wei, L., McCaw, Z. R., Wilderäng, U., Bengtsson, O., Desai, A. S., et al. (2023) · JAMA Cardiology · doi:10.1001/jamacardio.2023.0711 · Cited by 34
Self-citationYamamoto, S., Matsuzawa, R., Hoshi, K., Suzuki, Y., Harada, M., Watanabe, T., Isobe, Y., Imamura, K., Osada, S., Yoshida, A., et al. (2020) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2020.08.006 · Cited by 28
Rauch, G., Kieser, M., Binder, H., Bayés‐Genís, A., & Jahn‐Eimermacher, A. (2018) · Clinical Research in Cardiology · doi:10.1007/s00392-018-1205-7 · Cited by 28
Jahn‐Eimermacher, A., Ingel, K., Preussler, S., Bayés‐Genís, A., & Binder, H. (2017) · BMC Medical Research Methodology · doi:10.1186/s12874-017-0366-9 · Cited by 27
Analysing adverse events by time‐to‐event models: the CLEOPATRA study
Proctor, T., & Schumacher, M. C. (2016) · Pharmaceutical Statistics · doi:10.1002/pst.1758 · Cited by 27
Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure
Marinescu, M. C., Oprea, V. D., Munteanu, S. N., Nechita, A., Tutunaru, D., Nechita, L., & Romila, A. (2024) · Diagnostics · doi:10.3390/diagnostics14080795 · Cited by 26
Functional tricuspid regurgitation and recurrent admissions in patients with acute heart failure
de la Espriella, R., Santas, E., Chorro, F. J., Miñana, G., Soler, M., Bodı́, V., Valero, E., Núñez, E., Bayés‐Genís, A., Lupón, J., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.03.051 · Cited by 26
Furberg, J. K., Rasmussen, S., Andersen, P. K., & Ravn, H. (2021) · Pharmaceutical Statistics · doi:10.1002/pst.2167 · Cited by 30
Levitan, E. B., Muntner, P., Chen, L., Deng, L., Kilgore, M. L., Becker, D. J., Glasser, S. P., Safford, M. M., Howard, G., Kilpatrick, R. D., et al. (2016) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6653-6 · Cited by 26
Days alive out of hospital in heart failure: Insights from the PARADIGM-HF and CHARM trials
Chen, Y., Lawrence, J., & Stockbridge, N. (2021) · American Heart Journal · doi:10.1016/j.ahj.2021.03.016 · Cited by 25
Tay, W. T., Teng, T. K., Simon, O., Ouwerkerk, W., Tromp, J., Doughty, R. N., Richards, A. M., Hung, C., Qin, Y., Aung, T., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021414 · Cited by 25
Quantifying Treatment Effects in Trials with Multiple Event-Time Outcomes
Claggett, B. L., McCaw, Z. R., Tian, L., McMurray, J. J. V., Jhund, P. S., Uno, H., Pfeffer, M. A., Solomon, S. D., & Wei, L. (2022) · NEJM Evidence · doi:10.1056/evidoa2200047 · Cited by 28
Self-citationPolsinelli, V. B., & Shah, S. J. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1288717 · Cited by 23
Feuerstein, A., Schoenrath, F., Knierim, J., Friede, T., Verheyen, N., Mehra, M. R., Haykowsky, M. J., Herrmann‐Lingen, C., Duvinage, A., Pieske‐Kraigher, E., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1431 · Cited by 23
Kurita, N., Akizawa, T., & Fukuhara, S. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.10.001 · Cited by 22
Fritsch, A., Schloemer, P., Mendolia, F., Mütze, T., Jahn‐Eimermacher, A., & on behalf of the Recurrent Event Qualification Opinion Consortium (2021) · Statistics in Biopharmaceutical Research · doi:10.1080/19466315.2021.1945488 · Cited by 23
Metadata
- Authors
- Rogers, J. K., Pocock, S. J., McMurray, J. J. V., Granger, C. B., Michelson, E. L., Östergren, J., Pfeffer, M. A., Solomon, S. D., Swedberg, K., & Yusuf, S.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- University of Glasgow (GB)
- Duke University (US)
- AstraZeneca (United States) (US)
- Karolinska University Hospital (SE)
- Brigham and Women's Hospital (US)
- Imperial College London (GB)
- Hamilton Health Sciences (CA)
- Corresponding author
- Rogers, Jennifer K.
- ORCID
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-12-18
- Volume
- 16
- Issue
- 1
- Pages
- 33-40
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- PMC
- PMC4822681
- OpenAlex
- W1870916828
- Cited by
- 226
- References
- 26
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 15 · 2023: 20 · 2022: 23 · 2021: 28 · 2020: 11 · 2019: 20 · 2018: 21 · 2017: 26 · 2016: 23 · 2015: 13 · 2014: 8 · 2013: 2
- FWCI
- 10.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- AstraZeneca
- National Institute for Health and Care Research (PDF-2013-06-024)
- Medical Research Council (MC_EX_G0800814)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Keywords
- heart failure, recurrent hospitalization, heart failure with preserved ejection fraction, candesartan, Andersen-Gill model, negative binomial regression, Poisson regression, win ratio, treatment benefit, cardiovascular mortality
- MeSH terms
- Data Interpretation, Statistical, Heart Failure, Hospitalization, Humans, Morbidity, Global Health, Survival Rate, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
