IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works

The Inflammasomes

Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627 · see citing works

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831 · see citing works

IFI16 is an innate immune sensor for intracellular DNA

Unterholzner, L., Keating, S. E., Baran, M., Horan, K. A., Jensen, S. B., Sharma, S., Sirois, C. M., Jin, T., Latz, E., Xiao, T. S., et al. (2010) · Nature Immunology · doi:10.1038/ni.1932 · Cited by 1,643 · see citing works

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Rathinam, V. A. K., Jiang, Z., Waggoner, S. N., Sharma, S., Cole, L. E., Waggoner, L., Vanaja, S. K., Monks, B. G., Ganesan, S., Latz, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1864 · Cited by 1,331 · see citing works

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221 · see citing works

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Bürckstümmer, T., Baumann, C., Blüml, S., Dixit, E., Dürnberger, G., Jahn, H., Planyavsky, M., Bilban, M., Colinge, J., Bennett, K. L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1702 · Cited by 1,091 · see citing works

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

Muruve, D. A., Pétrilli, V., Zaiss, A. K., White, L. R., Clark, S. A., Ross, P. J., Parks, R. J., & Tschopp, J. (2008) · Nature · doi:10.1038/nature06664 · Cited by 936 · see citing works

Kaposi's Sarcoma-Associated Herpesvirus

Boshoff, C., & Weiss, R. A. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60739-3 · Cited by 398 · see citing works

A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

Hsu, L.-C., Ali, S. R., McGillivray, S. M., Tseng, P., Mariathasan, S., Humke, E. W., Eckmann, L., Powell, J. J., Nizet, V., Dixit, V. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802726105 · Cited by 388 · see citing works

Concurrent Expression of Latent and a Limited Number of Lytic Genes with Immune Modulation and Antiapoptotic Function by Kaposi's Sarcoma-Associated Herpesvirus Early during Infection of Primary Endothelial and Fibroblast Cells and Subsequent Decline of Lytic Gene Expression

Krishnan, H. H., Naranatt, P. P., Smith, M. S., Zeng, L., Bloomer, C., & Chandran, B. (2004) · Journal of Virology · doi:10.1128/jvi.78.7.3601-3620.2004 · Cited by 314 · see citing works

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

Bryan, N. B., Dorfleutner, A., Rojanasakul, Y., & Stehlik, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802367 · Cited by 260 · see citing works

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

Kim-Hellmuth, S., Bauernfeind, F. G., Ablasser, A., Hartmann, G., Fitzgerald, K. A., Latz, E., & Hornung, V. (2010) · European Journal of Immunology · doi:10.1002/eji.201040425 · Cited by 255 · see citing works

Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

Gregory, S. M., Davis, B. K., West, J. A., Taxman, D. J., Matsuzawa, S.-I., Reed, J. C., Ting, J. P. ‐., & Damania, B. (2011) · Science · doi:10.1126/science.1199478 · Cited by 217 · see citing works

Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila

Case, C. L., Shin, S., & Roy, C. R. (2009) · Infection and Immunity · doi:10.1128/iai.01382-08 · Cited by 176 · see citing works

ERK1/2 and MEK1/2 Induced by Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Early during Infection of Target Cells Are Essential for Expression of Viral Genes and for Establishment of Infection

Sharma-Walia, N., Krishnan, H. H., Naranatt, P. P., Zeng, L., Smith, M. S., & Chandran, B. (2005) · Journal of Virology · doi:10.1128/jvi.79.16.10308-10329.2005 · Cited by 171 · see citing works

Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome

Schroder, K., Muruve, D. A., & Tschopp, J. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.011 · Cited by 143 · see citing works

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

Aglipay, J. A., Lee, S. W., Okada, S., Fujiuchi, N., Ohtsuka, T., Kwak, J. C., Wang, Y., Johnstone, R. W., Deng, C., Qin, J., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1207057 · Cited by 129 · see citing works

Kaposi's Sarcoma Associated Herpes Virus (KSHV) Induced COX-2: A Key Factor in Latency, Inflammation, Angiogenesis, Cell Survival and Invasion

Sharma-Walia, N., Paul, A. G., Bottero, V., Sadagopan, S., Veettil, M. V., Kerur, N., & Chandran, B. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000777 · Cited by 121 · see citing works

Inflammatory cytokines induce endothelial cells to produce and release basic fibroblast growth factor and to promote Kaposi's sarcoma-like lesions in nude mice

Samaniego, F., Markham, P. D., Gendelman, R., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1887 · Cited by 118 · see citing works

Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes

Bryan, N. B., Dorfleutner, A., Kramer, S. J., Yun, C., Rojanasakul, Y., & Stehlik, C. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-23 · Cited by 117 · see citing works

Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase

Schwartz, R. A., Carson, C. T., Schuberth, C., & Weitzman, M. D. (2009) · Journal of Virology · doi:10.1128/jvi.00318-09 · Cited by 115 · see citing works

Viral Oncogene–Induced DNA Damage Response Is Activated in Kaposi Sarcoma Tumorigenesis

Koopal, S., Furuhjelm, J., Järviluoma, A., Jäämaa, S., Pyakurel, P., Pussinen, C., Wirzenius, M., Biberfeld, P., Alitalo, K. K., Laiho, M., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030140 · Cited by 108 · see citing works

Interactions of viruses with the cellular DNA repair machinery

Weitzman, M. D., Carson, C. T., Schwartz, R. A., & Lilley, C. E. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.018 · Cited by 104 · see citing works

Requirement of IFI16 for the Maximal Activation of p53 Induced by Ionizing Radiation

Fujiuchi, N., Aglipay, J. A., Ohtsuka, T., Maehara, N., Sahin, F., Su, G. H., Lee, S. W., & Ouchi, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400344200 · Cited by 102 · see citing works

Kaposi's Sarcoma-Associated Herpesvirus Induces Sustained NF-κB Activation during De Novo Infection of Primary Human Dermal Microvascular Endothelial Cells That Is Essential for Viral Gene Expression

Sadagopan, S., Sharma-Walia, N., Veettil, M. V., Raghu, H., Ramu, S., Bottero, V., & Chandran, B. (2007) · Journal of Virology · doi:10.1128/jvi.02333-06 · Cited by 96 · see citing works

Kaposi's Sarcoma?Associated Herpesvirus

Moore, P. S., & Chang, Y. (2009) · doi:10.1128/9781555815981.ch25 · Cited by 77 · see citing works

Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): Role of heparan sulfate, DC-SIGN, integrins and signaling

Kerur, N., Veettil, M. V., Sharma-Walia, N., Sadagopan, S., Bottero, V., Paul, A. G., & Chandran, B. (2010) · Virology · doi:10.1016/j.virol.2010.07.012 · Cited by 73 · see citing works

Comprehensive Studies on Subcellular Localizations and Cell Death-Inducing Activities of Eight GFP-Tagged Apoptosis-Related Caspases

Shikama, Y., Mami, U., Miyashita, T., et al. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5153 · Cited by 71 · see citing works

Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing

Costa, S., Borgogna, C., Mondini, M., Andrea, M. D., Meroni, P. L., Berti, E., Gariglio, M., & Landolfo, S. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10097.x · Cited by 65 · see citing works

Interleukin 1β induces expression of human herpesvirus 8 encoded genes in BCBL-1 cells

Yu, Y., Roan, F., & Offermann, M. K. (1999) · AIDS · doi:10.1097/00002030-199910220-00028 · Cited by 3 · see citing works

Kaposi’s Sarcoma Associated Herpes Virus

Bibi, M., & Masood, N. (2024) · Springer eBooks · doi:10.1007/978-981-97-6948-3_8 · Cited by 2 · see citing works

The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation

Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133328 · Cited by 3,539 · see citing works

Inflammasomes in health and disease

Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works

Pyroptotic cell death defends against intracellular pathogens

Jorgensen, I., & Miao, E. A. (2015) · Immunological Reviews · doi:10.1111/imr.12287 · Cited by 1,021 · see citing works

Initiation and perpetuation of <scp>NLRP</scp> 3 inflammasome activation and assembly

Elliott, E. I., & Sutterwala, F. S. (2015) · Immunological Reviews · doi:10.1111/imr.12286 · Cited by 821 · see citing works

Mechanism of NLRP3 inflammasome activation

Sutterwala, F. S., Haasken, S., & Cassel, S. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12458 · Cited by 736 · see citing works

Untitled work

Lee (2019) · doi:10.1038/s12276-019-0299-y · Cited by 635 · see citing works

Functions of ROS in Macrophages and Antimicrobial Immunity

Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

Monroe, K. M., Yang, Z., Johnson, J. R., Geng, X., Doitsh, G., Krogan, N. J., & Greene, W. C. (2014) · Science · doi:10.1126/science.1243640 · Cited by 511 · see citing works

Mechanisms of inflammasome activation: recent advances and novel insights

Vanaja, S. K., Rathinam, V. A. K., & Fitzgerald, K. A. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.12.009 · Cited by 499 · see citing works

