The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Functional evidence that intercellular adhesion molecule‐1 (icam‐1) is a ligand for lfa‐1d‐ependent adhesion in t cell‐mediated cytotoxicity
Abstract
Although intercellular adhesion molecule‐1 (ICAM‐1) has been implicated as a ligand in some LFA‐1‐dependent adhesion, its importance to T cell function has not been established. The present studies investigate the importance of ICAM‐1 for human cytotoxic T lymphocytes (CTL), both in their formation of antigen‐independent conjugates (AIC) and in their lysis of targets. Analysis of monoclonal antibody (mAb) inhibition of AIC formation indicate that ICAM‐1 mAb 1 blocks (a) AIC formation with some but not all targets; (b)the LFA‐1 pathway but not the CD2LFA‐3 pathway of adhesion; (c) by binding to the target cell, not the T cell. In studies of cell‐mediated lysis (CML) ICAM‐1 mAb inhibited lysis of some targets, such as U‐937, that use ICAM‐1 predominantly in AIC formation; CML on some other targets is not inhibited by ICAM‐1 mAb. These data indicate that ICAM‐1 is a ligand for AIC formation, antigen‐specific CTL recognition and cytolysis of particular target cells. The data also indicate that ICAM‐1 is not used in LFA‐1‐dependent CTL interactions with all kinds of target cells, suggesting the existence of alternative ligands for LFA‐1.
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Citations
Cites
Integrins: A family of cell surface receptors
HYNES, R. (1987) · Cell · doi:10.1016/0092-8674(87)90233-9 · Cited by 4,249
Dustin, M. L., Rothlein, R., Bhan, A. K., Dinarello, C. A., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.1.245 · Cited by 2,450
Self-citationMarlin, S. D., & Springer, T. A. (1987) · Cell · doi:10.1016/0092-8674(87)90104-8 · Cited by 1,674
Self-citationA human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.
Rothlein, R., Dustin, M. L., Marlin, S. D., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.4.1270 · Cited by 1,400
Self-citationSpringer, T. (1987) · Annual Review of Immunology · doi:10.1146/annurev.immunol.5.1.223 · Cited by 1,110
Self-citationSanchez-Madrid, F., Krensky, A. M., Ware, C. F., Robbins, E., Strominger, J. L., Burakoff, S. J., & Springer, T. A. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7489 · Cited by 718
Self-citationICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells
Makgoba, M. W., Sanders, M. E., Luce, G. E. G., Dustint, M. L., Springer, T. A., Clark, E. A., Mannoni, P., & Shaw, S. (1988) · Nature · doi:10.1038/331086a0 · Cited by 573
Self-citationThe T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3
Selvaraj, P., Plunkett, M. L., Dustin, M., Sanders, M. E., Shaw, S., & Springer, T. A. (1987) · Nature · doi:10.1038/326400a0 · Cited by 442
Self-citationTwo antigen-independent adhesion pathways used by human cytotoxic T-cell clones
Shaw, S., Ginther Luce, G. E., Quinones, R., Gress, R. E., Springer, T. A., & Sanders, M. E. (1986) · Nature · doi:10.1038/323262a0 · Cited by 426
Self-citationPurified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.
Dustin, M. L., Sanders, M. E., Shaw, S., & Springer, T. A. (1987) · The Journal of experimental medicine · doi:10.1084/jem.165.3.677 · Cited by 253
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Cited by
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Self-citationA cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses
Staunton, D. E., Merluzzi, V. J., Rothlein, R., Barton, R., Marlin, S. D., & Springer, T. A. (1989) · Cell · doi:10.1016/0092-8674(89)90689-2 · Cited by 821
Self-citationA β 3 Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation
Loftus, J. C., O'Toole, T. E., Plow, E. F., Glass, A., Frelinger, A. L., & Ginsberg, M. H. (1990) · Science · doi:10.1126/science.2392682 · Cited by 401
Metadata
- Authors
- Makgoba, M. W., Sanders, M. E., Luce, G. E. G., Gugel, E. A., Dustin, M. L., Springer, T. A., & Shaw, S.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1988-04
- Volume
- 18
- Issue
- 4
- Pages
- 637-640
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2117837558
- Cited by
- 313
- References
- 13
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Functional evidence that intercellular adhesion molecule‐1 (icam‐1) is a ligand for lfa‐1d‐ependent adhesion in t cell‐mediated cytotoxicity. https://app.cochat.ai/papers/10.1002/eji.1830180423
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- Makgoba, M. W., Sanders, M. E., Luce, G. E. G., Gugel, E. A., Dustin, M. L., Springer, T. A., & Shaw, S. (1988). Functional evidence that intercellular adhesion molecule‐1 (icam‐1) is a ligand for lfa‐1d‐ependent adhesion in t cell‐mediated cytotoxicity. European Journal of Immunology. https://doi.org/10.1002/eji.1830180423
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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