The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells
Abstract
Most of the immunosuppressive effects of interleukin‐10 (IL‐10) are related to functional inhibition of antigen‐presenting cells (APC). Herein, we investigate the influence of recombinant (r)IL‐10 on human dendritic cells (DC) purified from peripheral blood of healthy volunteers. First, we found that rIL‐10 inhibited in a dose‐dependent manner the proliferative responses as well as the production of IL‐2 and interferon‐γ (IFN‐γ) in mixed lymphocyte reaction (MLR) between purified T cells and DC. This rIL‐10 effect could be attributed to a direct effect on DC, as DC preincubated with rIL‐10 were found to be deficient in the induction of alloreactive T cells even when anti‐IL‐10 neutralizing mAb was added at the time of MLR. Flow cytometric analysis indicated that rIL‐10 did not modify the expression of ICAM‐1 (CD54) and B7‐1 (CD80), but decreased HLA‐DR and B7‐2 (CD86) expression at the DC surface. We conclude that the inhibitory effect of rIL‐10 on primary alloreactive T cell responses involves down‐regulation of class II MHC and B7‐2 expression at the DC surface.
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Cites
Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28
Fraser, J. D., Irving, B. A., Crabtree, G. R., & Weiss, A. (1991) · Science · doi:10.1126/science.1846244 · Cited by 641
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Wolf, A. M., Wolf, D., Rumpold, H., Enrich, B., & Tilg, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.145 · Cited by 819
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
Gottfried, E., Kunz-Schughart, L. A., Ebner, S., Mueller-Klieser, W., Hoves, S., Andreesen, R., Mackensen, A., & Kreutz, M. (2006) · Blood · doi:10.1182/blood-2005-05-1795 · Cited by 729
Menetrier-Caux, C., Montmain, G., Dieu, M. C., Bain, C., Favrot, M. C., Caux, C., & Blay, J. Y. (1998) · Blood · doi:10.1182/blood.v92.12.4778 · Cited by 590
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice
Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B., Thielen, C., Gustin, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39717 · Cited by 399
Kaliński, P., Schuitemaker, J. H. N., Hilkens, C. M. U., & Kapsenberg, M. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.2804 · Cited by 371
Metadata
- Authors
- Buelens, C., Willems, F., Delvaux, A., Piérard, G., Delville, J., Velu, T., & Goldman, M.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 1995-09
- Volume
- 25
- Issue
- 9
- Pages
- 2668-2672
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2092117527
- Cited by
- 274
- References
- 1
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells. https://app.cochat.ai/papers/10.1002/eji.1830250940
- The paper
- Buelens, C., Willems, F., Delvaux, A., Piérard, G., Delville, J., Velu, T., & Goldman, M. (1995). Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells. European Journal of Immunology. https://doi.org/10.1002/eji.1830250940
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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