The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Human β‐defensin 3 has immunosuppressive activity in vitro and in vivo
Open accessAbstract
β‐defensins are antimicrobial peptides with an essential role in the innate immune response. In addition β‐defensins can also chemoattract cells involved in adaptive immunity. Until now, based on evidence from dendritic cell stimulation, human β defensin‐3 (hBD3) was considered pro‐inflammatory. We present evidence here that hBD3 lacks pro‐inflammatory activity in human and mouse primary Mϕ. In addition, in the presence of LPS, hBD3 and the murine orthologue Defb14 (but not hBD2), effectively inhibit TNF‐α and IL‐6 accumulation implying an anti‐inflammatory function. hBD3 also inhibits CD40/IFN‐γ stimulation of Mϕ and in vivo, hBD3 significantly reduces the LPS‐induced TNF‐α level in serum. Recent work has revealed that hBD3 binds melanocortin receptors but we provide evidence that these are not involved in hBD3 immunomodulatory activity. This implies a dual role for hBD3 in antimicrobial activity and resolution of inflammation.
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Cites
Interleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
Molecular and Evolutionary History of Melanism in North American Gray Wolves
Anderson, T. M., vonHoldt, B. M., Candille, S. I., Musiani, M., Greco, C., Stahler, D. R., Smith, D. W., Padhukasahasram, B., Randi, E., Leonard, J. A., et al. (2009) · Science · doi:10.1126/science.1165448 · Cited by 416
Cited by
Antimicrobial host defence peptides: functions and clinical potential
Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0058-8 · Cited by 1,502
Self-citationGeng, L. N., Yao, Z., Snider, L., Fong, A. P., Cech, J. N., Young, J. M., van der Maarel, S. M., Ruzzo, W. L., Gentleman, R. C., Tawil, R., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.013 · Cited by 458
Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation
Versey, Z., da Cruz Nizer, W. S., Russell, E., Zigic, S., DeZeeuw, K. G., Marek, J. E., Overhage, J., & Cassol, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.648554 · Cited by 253
Metadata
- Authors
- Semple, F., Webb, S., Li, H., Patel, H. B., Perretti, M., Jackson, I. J., Gray, M., Davidson, D. J., & Dorin, J. R.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2010-04
- Volume
- 40
- Issue
- 4
- Pages
- 1073-1078
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2129141151
- Cited by
- 184
- References
- 3
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Semple, F., Webb, S., Li, H., Patel, H. B., Perretti, M., Jackson, I. J., Gray, M., Davidson, D. J., & Dorin, J. R. (2010). Human β‐defensin 3 has immunosuppressive activity in vitro and in vivo. European Journal of Immunology. https://doi.org/10.1002/eji.200940041
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