Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor
Abstract
The escape of malignant cells from the immune response against the tumor may result from a defective differentiation or function of professional antigen-presenting cells (APC), ie, dendritic cells (DC). To test this hypothesis, the effect of human renal cell carcinoma cell lines (RCC) on the development of DC from CD34(+) progenitors was investigated in vitro. RCC cell lines were found to release soluble factors that inhibit the differentiation of CD34(+) cells into DC and trigger their commitment towards monocytic cells (CD14(+)CD64(+)CD1a-CD86(-)CD80(-)HLA-D Rlow) with a potent phagocytic capacity but lacking APC function. RCC CM were found to act on the two distinct subpopulations emerging in the culture at day 6 ([CD14(+)CD1a-] and [CD14(-)CD1a+]) by inhibiting the differentiation into DC of [CD14(+)CD1a-] precursors and blocking the acquisition of APC function of the [CD14(-)CD1a+] derived DC. Interleukin-6 (IL-6) and macrophage colony-stimulating factor (M-CSF) were found to be responsible for this phenomenon: antibodies against IL-6 and M-CSF abrogated the inhibitory effects of RCC CM; and recombinant IL-6 and/or M-CSF inhibited the differentiation of DC similarly to RCC CM. The inhibition of DC differentiation by RCC CM was preceeded by an induction of M-CSF receptor (M-CSFR; CD115) and a loss of granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR; CD116) expression at the surface of CD34(+) cells, two phenomenon reversed by anti-IL-6/IL-6R and anti-M-C…
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CSF-2 in isolation also promotes differentiation of monocytes into a dendritic cell lineage, which maintains a phagocytic phenotype (CD68 immunopositive).
“CSF-2 in isolation also promotes their differentiation into a dendritic cell lineage, which maintains a phagocytic phenotype (CD68 immunopositive) [17, 30].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [30]
Cites
The Dendritic Cell System and its Role in Immunogenicity
Steinman, R. M. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001415 · Cited by 4,659 · see citing works
Gabrilovich, D. I., Chen, H. L., Girgis, K. R., Cunningham, H. T., Meny, G. M., Nadaf, S., Kavanaugh, D., & Carbone, D. P. (1996) · Nature Medicine · doi:10.1038/nm1096-1096 · Cited by 1,977 · see citing works
Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells
Hsu, F. J., Benike, C., Fagnoni, F., Liles, T. M., Czerwinski, D., Taidi, B., Engleman, E. G., & Levy, R. (1996) · Nature Medicine · doi:10.1038/nm0196-52 · Cited by 1,804 · see citing works
GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
Caux, C., Dezutter‐Dambuyant, C., Schmitt, D., & Banchereau, J. (1992) · Nature · doi:10.1038/360258a0 · Cited by 1,551 · see citing works
Self-citationSchwartz, R. H. (1992) · Cell · doi:10.1016/s0092-8674(05)80055-8 · Cited by 1,293 · see citing works
Induction of tolerance by IL-10-treated dendritic cells
Steinbrink, K., Wölfl, M., Jonuleit, H., Knop, J., & Enk, A. H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.10.4772 · Cited by 1,245 · see citing works
Caux, C., Vanbervliet, B., Massacrier, C., Dezutter‐Dambuyant, C., de Saint-Vis, B., Jacquet, C., Yoneda, K., Imamura, S., Schmitt, D., & Banchereau, J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.695 · Cited by 920 · see citing works
Self-citationZitvogel, L., Mayordomo, J. I., Tjandrawan, T., DeLeo, A. B., Clarke, M. R., Lotze, M. T., & Storkus, W. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.87 · Cited by 828 · see citing works
Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.
Zhou, L., & Tedder, T. F. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.8.3821 · Cited by 751 · see citing works
Kawasaki, E. S., Ladner, M. B., Wang, A. M., Arsdell, J. V., Warren, M. K., Coyne, M. Y., Schweickart, V. L., Lee, M.-T., Wilson, K. J., Boosman, A., et al. (1985) · Science · doi:10.1126/science.2996129 · Cited by 522 · see citing works
CSF‐1—A mononuclear phagocyte lineage‐specific hemopoietic growth factor
Stanley, E. R., Guilbert, L. J., Tushinski, R. J., & Bartelmez, S. H. (1983) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240210206 · Cited by 516 · see citing works
(1996) · Nature Medicine · doi:10.1038/nm1196-1267 · Cited by 431 · see citing works
Reid, C. D. L., Stackpoole, A., Meager, A., & Tikerpae, J. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.8.2681 · Cited by 424 · see citing works
Serum level of interleukin 6 as a prognosis factor in metastatic renal cell carcinoma.
