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Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.
Open accessAbstract
CD2 is a T lymphocyte glycoprotein that functions in adhesion of T lymphocytes and also as a putative receptor for activation signals. Functional data suggest that LFA-3, a widely distributed cell surface glycoprotein, may be the biological ligand of CD2. We have purified LFA-3 from human erythrocytes and characterized the purified protein functionally. LFA-3 bound specifically to CD2+ cells, and this binding was inhibited by CD2 mAb. Conversely, purified LFA-3 inhibited binding of CD2 mAb to cells, and the concentration required for this effect suggests that LFA-3 half-saturated CD2 at 1-5 nM LFA-3. Purified LFA-3 inhibited rosetting of human and sheep erythrocytes with CD2+ T lymphoma cells and T lymphocytes, and mediated aggregation of a CD2+ T lymphoma cell line. Purified LFA-3 reconstituted into planar membranes mediated efficient CD2-dependent adhesion of T lymphoblasts. These data demonstrate that LFA-3 is a ligand for CD2 and that LFA-3 can mediate T lymphocyte adhesion.
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Citations
Cited by
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Self-citationLanier, L. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.359 · Cited by 1,648
Makgoba, M. W., Sanders, M. E., Luce, G. E. G., Gugel, E. A., Dustin, M. L., Springer, T. A., & Shaw, S. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180423 · Cited by 313
Self-citationLFA-3, CD44, and CD45: Physiologic Triggers of Human Monocyte TNF and IL-1 Release
Webb, D. S. A., Shimizu, Y., Van Seventer, G. A., Shaw, S., & Gerrard, T. L. (1990) · Science · doi:10.1126/science.1697984 · Cited by 287
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Metadata
- Authors
- Dustin, M. L., Sanders, M. E., Shaw, S., & Springer, T. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1987-03-01
- Volume
- 165
- Issue
- 3
- Pages
- 677-692
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2155740187
- Cited by
- 253
- References
- 0
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. https://app.cochat.ai/papers/10.1084/jem.165.3.677
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- Dustin, M. L., Sanders, M. E., Shaw, S., & Springer, T. A. (1987). Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. The Journal of experimental medicine. https://doi.org/10.1084/jem.165.3.677
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