The DOI matches its Crossref record.
Interleukin 1 and poly(rI) · poly(rC) induce production of a hybridoma growth factor by human fibroblasts
Abstract
Cultures of normal diploid fibroblasts and of a human osteosarcoma cell line (MG‐63) are shown to be able to produce a factor which promotes the growth of B cell hybridomas (hybridoma growth factor, HGF). The induction is stimulated by treatment of the cells with interleukin 1 (IL 1) (α or β) or polyriboinosinic‐polyribocytidylic acid [poly(rI) · poly(rC)]. Combined treatment with cycloheximide and actinomycin D also stimulates production and enhances production induced by IL 1 or poly(rI) · poly(rC). Extremely small doses of IL 1 (0.1 units/ml) are active as inducer of HGF. Also, under optimal conditions the yield of HGF can attain as much as 10 4 units/ml. Tumor necrosis factor (TNF‐α), which otherwise shares various properties with IL 1, is a weak inducer of HGF. Although there is a superficial resemblance between induction of HGF and that of interferon‐β, the two activities are serologically distinct and conditions for their induction are quite different. In fact, conditions for induction of HGF are indistinguishable from those described for the induction of the mRNA of the so‐called 26‐kDa protein (also known as interferon‐β 2). Finally, the HGF derived from IL 1‐ or poly(rI) ‐ poly(rC)‐treated fibroblasts is serologically not distinguishable from that produced by mitogen‐stimulated peripheral blood leukocytes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
“Since IL-1 can induce IL-6 production in fibroblasts, thymocytes, and monocytes (34-36), it is, for example, possible that the partial inhibition of ID6 production is the result of reduced Ibl production.”
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Van Snick, J. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001345 · Cited by 1,890
Self-citationGauldie, J., Richards, C., Harnish, D., Lansdorp, P., & Baumann, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7251 · Cited by 1,635
Houssiau, F. A., Devogelaer, J., Damme, J. V., Deuxchaisnes, C. N. D., & Snick, J. V. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310614 · Cited by 847
Metadata
- Authors
- Van Damme, J., Cayphas, S., Opdenakker, G., Billiau, A., & Van Snick, J.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1987-01
- Volume
- 17
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2064264428
- Cited by
- 172
- References
- 0
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Interleukin 1 and poly(rI) · poly(rC) induce production of a hybridoma growth factor by human fibroblasts. https://app.cochat.ai/papers/10.1002/eji.1830170102
- The paper
- Van Damme, J., Cayphas, S., Opdenakker, G., Billiau, A., & Van Snick, J. (1987). Interleukin 1 and poly(rI) · poly(rC) induce production of a hybridoma growth factor by human fibroblasts. European Journal of Immunology. https://doi.org/10.1002/eji.1830170102
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
