Cited by 76Cardiovascular Function and Risk FactorsHeart Failure Treatment and ManagementCardiovascular Health and Disease Prevention

Left Ventricular Ejection Time is an Independent Predictor of Incident Heart Failure in a Community-Based Cohort

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Biering-Sørensen, Tor, Querejeta Roca, Gabriela, Hegde, Sheila M., Shah, Amil M., Claggett, Brian, Mosley, Thomas H., Butler, Kenneth R., Solomon, Scott D.·2018·European Journal of Heart Failure

Abstract

Aims: Systolic time intervals change in the progress of cardiac dysfunction. The usefulness of left ventricular ejection time (LVET) to predict cardiovascular morbidity, however, is unknown. Methods and results: We studied middle-aged African-Americans from one of four cohorts of the Atherosclerosis Risk in Communities study (Jackson cohort, n=1980) who underwent echocardiography between 1993 and 1995. Left ventricular ejection time was measured by pulsed-wave Doppler of the left ventricular outflow tract and related to outcomes. A shorter LVET was associated with younger age, male sex, higher diastolic blood pressure, higher proportion of diabetes, higher heart rate, higher blood glucose levels and worse fractional shortening. During a median follow-up of 17.6 years, 384 (19%) had incident heart failure (HF), 158 (8%) had a myocardial infarction, and 587 (30%) died. In univariable analysis, a lower LVET was significantly associated with increased risk of all events (P<0.05 for all). However, after multivariable adjustment for age, sex, hypertension, diabetes, body mass index, heart rate, systolic and diastolic blood pressure, fractional shortening and left atrial diameter, LVET remained an independent predictor only of incident HF [hazard ratio 1.07 (1.02–1.14), P=0.010 per 10 ms decrease]. In addition, LVET provided incremental prognostic information to the known risk factors included in the Framingham risk score, in regard to predicting all outcomes except for myocardial infarction. Conclusion: Left ventricular ejection time is an independent predictor of incident HF in a community-based cohort and provides incremental prognostic information on the risk of future HF and death when added to known risk prediction models.

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  1. [28]The Stata Journal - sjpdf.html.
  2. [32]Tei C, Dujardin KS, Hodge DO, Kyle RA, Tajik AJ, Seward JB. Doppler index combining systolic and diastolic myocardial performance: clinical value in cardiac amyloidosis. J Am Coll Cardiol 1996; 28: 658– 664. 8772753

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Authors
Biering-Sørensen, T., Querejeta Roca, G., Hegde, S. M., Shah, A. M., Claggett, B., Mosley, T. H., Butler, K. R., & Solomon, S. D.
Affiliations
  • Cardiovascular Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA ,
  • Brigham and Women's Hospital (US)
  • University of Mississippi Medical Center (US)
Corresponding author
Solomon, Scott D.
Venue
European Journal of Heart Failure
Published
2017-09-04
Volume
20
Issue
7
Pages
1106-1114
ISSN
  • 1388-9842 (ISSN-L)
  • 1879-0844
OpenAlex
W2752678285
Cited by
76
References
44
Citations by year
2026: 4 · 2025: 8 · 2024: 13 · 2023: 9 · 2022: 14 · 2021: 10 · 2020: 12 · 2019: 4 · 2018: 2
FWCI
3.81
Type
journal article
Language
en
Open access
Locations
  • European Journal of Heart Failure (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
left ventricular ejection time, systolic time intervals, heart failure, incident heart failure, prognostic factors, African Americans, Atherosclerosis Risk in Communities Study, myocardial infarction, mortality, Framingham risk score, left ventricular function, fractional shortening
MeSH terms
Black or African American, Echocardiography, Female, Follow-Up Studies, Heart Failure, Heart Ventricles, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Stroke Volume, United States, Incidence, Survival Rate, Ventricular Function, Left

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