Blay, J., Négrier, S., Combaret, V., Attali, S., Goillot, E., Merrouche, Y., Mercatello, A., Ravault, A., Tourani, J. M., & Jf, M. (1992) · PubMed · Cited by 420 · see citing works
Self-citationRosenberg, S. A., Lotze, M. T., Yang, J., Linehan, W. M., Seipp, C. A., Calabro, S., Karp, S. E., Sherry, R. M., Steinberg, S. M., & White, D. E. (1989) · Journal of Clinical Oncology · doi:10.1200/jco.1989.7.12.1863 · Cited by 372 · see citing works
The host—tumor immune conflict: from immunosuppression to resistance and destruction
Chouaı̈b, S., Asselin‐Paturel, C., Mami‐Chouaib, F., Caignard, A., & Blay, J. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01115-8 · Cited by 350 · see citing works
Self-citationDifferentiation of human dendritic cells from monocytes in vitro
Chapuis, F., Rosenzwajg, M., Yagello, M., Ekman, M., Biberfeld, P., & Gluckman, J. C. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270213 · Cited by 338 · see citing works
TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors
Strobl, H., Riedl, E., Scheinecker, C., Bello-Fernández, C., Pickl, W. F., Rappersberger, K., Majdic, O., & Knapp, W. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.4.1499 · Cited by 300 · see citing works
Buelens, C., Willems, F., Delvaux, A., Piérard, G. E., Delville, J., Velu, T., & Goldman, M. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250940 · Cited by 275 · see citing works
TRAIL/Apo-2-ligand-induced apoptosis in human T cells
Jeremias, I., Herr, I., Böhler, T., & Debatin, K. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199801)28:01 · Cited by 265 · see citing works
Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor
Blay, J., Burdin, N., Rousset, F., Lenoir, G., Biron, P., Philip, T. O., Banchereau, J., & Favrot, M. (1993) · Blood · doi:10.1182/blood.v82.7.2169.2169 · Cited by 247 · see citing works
Self-citationDifferential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production
Macatonia, S. E., Doherty, T. M., Knight, S. C., & O’Garra, A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.9.3755 · Cited by 242 · see citing works
Buelens, C., Verhasselt, V., Groote, D. D., Thielemans, K., Goldman, M., & Willems, F. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270326 · Cited by 237 · see citing works
Szabolcs, P., Avigan, D., Gezelter, S., Ciocon, D., Moore, M., Steinman, R. M., & Young, J. W. (1996) · Blood · doi:10.1182/blood.v87.11.4520.bloodjournal87114520 · Cited by 218 · see citing works
Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells
Caux, C., Massacrier, C., Vanbervliet, B., Barthélémy, C., Liu, Y.-J., & Banchereau, J. (1994) · International Immunology · doi:10.1093/intimm/6.8.1177 · Cited by 192 · see citing works
Self-citationIL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells.
Beissert, S., Hosoi, J., Grabbe, S., Asahina, A., & Granstein, R. D. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.3.1280 · Cited by 184 · see citing works
Knight, S. C., & Stagg, A. J. (1993) · Current Opinion in Immunology · doi:10.1016/0952-7915(93)90056-x · Cited by 181 · see citing works
Schendel, D. J., Gänsbacher, B., Oberneder, R., Kriegmair, M., Hofstetter, A. G., Riethmüller, G., & Segurado, O. G. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.8.4209 · Cited by 157 · see citing works
Mitra, R. S., Judge, T. A., Nestle, F. O., Turka, L. A., & Nickoloff, B. J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2668 · Cited by 156 · see citing works
Interleukin‐10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells
Péguet‐Navarro, J., Moulon, C., Caux, C., Dalbiez‐Gauthier, C., Banchereau, J., & Schmitt, D. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240416 · Cited by 144 · see citing works
Self-citationBrändle, D., Brasseur, F., Weynants, P., Boon, T., & den Eynde, B. J. V. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2501 · Cited by 143 · see citing works
Bone Marrow‐Derived Dendritic Cells Serve as Potent Adjuvants for Peptide‐Based Antitumor Vaccines
Mayordomo, J. I., Zorina, T. D., Storkus, W. J., Zitvogel, L., García-Prats, M. D., DeLeo, A. B., & Lotze, M. T. (1997) · Stem Cells · doi:10.1002/stem.150094 · Cited by 136 · see citing works
