The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome
Open accessAbstract
The inflammasome pathway functions to regulate caspase‐1 activation in response to a broad range of stimuli. Caspase‐1 activation is required for the maturation of the pivotal pro‐inflammatory cytokines of the pro‐IL‐1β family. In addition, caspase‐1 activation leads to a certain type of cell death known as pyroptosis. Activation of the inflammasome has been shown to play a critical role in the recognition and containment of various microbial pathogens, including the intracellularly replicating Listeria monocytogenes; however, the inflammasome pathways activated during L. monocytogenes infection are only poorly defined. Here, we demonstrate that L. monocytogenes activates both the NLRP3 and the AIM2 inflammasome, with a predominant involvement of the AIM2 inflammasome. In addition, L. monocytogenes‐triggered cell death was diminished in the absence of both AIM2 and NLRP3, and is concomitant with increased intracellular replication of L. monocytogenes. Altogether, these data establish a role for DNA sensing through the AIM2 inflammasome in the detection of intracellularly replicating bacteria.
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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Immunological and inflammatory functions of the interleukin-1 family
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Cryopyrin activates the inflammasome in response to toxins and ATP
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Self-citationDAMPs, PAMPs and alarmins: all we need to know about danger
Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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Self-citationThe NALP3 inflammasome is involved in the innate immune response to amyloid-β
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Cited by
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
Miao, E. A., Leaf, I. A., Treuting, P. M., Mao, D. P., Dors, M., Sarkar, A., Warren, S. E., Wewers, M. D., & Aderem, A. (2010) · Nature Immunology · doi:10.1038/ni.1960 · Cited by 1,336
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GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals
Shenoy, A. R., Wellington, D. A., Kumar, P., Kassa, H., Booth, C. J., Cresswell, P., & MacMicking, J. D. (2012) · Science · doi:10.1126/science.1217141 · Cited by 522
Pathogenesis and Pathophysiology of Pneumococcal Meningitis
Mook-Kanamori, B. B., Geldhoff, M., van der Poll, T., & van de Beek, D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-11 · Cited by 492
A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases
Barnett, K. C., Li, S., Liang, K., & Ting, J. P.-Y. (2023) · Cell · doi:10.1016/j.cell.2023.04.025 · Cited by 458
Metadata
- Authors
- Kim, S., Bauernfeind, F., Ablasser, A., Hartmann, G., Fitzgerald, K. A., Latz, E., & Hornung, V.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2010-06
- Volume
- 40
- Issue
- 6
- Pages
- 1545-1551
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2103200355
- Cited by
- 255
- References
- 12
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kim, S., Bauernfeind, F., Ablasser, A., Hartmann, G., Fitzgerald, K. A., Latz, E., & Hornung, V. (2010). Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome. European Journal of Immunology. https://doi.org/10.1002/eji.201040425
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