The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals
Open accessAbstract
Generating Inflammasomes: Inflammasomes are large, multiprotein complexes that assemble in response to infection that are also involved in the pathogenesis of a variety of other diseases, including type 2 diabetes and atherosclerosis. The assembly of the inflammasome triggers an inflammatory cascade that results in the activation of caspase-1 and production of the cytokines interleukin-1 and -18. Very little, however, is known about the specific signals that trigger inflammasome assembly. Shenoy et al. (p. 481, published online 29 March; see the Perspective by Caffrey and Fitzgerald ) now show that guanylate binding protein 5 (GBP5) promotes the assembly of the NLRP3-containing inflammasome in response to certain activation signals, such as pathogenic bacteria and adenosine triphosphate, but not others, like crystalline stimuli. Mice deficient in GBP5 exhibited impaired caspase-1 activation and production of cytokines. NLRP3 inflammasome–dependent responses to pathogenic bacteria and inflammatory stimuli were also impaired in mice lacking GBP5.
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Cited by
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
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Inflammasomes: mechanism of assembly, regulation and signalling
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Activation and regulation of the inflammasomes
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Mechanism and Regulation of NLRP3 Inflammasome Activation
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Molecular mechanisms regulating NLRP3 inflammasome activation
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Metadata
- Authors
- Shenoy, A. R., Wellington, D. A., Kumar, P., Kassa, H., Booth, C. J., Cresswell, P., & MacMicking, J. D.
- Venue
- Science
- Published
- 2012-04-27
- Volume
- 336
- Issue
- 6080
- Pages
- 481-485
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064456932
- Cited by
- 522
- References
- 38
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shenoy, A. R., Wellington, D. A., Kumar, P., Kassa, H., Booth, C. J., Cresswell, P., & MacMicking, J. D. (2012). GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals. Science. https://doi.org/10.1126/science.1217141
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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