Émilie, D., Wijdenes, J., Gisselbrecht, C., Jarrousse, B., Billaud, É., Blay, J., Gabarre, J., Gaillard, J., Brochier, J., & Raphaël, M. (1994) · Blood · doi:10.1182/blood.v84.8.2472.2472 · Cited by 118 · see citing works
Self-citationAprikian, A. G., Tremblay, L., Han, K., & Chevalier, S. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970729)72:3 · Cited by 112 · see citing works
Honda, M., KITAMURA, K., Mizutani, Y., Oishi, M., Arai, M., Okura, T., Igarahi, K., Yasukawa, K., Hirano, T., Kishimoto, T., et al. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.12.4059 · Cited by 102 · see citing works
Tartour, É., Blay, J., Dorval, T., Escudier, B. J., Mosseri, V., Douillard, J., Deneux, L., Gorin, I., Négrier, S., Mathiot, C., et al. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.5.1697 · Cited by 98 · see citing works
Self-citationBot, F., van Eijk, L. T., Broeders, L., Aarden, L. A., & Löwenberg, B. (1989) · Blood · doi:10.1182/blood.v73.2.435.435 · Cited by 91 · see citing works
Jansen, J. H., Kluin‐Nelemans, H. C., Damme, J. V., Wientjens, G. J. H. M., Willemze, R., & Fibbe, W. E. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.4.1151 · Cited by 75 · see citing works
Bernhard, H., Karbach, J., Wölfel, T., Busch, P., Störkel, S., Stöckle, M., Wölfel, C., Seliger, B., Huber, C., Büschenfelde, K. M. Z., et al. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910590621 · Cited by 58 · see citing works
Olweus, J., Thompson, P., & Lund-Johansen, F. (1996) · Blood · doi:10.1182/blood.v88.10.3741.bloodjournal88103741 · Cited by 47 · see citing works
Interleukin-6 and TNFα production in human renal cell carcinoma
Gogusev, J., Augusti, M., Chrétien, Y., & Droz, D. (1993) · Kidney International · doi:10.1038/ki.1993.285 · Cited by 44 · see citing works
In Vitro Regulation of Dendritic Cell Development and Function
Caux, C., & Banchereau, J. (1996) · Blood cell biochemistry · doi:10.1007/978-0-585-31728-1_11 · Cited by 35 · see citing works
Self-citationDeehan, D., Heys, S. D., Simpson, W., Broom, J. I., Franks, C. R., & Eremin, O. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.222 · Cited by 24 · see citing works
Endogenously Produced Interleukin 6 is an Accessory Cytokine for Dendritic Cell Hematopoiesis
Santiago‐Schwarz, F., Tucci, J., & Carsons, S. E. (1996) · Stem Cells · doi:10.1002/stem.140225 · Cited by 22 · see citing works
Local Production of Interleukin 6 by Renal Adenocarcinoma In Vivo
Blay, J., Schemann, S., & Favrot, M. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.3.238 · Cited by 22 · see citing works
Self-citationLahn, M., Kunzmann, R., Köhler, G., Iklé, D. N., Hentrich, I., Jesuiter, H., Kulmburg, P., Veelken, H., Mackensen, A., Rosenthal, F. M., et al. (2009) · Oncology · doi:10.1159/000227730 · Cited by 14 · see citing works
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Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753 · see citing works
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works
Tumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,365 · see citing works
NF-κB: linking inflammation and immunity to cancer development and progression
Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,091 · see citing works
Immunosuppressive networks in the tumour environment and their therapeutic relevance
Zou, W. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1586 · Cited by 2,057 · see citing works
Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000 · see citing works
Almand, B., Clark, J. I., Nikitina, E., van Beynen, J., English, N. R., Knight, S. C., Carbone, D. P., & Gabrilovich, D. I. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.678 · Cited by 1,340 · see citing works
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., Krzysiek, R., Knutson, K. L., Daniel, B., Zimmermann, M. C., et al. (2003) · Nature Medicine · doi:10.1038/nm863 · Cited by 1,314 · see citing works
Colony-stimulating factors in inflammation and autoimmunity
Hamilton, J. A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2356 · Cited by 1,305 · see citing works
