Role of dectin-2 for host defense against systemic infection with Candida glabrata
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Although Candida glabrata is an important pathogenic Candida species, relatively little is known about its innate immune recognition. Here, we explore the potential role of Dectin-2 for host defense against C. glabrata. Dectin-2-deficient (Dectin-2(-/-)) mice were found to be more susceptible to C. glabrata infections, showing a defective fungal clearance in kidneys but not in the liver. The increased susceptibility to infection was accompanied by lower production of T helper 1 (Th1) and Th17-derived cytokines by splenocytes of Dectin-2(-/-) mice, while macrophage-derived cytokines were less affected. These defects were associated with a moderate yet significant decrease in phagocytosis of the fungus by the Dectin-2(-/-) macrophages and neutrophils. Neutrophils of Dectin-2(-/-) mice also displayed lower production of reactive oxygen species (ROS) upon challenge with opsonized C. glabrata or C. albicans. This study suggests that Dectin-2 is important in host defense against C. glabrata and provides new insights into the host defense mechanisms against this important fungal pathogen.
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Neutrophils of dectin-2-/- knockout mice mount a deficient oxidative burst.
“However, neutrophils of the dectin-2-/- knock out mice, which displayed elevated susceptibility to C. glabrata infections, have been reported to mount a deficient oxidative burst, pointing towards a role of the dectin-2 receptor and neutrophils in the control of C. glabrata infections [144].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [144]
Neutrophils of dectin-2-/- knockout mice displayed elevated susceptibility to C. glabrata infections.
“However, neutrophils of the dectin-2-/- knock out mice, which displayed elevated susceptibility to C. glabrata infections, have been reported to mount a deficient oxidative burst, pointing towards a role of the dectin-2 receptor and neutrophils in the control of C. glabrata infections [144].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [144]
The C-type lectin receptors dectin 1 and dectin-2 have been implicated in the recognition of C. glabrata.
“Among the pathogen recognition receptors, the C-type lectin receptors, dectin 1 and dectin-2, which recognize cell wall β-glucan, and α-mannan and β-glucan, respectively, have been implicated in the recognition of C. glabrata [144,148].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [144]
The dectin-2 receptor and neutrophils play a role in the control of C. glabrata infections.
“However, neutrophils of the dectin-2-/- knock out mice, which displayed elevated susceptibility to C. glabrata infections, have been reported to mount a deficient oxidative burst, pointing towards a role of the dectin-2 receptor and neutrophils in the control of C. glabrata infections [144].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [144]
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Host immune responses to fungal infection
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- Authors
- Ifrim, D. C., Bain, J. M., Reid, D. M., Oosting, M., Verschueren, I., Gow, N. A. R., van Krieken, J. H., Brown, G. D., Kullberg, B.-J., Joosten, L. A. B., van der Meer, J. W. M., Koentgen, F., Erwig, L. P., Quintin, J., & Netea, M. G.
- Affiliations
- Radboud University Medical Center (NL)
- University of Aberdeen (GB)
- Radboud University Medical Center, Department of Pathology, Nijmegen, The Netherlands
- Radboud University Medical Center, Department of Internal Medicine, Division of Experimental Internal Medicine, Nijmegen, The Netherlands
- Ozgene Pty Ltd., Bentley, Australia
- Corresponding author
- Netea, Mihai G.
- ORCID
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2014-03
- Volume
- 82
- Issue
- 3
- Pages
- 1064-1073
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC3957982
- OpenAlex
- W2026106645
- Cited by
- 117
- References
- 46
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 6 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 12 · 2015: 11 · 2014: 7
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Infection and Immunity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- HAL (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (086558, 097377/Z/11/Z, 086827, 097377, 101873, 094847, 089930, 080088, 075470, 102705, 102705/Z/13/Z)
- European Commission (FP7/2007, 260338)
- University of Aberdeen
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- Dectin-2, Candida glabrata, innate immune recognition, host defense against fungi, Th1 cytokines, Th17 cytokines, macrophage phagocytosis, neutrophils, reactive oxygen species, Candida albicans, systemic fungal infection
- MeSH terms
- Animals, Candida albicans, Candidiasis, Female, Macrophages, Mice, Inbred C57BL, Neutrophils, Phagocytosis, Cytokines, Reactive Oxygen Species, Th1 Cells, Lectins, C-Type, Candida glabrata, Mice
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