Coordinated expansion of both memory T cells and NK cells in response to CMV infection in humans
Open accessAbstract
NK cells are key players in the fight against persistent viruses. Human cytomegalovirus (HCMV) infection is associated with the presence of a population of CD16+ CD56 dim NKG2C+ NK cells in both acutely and latently infected individuals. Here, we studied the nature of these terminally differentiated NK cells in different human populations infected with HCMV: healthy donors stratified by age, thymectomized individuals, pregnant women suffering from primary CMV infection, and lung transplant patients. Both CD16+ CD56 dim NK‐ and CD8 T‐cell phenotypes as well as functional capacities were determined and stratified according to age and/or CMV event. Similarly to T‐cell responsiveness, we observe an accumulation over time of NKG2C+ NK cells, which preferentially expressed CD57. This accumulation is particularly prominent in elderly and amplified further by CMV infection. Latent HCMV infection (without replication) is sufficient for NKG2C+ CD57+ NK cells to persist in healthy individuals but is not necessarily required in old age. Collectively, the present work supports the emerging concept that CMV shapes both innate and adaptive immunity in humans.
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A decrease in NKG2A expression occurs from young to elderly adults.
“A decrease in NKG2A expression occurs from young to elderly adults [104, 105].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [105]
Unusual clonal expansion of NKG2C+CD57+ NK cells has been found in elderly CMV-seronegative donors, indicating that parameters related to aging other than CMV could influence the peripheral repertoire.
“this unusual clonal expansion of NKG2C+CD57+ NK cells has been found in elderly CMV-seronegative donors, indicating that parameters related to aging other than CMV could influence the peripheral repertoire [105].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [105]
CMV infection could be a parameter associated with expansion of long-lived memory-like NK cells characterized by CD94/NKG2C and CD57 expression.
“Recent evidence has demonstrated that CMV infection could be a parameter associated with this expansion of long-lived ‘memory-like’ NK cells, which are characterized by the expression of CD94/NKG2C and CD57 [105, 109].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [105]
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NKG2Cpos NK Cells Regulate the Expansion of Cytomegalovirus-Specific CD8 T Cells
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Enrichment of Cytomegalovirus-induced NKG2C+ Natural Killer Cells in the Lung Allograft
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Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood
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CD94 + natural killer cells potentiate pulmonary ischaemia–reperfusion injury
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Obtaining Gene-Modified HLA-E-Expressing Feeder Cells for Stimulation of Natural Killer Cells
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Natural Killer Cells in Human Aging
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HIV Infection as a Model of Accelerated Immunosenescence
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- Authors
- Bayard, C., Lepetitcorps, H., Roux, A., Larsen, M., Fastenackels, S., Salle, V., Vieillard, V., Marchant, A., Stern, M., Boddaert, J., Bajolle, F., Appay, V., & Sauce, D.
- Affiliations
- Inserm (FR)
- Centre d'Immunologie et des Maladies Infectieuses (CIMI‐Paris) Sorbonne Universités DHU FAST, CR7, UPMC Univ Paris 06 Paris France
- Hôpital Necker-Enfants Malades (FR)
- Université Libre de Bruxelles (BE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Corresponding author
- Sauce, Delphine
- ORCID
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2016-03-11
- Volume
- 46
- Issue
- 5
- Pages
- 1168-1179
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2277932503
- Cited by
- 65
- References
- 54
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 9 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 8 · 2019: 11 · 2018: 5 · 2017: 5 · 2016: 7
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- HAL (submittedVersion)
- Funders
- Agence de biomédecine (R14107DD)
- Association Grégory Lemarchal (RF20140501153)
- Fondation pour la Recherche Médicale (FRM) (DEQ20120323690)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- human cytomegalovirus, natural killer cells, memory T cells, NKG2C, CD57, viral latency, thymectomy, aging, lung transplant recipients, pregnancy, CD8+ T cells, viral persistence, innate and adaptive immunity
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Cytomegalovirus Infections, Cytomegalovirus, Female, Humans, Immunologic Memory, Killer Cells, Natural, Lymphocyte Activation, Male, Middle Aged, Phenotype, Pregnancy, Pregnancy Complications, Infectious, Lung Transplantation, Virus Latency, CD8-Positive T-Lymphocytes, CD57 Antigens, Young Adult, Healthy Volunteers
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