Immunological hallmarks of stromal cells in the tumour microenvironment
Turley, S. J., Cremasco, V., & Astarita, J. L. (2015) · Nature Reviews Immunology · doi:10.1038/nri3902 · Cited by 1,140 · see citing works
Mechanisms and functional significance of tumour-induced dendritic-cell defects
Gabrilovich, D. I. (2004) · Nature reviews. Immunology · doi:10.1038/nri1498 · Cited by 1,022 · see citing works
IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
Chomarat, P., Banchereau, J., Davoust, J. M., & Palucka, K. (2000) · Nature Immunology · doi:10.1038/82763 · Cited by 906 · see citing works
Cheng, P., Corzo, C. A., Luetteke, N., Yu, B., Nagaraj, S., Bui, M. M., Ortiz, M. L., Nacken, W. K. F., Sorg, C., Vogl, T., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080132 · Cited by 904 · see citing works
Serafini, P., Borrello, I., & Bronte, V. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.07.005 · Cited by 758 · see citing works
Gobert, M., Treilleux, I., Bendriss-Vermare, N., Bachelot, T., Goddard-Leon, S., Arfi, V., Biota, C., Doffin, A. C., Durand, I., Olive, D., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2360 · Cited by 758 · see citing works
Self-citationNauta, A. J., Kruisselbrink, A. B., Lurvink, E. G. A., Willemze, R., & Fibbe, W. E. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.4.2080 · Cited by 741 · see citing works
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
Gottfried, E., Kunz-Schughart, L. A., Ebner, S., Mueller-Klieser, W., Hoves, S., Andreesen, R., Mackensen, A., & Kreutz, M. (2006) · Blood · doi:10.1182/blood-2005-05-1795 · Cited by 729 · see citing works
Clinical significance of defective dendritic cell differentiation in cancer.
Almand, B., Resser, J. R., Lindman, B. R., Nadaf, S., Clark, J. I., Kwon, E. D., Carbone, D. P., & Gabrilovich, D. I. (2000) · PubMed · Cited by 699 · see citing works
Zou, W., Machelon, V., L’Herminé, A. C., Borvak, J., Mercier‐Nomé, F., Isaeva, T., Wei, S., Krzysiek, R., Durand–Gasselin, I., Gordon, A. N., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1339 · Cited by 653 · see citing works
Bunt, S. K., Yang, L.-L., Sinha, P., Clements, V., Leips, J., & Ostrand-Rosenberg, S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2354 · Cited by 680 · see citing works
Tang, T., Huang, X., Zhang, G., Hong, Z., Bai, X., & Liang, T. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00449-4 · Cited by 613 · see citing works
Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells
Marigo, I., Dolcetti, L., Serafini, P., Zanovello, P., & Bronte, V. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00602.x · Cited by 608 · see citing works
Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment
Fu, C., & Jiang, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03059 · Cited by 602 · see citing works
Deciphering and Reversing Tumor Immune Suppression
Motz, G. T., & Coukos, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.005 · Cited by 600 · see citing works
Collagen as a double-edged sword in tumor progression
Fang, M., Yuan, J., Peng, C., & Li, Y. (2014) · Tumor Biology · doi:10.1007/s13277-013-1511-7 · Cited by 580 · see citing works
Roca, H., Varsos, Z. S., Sud, S., Craig, M. J., Chi, Y., & Pienta, K. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.042671 · Cited by 567 · see citing works
Bell, D., Chomarat, P., Broyles, D., Netto, G., Harb, G. M., Lebecque, S., Valladeau, J., Davoust, J., Palucka, K. A., & Banchereau, J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.10.1417 · Cited by 544 · see citing works
Defining GM-CSF– and Macrophage-CSF–Dependent Macrophage Responses by In Vitro Models
Lacey, D. C., Achuthan, A. A., Fleetwood, A. J., Dinh, H., Roiniotis, J., Scholz, G. M., Chang, M. W., Beckman, S. K., Cook, A. D., & Hamilton, J. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103426 · Cited by 529 · see citing works
Obermajer, N., Muthuswamy, R., Lesnock, J. L., Edwards, R. P., & Kaliński, P. (2011) · Blood · doi:10.1182/blood-2011-07-365825 · Cited by 499 · see citing works
