Cited by 117Antifungal resistance and susceptibilityImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Role of dectin-2 for host defense against systemic infection with Candida glabrata

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Ifrim, Daniela C., Bain, Judith M., Reid, Delyth M., Oosting, Marije, Verschueren, Ineke, Gow, Neil A. R., van Krieken, J. Han, Brown, Gordon D. +7 more·2014·Infection and Immunity

Abstract

Although Candida glabrata is an important pathogenic Candida species, relatively little is known about its innate immune recognition. Here, we explore the potential role of Dectin-2 for host defense against C. glabrata. Dectin-2-deficient (Dectin-2(-/-)) mice were found to be more susceptible to C. glabrata infections, showing a defective fungal clearance in kidneys but not in the liver. The increased susceptibility to infection was accompanied by lower production of T helper 1 (Th1) and Th17-derived cytokines by splenocytes of Dectin-2(-/-) mice, while macrophage-derived cytokines were less affected. These defects were associated with a moderate yet significant decrease in phagocytosis of the fungus by the Dectin-2(-/-) macrophages and neutrophils. Neutrophils of Dectin-2(-/-) mice also displayed lower production of reactive oxygen species (ROS) upon challenge with opsonized C. glabrata or C. albicans. This study suggests that Dectin-2 is important in host defense against C. glabrata and provides new insights into the host defense mechanisms against this important fungal pathogen.

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Crossref · 10.1128/iai.01189-13

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  • Neutrophils of dectin-2-/- knockout mice mount a deficient oxidative burst.

    “However, neutrophils of the dectin-2-/- knock out mice, which displayed elevated susceptibility to C. glabrata infections, have been reported to mount a deficient oxidative burst, pointing towards a role of the dectin-2 receptor and neutrophils in the control of C. glabrata infections [144].”

    From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [144]

  • Neutrophils of dectin-2-/- knockout mice displayed elevated susceptibility to C. glabrata infections.

    “However, neutrophils of the dectin-2-/- knock out mice, which displayed elevated susceptibility to C. glabrata infections, have been reported to mount a deficient oxidative burst, pointing towards a role of the dectin-2 receptor and neutrophils in the control of C. glabrata infections [144].”

    From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [144]

  • The C-type lectin receptors dectin 1 and dectin-2 have been implicated in the recognition of C. glabrata.

    “Among the pathogen recognition receptors, the C-type lectin receptors, dectin 1 and dectin-2, which recognize cell wall β-glucan, and α-mannan and β-glucan, respectively, have been implicated in the recognition of C. glabrata [144,148].”

    From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [144]

  • The dectin-2 receptor and neutrophils play a role in the control of C. glabrata infections.

    “However, neutrophils of the dectin-2-/- knock out mice, which displayed elevated susceptibility to C. glabrata infections, have been reported to mount a deficient oxidative burst, pointing towards a role of the dectin-2 receptor and neutrophils in the control of C. glabrata infections [144].”

    From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [144]

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Authors
Ifrim, D. C., Bain, J. M., Reid, D. M., Oosting, M., Verschueren, I., Gow, N. A. R., van Krieken, J. H., Brown, G. D., Kullberg, B.-J., Joosten, L. A. B., van der Meer, J. W. M., Koentgen, F., Erwig, L. P., Quintin, J., & Netea, M. G.
Affiliations
  • Radboud University Medical Center (NL)
  • University of Aberdeen (GB)
  • Radboud University Medical Center, Department of Pathology, Nijmegen, The Netherlands
  • Radboud University Medical Center, Department of Internal Medicine, Division of Experimental Internal Medicine, Nijmegen, The Netherlands
  • Ozgene Pty Ltd., Bentley, Australia
Corresponding author
Netea, Mihai G.
Venue
Infection and Immunity
Published
2014-03
Volume
82
Issue
3
Pages
1064-1073
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
OpenAlex
W2026106645
Cited by
117
References
46
Citations by year
2026: 6 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 6 · 2019: 10 · 2018: 13 · 2017: 18 · 2016: 12 · 2015: 11 · 2014: 7
FWCI
7.26
Type
journal article
Language
en
Open access
Locations
  • Infection and Immunity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • HAL (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders
  • Wellcome Trust (086558, 097377/Z/11/Z, 086827, 097377, 101873, 094847, 089930, 080088, 075470, 102705, 102705/Z/13/Z)
  • European Commission (FP7/2007, 260338)
  • University of Aberdeen
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
Dectin-2, Candida glabrata, innate immune recognition, host defense against fungi, Th1 cytokines, Th17 cytokines, macrophage phagocytosis, neutrophils, reactive oxygen species, Candida albicans, systemic fungal infection
MeSH terms
Animals, Candida albicans, Candidiasis, Female, Macrophages, Mice, Inbred C57BL, Neutrophils, Phagocytosis, Cytokines, Reactive Oxygen Species, Th1 Cells, Lectins, C-Type, Candida glabrata, Mice

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