CoChat
Sign Up
Cited by 665Immune Response and InflammationGenetics, Aging, and Longevity in Model OrganismsT-cell and B-cell Immunology

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Increased cytokine production in mononuclear cells of healthy elderly people

Open access
Fagiolo, Umberto, Cossarizza, Andrea, Scala, Enrico, Fanales‐Belasio, Emanuele, Ortolani, Claudio, Cozzi, Emanuele, Monti, Daniela, Franceschi, Claudio, Paganelli, Roberto·1993·European Journal of Immunology
DOI 10.1002/eji.1830230950
Open this paper in CoChat — free account

Abstract

The production of cytokines during aging, except interleukin (IL)‐2, has been neglected in humans. We measured the in vitro production of IL‐6, tumor necrosis factor (TNF)‐α, interferon (IFN)‐γ and IL‐1β by peripheral mononuclear cells from selected healthy young (mean age 26.8 years) and aged (mean age 80.2 years) subjects. Significant increases of IL‐6, TNF‐α and IL‐1bT levels were found in mitogen‐stimulated cultures from aged donors, occurring at 24 to 72 h after stimulation. No significant differences were observed for IFN‐γ production. Proliferative capability of cells stimulated with PHA was not impaired in aged subjects. Since the amounts of all cytokines studied were similar in unstimulated cultures from young and aged subjects, and also serum levels of TNF‐a did not differ, these data indicate that the cellular machinery for the production of these cytokines is well preserved in aging, and also that cells from old people are able to up‐regulate their production in response to appropriate stimuli. The increases in cytokine synthesis were not dependent on changes in the number of monocytes, nor were they related to the significant rise of CD45RO+, and the concomitant decrease of CD45RA+ occurring in both CD4+ and CD8+ lymphocytes from aged subjects. The increased production of pro‐inflammatory cytokines by stimulated mononuclear cells of healthy aged subjects may be relevant to several aspects of age‐associated pathological events, including atherosclerosis, osteoporosis, fibrosis and dementia.

Overview

Integrity signals

Registry

Crossref · 10.1002/eji.1830230950

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Citations

Cites

Flagged first, then by citations

Show all 23 references

Research works printed but not linked: 3

  1. Goldberg H., 1991, Aging Immunol. Infect. Dis., 3, 81
  2. Cossarizza A., 1992, J. Immunol. Res., 4, 118
  3. Beverley P. C. L., 1992, Semin. Immunol., 4, 35

Cited by

Sorted by citations

Items 401–500 of 664

Related

See all

Metadata

Authors
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R.
Affiliations
  • University of Padua (IT)
  • University of Modena and Reggio Emilia (IT)
  • Sapienza University of Rome (IT)
Corresponding author
Franceschi, Claudio
ORCID
Venue
European Journal of Immunology
Publisher
Wiley
Published
1993-09
Volume
23
Issue
9
Pages
2375-2378
ISSN
  • 0014-2980 (ISSN-L)
  • 1521-4141
DOI
10.1002/eji.1830230950
OpenAlex
W2072622521
Cited by
665
References
23
Citations by year
2026: 11 · 2025: 7 · 2024: 8 · 2023: 17 · 2022: 25 · 2021: 27 · 2020: 18 · 2019: 34 · 2018: 21 · 2017: 30 · 2016: 24 · 2015: 22 · 2014: 16 · 2013: 26 · 2012: 13
FWCI
3.09
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
aging, cytokine production, inflammatory cytokines, interleukin-6, TNF-α, IL-1β, interferon-gamma, peripheral blood mononuclear cells, mitogen stimulation, lymphocyte proliferation, healthy older adults, age-related diseases
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Cells, Cultured, Female, Humans, Interleukin-1, Leukocytes, Mononuclear, Male, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Leukocyte Common Antigens

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review