Duluc, D., Delneste, Y., Tan, F., Moles, M., Grimaud, L., Lenoir, J., Preisser, L., Anegón, I., Catala, L., Ifrah, N., et al. (2007) · Blood · doi:10.1182/blood-2007-02-072587 · Cited by 490 · see citing works
Obermajer, N., Muthuswamy, R., Odunsi, K. O., Edwards, R. P., & Kaliński, P. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2449 · Cited by 465 · see citing works
Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer
Nefedova, Y., Huang, M., Kusmartsev, S., Bhattacharya, R., Cheng, P., Salup, R., Jove, R., & Gabrilovich, D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.1.464 · Cited by 464 · see citing works
Gabrilovich, D. I., Ishida, T., Nadaf, S., Ohm, J. E., & Carbone, D. P. (1999) · PubMed · Cited by 459 · see citing works
Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6
Ratta, M., Fagnoni, F. F., Curti, A., Vescovini, R., Sansoni, P., Oliviero, B., Fogli, M., Ferri, E., della Cuna, G. R., Tura, S., et al. (2002) · Blood · doi:10.1182/blood.v100.1.230 · Cited by 442 · see citing works
Circulating interleukin‐6 predicts survival in patients with metastatic breast cancer
Salgado, R., Junius, S., Benoy, I. H., van Dam, P. A., Vermeulen, P., Marck, E. V., Huget, P., & Dirix, L. Y. (2002) · International Journal of Cancer · doi:10.1002/ijc.10833 · Cited by 435 · see citing works
Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers
Dieu‐Nosjean, M., Giraldo, N. A., Kaplon, H., Germain, C., Fridman, W. H., & Sautès‐Fridman, C. (2016) · Immunological Reviews · doi:10.1111/imr.12405 · Cited by 417 · see citing works
Dieu‐Nosjean, M., Massacrier, C., Homey, B., Vanbervliet, B., Pin, J., Vicari, A. P., Lebecque, S., Dezutter‐Dambuyant, C., Schmitt, D., Zlotnik, A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.705 · Cited by 378 · see citing works
Self-citationRemark, R., Alifano, M., Cremer, I., Mansuet‐Lupo, A., Dieu‐Nosjean, M., Riquet, M., Crozet, L., Ouakrim, H., Goc, J., Cazes, A., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3847 · Cited by 391 · see citing works
Transcriptional regulation of myeloid-derived suppressor cells
Condamine, T., Mastio, J., & Gabrilovich, D. I. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.4ri0515-204r · Cited by 368 · see citing works
Heusinkveld, M., van Steenwijk, P. J. D. V., Goedemans, R., Ramwadhdoebé, T. H., Gorter, A., Welters, M. J. P., van Hall, T., & van der Burg, S. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100889 · Cited by 368 · see citing works
Tumor-Associated Macrophages in Breast Cancer
Leek, R., & Harris, A. L. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1020304003704 · Cited by 353 · see citing works
Ben‐Baruch, A. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.07.006 · Cited by 336 · see citing works
Hartmann, E., Wollenberg, B., Rothenfußer, S., Wagner, M., Wellisch, D., Mack, B., Giese, T., Gires, O., Endres, S., & Hartmann, G. (2003) · PubMed · Cited by 335 · see citing works
Dendritic cell dysfunction in cancer: A mechanism for immunosuppression
Pinzón‐Charry, A., Maxwell, T., & López, J. A. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01371.x · Cited by 328 · see citing works
PD‐L1 expression on tolerogenic APCs is controlled by STAT‐3
Wölfle, S. J., Strebovsky, J., Bartz, H., Sähr, A., Arnold, C., Kaiser, C., Dalpke, A. H., & Heeg, K. M. (2010) · European Journal of Immunology · doi:10.1002/eji.201040979 · Cited by 325 · see citing works
Pan, P., Wang, G. X., Yin, B., Ozao, J. J., Ku, H. T., Divino, C. M., & Chen, S. (2007) · Blood · doi:10.1182/blood-2007-04-086835 · Cited by 319 · see citing works
Nefedova, Y., Nagaraj, S., Rosenbauer, A., Muro‐Cacho, C., Sebti, S. M., & Gabrilovich, D. I. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0529 · Cited by 318 · see citing works
Bachelot, T., Ray-Coquard, I., Ménétrier‐Caux, C., Rastkha, M., Duc, A., & Blay, J. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600956 · Cited by 317 · see citing works
Self-citationInflammatory cell infiltration of tumors: Jekyll or Hyde
Talmadge, J. E., Donkor, M. K., & Scholar, E. M. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9072-0 · Cited by 311 · see citing works