STING and the innate immune response to nucleic acids in the cytosol

Burdette, D. L., & Vance, R. E. (2013) · Nature Immunology · doi:10.1038/ni.2491 · Cited by 501 · see citing works

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

Orzalli, M. H., DeLuca, N. A., & Knipe, D. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211302109 · Cited by 422 · see citing works

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

Jakobsen, M. R., Bak, R. O., Andersen, A., Berg, R. K., Jensen, S. B., Jin, T., Laustsen, A., Hansen, K., Østergaard, L., Fitzgerald, K. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311669110 · Cited by 344 · see citing works

Mitochondria, Oxidative Stress and Innate Immunity

Chen, Y., Zhou, Z., & Min, W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01487 · Cited by 315 · see citing works

Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16

Li, T., Diner, B. A., Chen, J., & Cristea, I. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203447109 · Cited by 297 · see citing works

Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes

Johnson, K. E., Chikoti, L., & Chandran, B. (2013) · Journal of Virology · doi:10.1128/jvi.00082-13 · Cited by 271 · see citing works

Cytosolic DNA Sensing in Organismal Tumor Control

Vanpouille-Box, C., Demaria, S., Formenti, S. C., & Galluzzi, L. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.05.013 · Cited by 250 · see citing works

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

Gariano, G. R., Dell'Oste, V., Bronzini, M., Gatti, D., Luganini, A., De Andrea, M., Gribaudo, G., Gariglio, M., & Landolfo, S. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002498 · Cited by 227 · see citing works

Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion

Li, T., Chen, J., & Cristea, I. M. (2013) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2013.10.007 · Cited by 226 · see citing works

Inflammasomes: sensors of metabolic stresses for vascular inflammation

Yang, X.-F. (2013) · Frontiers in Bioscience · doi:10.2741/4127 · Cited by 134 · see citing works

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

Lan, Y. Y., Heather, J. M., Eisenhaure, T., Garris, C. S., Lieb, D., Raychowdhury, R., & Hacohen, N. (2019) · Aging Cell · doi:10.1111/acel.12901 · Cited by 130 · see citing works

Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity

Zahid, A., Ismail, H., Li, B., & Jin, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.613039 · Cited by 100 · see citing works

The Viral Ubiquitin Ligase ICP0 Is neither Sufficient nor Necessary for Degradation of the Cellular DNA Sensor IFI16 during Herpes Simplex Virus 1 Infection

Cuchet-Lourenço, D., Anderson, G., Sloan, E., Orr, A., & Everett, R. D. (2013) · Journal of Virology · doi:10.1128/jvi.02474-13 · Cited by 98 · see citing works

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression

Diner, B. A., Lum, K. K., Javitt, A., & Cristea, I. M. (2015) · Molecular &amp; Cellular Proteomics · doi:10.1074/mcp.m114.047068 · Cited by 93 · see citing works

IFI16: At the Interphase between Innate DNA Sensing and Genome Regulation

Jakobsen, M. R., & Paludan, S. R. (2014) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.06.004 · Cited by 72 · see citing works

The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology

Greco, T. M., Diner, B. A., & Cristea, I. M. (2014) · Annual Review of Virology · doi:10.1146/annurev-virology-031413-085527 · Cited by 67 · see citing works

Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense

Guise, A., Budayeva, H., Diner, B., & Cristea, I. (2013) · Viruses · doi:10.3390/v5071607 · Cited by 43 · see citing works

Molecular mechanisms regulating NLRP3 inflammasome activation

Eun-Kyeong, Jo, Jin, et al. (2016) · 中国免疫学杂志：英文版 · Cited by 2 · see citing works

The inflammasome as future therapeutic target: Development of inflammasome challenge tests

Dillingh, M. R. (2014) · Journal of Clinical & Cellular Immunology

NLRP3 licenses NLRP11 for inflammasome activation in human macrophages

Gangopadhyay, A., Devi, S., Tenguria, S., Carrière, J., Nguyen, H., Jäger, E., Khatri, H., Chu, L. H., Ratsimandresy, R. A., Dorfleutner, A., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01220-3 · Cited by 61 · see citing works

CARD-only proteins (COPs) inhibit uric acid crystal-induced inflammasome activation and ameliorate gout

Devi, S., Indramohan, M., Jäger, E., Carrière, J., Chu, L. H., Almeida, L., Greaves, D. R., Stehlik, C., & Dorfleutner, A. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.210.supp.167.16

Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome

Zhang, T., Ding, S., & Wang, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910866 · Cited by 51 · see citing works