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Cited by 665Immune Response and InflammationGenetics, Aging, and Longevity in Model OrganismsT-cell and B-cell Immunology

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Increased cytokine production in mononuclear cells of healthy elderly people

Open access
Fagiolo, Umberto, Cossarizza, Andrea, Scala, Enrico, Fanales‐Belasio, Emanuele, Ortolani, Claudio, Cozzi, Emanuele, Monti, Daniela, Franceschi, Claudio, Paganelli, Roberto·1993·European Journal of Immunology
DOI 10.1002/eji.1830230950
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Abstract

The production of cytokines during aging, except interleukin (IL)‐2, has been neglected in humans. We measured the in vitro production of IL‐6, tumor necrosis factor (TNF)‐α, interferon (IFN)‐γ and IL‐1β by peripheral mononuclear cells from selected healthy young (mean age 26.8 years) and aged (mean age 80.2 years) subjects. Significant increases of IL‐6, TNF‐α and IL‐1bT levels were found in mitogen‐stimulated cultures from aged donors, occurring at 24 to 72 h after stimulation. No significant differences were observed for IFN‐γ production. Proliferative capability of cells stimulated with PHA was not impaired in aged subjects. Since the amounts of all cytokines studied were similar in unstimulated cultures from young and aged subjects, and also serum levels of TNF‐a did not differ, these data indicate that the cellular machinery for the production of these cytokines is well preserved in aging, and also that cells from old people are able to up‐regulate their production in response to appropriate stimuli. The increases in cytokine synthesis were not dependent on changes in the number of monocytes, nor were they related to the significant rise of CD45RO+, and the concomitant decrease of CD45RA+ occurring in both CD4+ and CD8+ lymphocytes from aged subjects. The increased production of pro‐inflammatory cytokines by stimulated mononuclear cells of healthy aged subjects may be relevant to several aspects of age‐associated pathological events, including atherosclerosis, osteoporosis, fibrosis and dementia.

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Research works printed but not linked: 3

  1. Goldberg H., 1991, Aging Immunol. Infect. Dis., 3, 81
  2. Cossarizza A., 1992, J. Immunol. Res., 4, 118
  3. Beverley P. C. L., 1992, Semin. Immunol., 4, 35

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Metadata

Authors
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R.
Affiliations
  • University of Padua (IT)
  • University of Modena and Reggio Emilia (IT)
  • Sapienza University of Rome (IT)
Corresponding author
Franceschi, Claudio
ORCID
Venue
European Journal of Immunology
Publisher
Wiley
Published
1993-09
Volume
23
Issue
9
Pages
2375-2378
ISSN
  • 0014-2980 (ISSN-L)
  • 1521-4141
DOI
10.1002/eji.1830230950
OpenAlex
W2072622521
Cited by
665
References
23
Citations by year
2026: 11 · 2025: 7 · 2024: 8 · 2023: 17 · 2022: 25 · 2021: 27 · 2020: 18 · 2019: 34 · 2018: 21 · 2017: 30 · 2016: 24 · 2015: 22 · 2014: 16 · 2013: 26 · 2012: 13
FWCI
3.09
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
aging, cytokine production, inflammatory cytokines, interleukin-6, TNF-α, IL-1β, interferon-gamma, peripheral blood mononuclear cells, mitogen stimulation, lymphocyte proliferation, healthy older adults, age-related diseases
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Cells, Cultured, Female, Humans, Interleukin-1, Leukocytes, Mononuclear, Male, Tumor Necrosis Factor-alpha, Interleukin-6, Cytokines, Leukocyte Common Antigens

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