Active immunization against cancer with dendritic cells: The near future
Steinman, R. M., & Dhodapkar, M. V. (2001) · International Journal of Cancer · doi:10.1002/ijc.1503 · Cited by 299 · see citing works
Keilholz, U., Weber, J. S., Finke, J. H., Gabrilovich, D. I., Kast, W. M., Disis, M. L., Kirkwood, J. M., Scheibenbogen, C., Schlom, J., Maino, V. C., et al. (2002) · Journal of Immunotherapy · doi:10.1097/00002371-200203000-00001 · Cited by 298 · see citing works
Immature myeloid cells and cancer-associated immune suppression
Kusmartsev, S. A., & Gabrilovich, D. I. (2002) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-002-0280-8 · Cited by 297 · see citing works
Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species
Kusmartsev, S. A., & Gabrilovich, D. I. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0103010 · Cited by 292 · see citing works
The Macrophage Growth Factor CSF-1 in Mammary Gland Development and Tumor Progression
Lin, E. Y., Gouon–Evans, V., Nguyen, A., & Pollard, J. W. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1020399802795 · Cited by 292 · see citing works
Targeting STAT3 affects melanoma on multiple fronts
Kortylewski, M., Jove, R., & Yu, H. (2005) · Cancer and Metastasis Reviews · doi:10.1007/s10555-005-1580-1 · Cited by 282 · see citing works
Schreibelt, G., Tel, J., Sliepen, K., Benítez‐Ribas, D., Figdor, C. G., Adema, G. J., & de Vries, I. J. M. (2010) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-010-0833-1 · Cited by 270 · see citing works
Obesity and cancer: existing and new hypotheses for a causal connection
Stone, T. W., McPherson, M., & Gail Darlington, L. (2018) · eBioMedicine · doi:10.1016/j.ebiom.2018.02.022 · Cited by 262 · see citing works
Dendritic Cell-Based Xenoantigen Vaccination for Prostate Cancer Immunotherapy
Fong, L. H., Brockstedt, D. G., Benike, C. J., Breen, J. K., Strang, G., Ruegg, C. L., & Engleman, E. G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.7150 · Cited by 252 · see citing works
Altered maturation of peripheral blood dendritic cells in patients with breast cancer
Bella, S. D., Gennaro, M., Vaccari, M., Ferraris, C., Nicola, S., Riva, A., Clerici, M., Greco, M., & Villa, M. L. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601243 · Cited by 239 · see citing works
Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells
Kiertscher, S. M., Luo, J., Dubinett, S. M., & Roth, M. D. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.3.1269 · Cited by 238 · see citing works
Tumor cyclooxygenase 2-dependent suppression of dendritic cell function.
Sharma, S. P., Stolina, M., Yang, S.-C., Baratelli, F. E., Lin, J. F.-H., Atianzar, K., Luo, J., Zhu, L., Lin, Y., Huang, M., et al. (2003) · PubMed · Cited by 234 · see citing works
Regulatory T Cells in Ovarian Cancer: Biology and Therapeutic Potential
Barnett, B. G., Kryczek, I., Cheng, P. J., Zou, W., & Curiel, T. J. (2005) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2005.00330.x · Cited by 233 · see citing works
On the origin of myeloid-derived suppressor cells
Millrud, C. R., Bergenfelz, C., & Leandersson, K. (2016) · Oncotarget · doi:10.18632/oncotarget.12278 · Cited by 232 · see citing works
Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment
Kopfstein, L., & Christofori, G. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5296-8 · Cited by 230 · see citing works
Tumour escape from immune surveillance through dendritic cell inactivation
Vicari, A. P., Caux, C., & Trinchieri, G. (2002) · Seminars in Cancer Biology · doi:10.1006/scbi.2001.0400 · Cited by 229 · see citing works
Self-citationWang, Q., Ni, H., Lan, L., Wei, X., Xiang, R., & Wang, Y. (2010) · Cell Research · doi:10.1038/cr.2010.52 · Cited by 219 · see citing works
Kurth, I., Willimann, K., Schaerli, P., Hunziker, T., Clark‐Lewis, I., & Moser, B. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.855 · Cited by 216 · see citing works
Becht, É., Giraldo, N. A., Germain, C., de Reyniès, A., Laurent‐Puig, P., Zucman‐Rossi, J., Dieu‐Nosjean, M., Sautès‐Fridman, C., & Fridman, W. H. (2016) · Advances in immunology · doi:10.1016/bs.ai.2015.12.002 · Cited by 213 · see citing works
Interferon-γ switches monocyte differentiation from dendritic cells to macrophages
Delneste, Y., Charbonnier, P., Herbault, N., Magistrelli, G., Caron, G., Bonnefoy, J., & Jeannin, P. (2002) · Blood · doi:10.1182/blood-2002-04-1164 · Cited by 211 · see citing works
Myeloid‐derived suppressor cells in cancer: recent progress and prospects
Khaled, Y. S., Ammori, B. J., & Elkord, E. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.29 · Cited by 208 · see citing works
Farid, S. G., Aldouri, A., Morris‐Stiff, G. J., Khan, A. Z., Toogood, G. J., Lodge, J. P. A., & Prasad, R. K. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181bfda3c · Cited by 209 · see citing works
Sombroek, C. C., Stam, A. G. M., Masterson, A. J., Lougheed, S. M., Schakel, M. J. A. G., Meijer, C. J. L. M., Pinedo, H. M., van den Eertwegh, A. J. M., Scheper, R. J., & de Gruijl, T. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.9.4333 · Cited by 204 · see citing works
Péguet‐Navarro, J., Sportouch, M., Popa, I., Berthier‐Vergnes, O., Schmitt, D., & Portoukalian, J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.7.3488 · Cited by 203 · see citing works
Conway, B. R., O'Sullivan, E. D., Cairns, C., O’Sullivan, J., Simpson, D. J., Salzano, A., Connor, K. L., Ding, P., Humphries, D. C., Stewart, K., et al. (2020) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020060806 · Cited by 199 · see citing works
van Gisbergen, K. P. J. M., Aarnoudse, C. A., Meijer, G. A., Geijtenbeek, T. B. H., & van Kooyk, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4140 · Cited by 192 · see citing works
Balance of MafB and PU. 1 specifies alternative macrophage or dendritic cell fate
Bakri, Y., Sarrazin, S., Mayer, U. P., Tillmanns, S., Nerlov, C., Boned, A., & Sieweke, M. H. (2005) · Blood · doi:10.1182/blood-2004-04-1448 · Cited by 187 · see citing works
The fibroblast: Sentinel cell and local immune modulator in tumor tissue
Silzle, T., Randolph, G. J., Kreutz, M. P., & Kunz‐Schughart, L. A. (2003) · International Journal of Cancer · doi:10.1002/ijc.11542 · Cited by 185 · see citing works
Induction of potent antitumor immunity by in situ targeting of intratumoral DCs
Furumoto, K., Soares, L. R. B., Engleman, E. G., & Mérad, M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19762 · Cited by 206 · see citing works
Kusmartsev, S. A., & Gabrilovich, D. I. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9002-6 · Cited by 183 · see citing works
Induction of potent antitumor immunity by in situ targeting of intratumoral DCs
Furumoto, K., Soares, L., Engleman, E. G., & Merad, M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419762 · Cited by 180 · see citing works
Yañez, R., Oviedo, A., Aldea, M., Bueren, J. A., & Lamana, M. L. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.08.008 · Cited by 177 · see citing works
Négrier, S., Pérol, D., Ménétrier‐Caux, C., Escudier, B. J., Pallardy, M., Ravaud, A., Douillard, J., Chevreau, C., Lasset, C., & Blay, J. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.06.121 · Cited by 176 · see citing works
Self-citationChemokines and Dendritic Cell Traffic
Sozzani, S., Allavena, P., Vecchi, A., & Mantovani, A. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1006659211340 · Cited by 171 · see citing works
Pockaj, B. A., Basu, G. D., Pathangey, L. B., Gray, R. J., Hernández‐Davó, J. L., Gendler, S. J., & Mukherjee, P. (2004) · Annals of Surgical Oncology · doi:10.1245/aso.2004.05.027 · Cited by 168 · see citing works
Dendritic Cells and Tumor Microenvironment: A Dangerous Liaison
Fricke, I., & Gabrilovich, D. I. (2006) · Immunological Investigations · doi:10.1080/08820130600803429 · Cited by 165 · see citing works
Tumor-derived factors modulating dendritic cell function
Zong, J., Keskinov, A. A., Shurin, G. V., & Shurin, M. R. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1820-y · Cited by 165 · see citing works
Bear, A. S., Kennedy, L. C., Young, J. K., Perna, S. K., Almeida, J. P. M., Lin, A. Y., Eckels, P. C., Drezek, R. A., & Foster, A. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069073 · Cited by 164 · see citing works
Shurin, M. R., Shurin, G. V., Lokshin, A. E., Yurkovetsky, Z. R., Gutkin, D. W., Chatta, G. S., Zhong, H., Han, B., & Ferris, R. L. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9010-6 · Cited by 162 · see citing works
Shinriki, S., Jono, H., Ota, K., Ueda, M., Kudo, M., Ota, T., Oike, Y., Endo, M., Ibusuki, M., Hiraki, A., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0287 · Cited by 163 · see citing works
Bharadwaj, U., Li, M., Zhang, R., Chen, C., & Yao, Q. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3963 · Cited by 160 · see citing works
Dendritic cells: Immunological sentinels with a central role in health and disease
Stockwin, L. H., McGonagle, D., Martin, I. G., & Blair, G. E. (2000) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2000.00888.x · Cited by 156 · see citing works
Antitumor Effects of the Mouse Chemokine 6Ckine/SLC Through Angiostatic and Immunological Mechanisms
Vicari, A. P., Aït‐Yahia, S., Chemin, K., Müeller, A., Zlotnik, A., & Caux, C. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.1992 · Cited by 153 · see citing works
Self-citationHegde, S., Pahne, J., & Smola, S. (2004) · The FASEB Journal · doi:10.1096/fj.03-0969fje · Cited by 152 · see citing works
Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease
O’Connor, P. M. J., Lapointe, T. K., Beck, P. L., & Buret, A. G. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21217 · Cited by 151 · see citing works
Manuel, M., Trédan, O., Bachelot, T., Clapisson, G., Courtier, A., Parmentier, G., Rabeony, T., Grivès, A., Perez, S., Mouret, J.-F., et al. (2012) · OncoImmunology · doi:10.4161/onci.19545 · Cited by 150 · see citing works
Self-citationDomínguez‐Soto, Á., Sierra‐Filardi, E., Puig‐Kröger, A., Pérez-Maceda, B. T., Gómez, F., Corcuera, M. T., Sánchez‐Mateos, P., & Corbí, A. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000475 · Cited by 147 · see citing works
Orsini, E., Guarini, A. R., Chiaretti, S., Mauro, F. R., & Foà, R. (2003) · PubMed · Cited by 148 · see citing works
Chang, C.-C. J., Wright, A., & Punnonen, J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3584 · Cited by 146 · see citing works
PGE2-Driven Induction and Maintenance of Cancer-Associated Myeloid-Derived Suppressor Cells
Obermajer, N., Wong, J. L., Edwards, R. P., Odunsi, K. O., Moysich, K. B., & Kaliński, P. (2012) · Immunological Investigations · doi:10.3109/08820139.2012.695417 · Cited by 144 · see citing works
Garcia, A. J., Ruscetti, M. A., Arenzana, T. L., Tran, L. M., Bianchi-Frias, D., Sybert, E., Priceman, S. J., Wu, L., Nelson, P. S., Smale, S. T., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00090-14 · Cited by 143 · see citing works
- Authors
- Menetrier-Caux, C., Montmain, G., Dieu, M. C., Bain, C., Favrot, M. C., Caux, C., & Blay, J. Y.
- Affiliations
- From Unité Cytokine et Cancer, Unité INSERM 453, Centre Léon Bérard, Lyon, France; and Schering Plough, Dardilly, France.
- Inserm (FR)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1998-12-15
- Volume
- 92
- Issue
- 12
- Pages
- 4778-4791
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W193748226
- Cited by
- 590
- References
- 48
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 20 · 2019: 16 · 2018: 13 · 2017: 9 · 2016: 25 · 2015: 26 · 2014: 19 · 2013: 30 · 2012: 25
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- dendritic cell differentiation, CD34+ progenitors, renal cell carcinoma, tumor immune evasion, interleukin-6, macrophage colony-stimulating factor, M-CSF receptor, GM-CSF receptor, antigen-presenting cells, monocyte differentiation, CD1a, CD14, soluble factors
- MeSH terms
- Antibodies, Carcinoma, Renal Cell, Cell Differentiation, Cell Division, Dendritic Cells, Dose-Response Relationship, Drug, Gene Expression Regulation, Humans, Lymphokines, Tumor Cells, Cultured, Interleukin-6, Immunophenotyping, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Endothelial Growth Factors, Culture Media, Conditioned, Antigens, CD34, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Cell Size
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