An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans

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A double-negative (IgD−CD27−) B cell population is increased in the peripheral blood of elderly people

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Cytomegalovirus Infection: A Driving Force in Human T Cell Immunosenescence

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Oxidative Stress, Inflammaging, and Immunosenescence

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Increased Risk of Serious Non-AIDS-Related Events in HIV-Infected Subjects on Antiretroviral Therapy Associated with a Low CD4/CD8 Ratio

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The Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Years

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Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

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No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study

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Dramatic Shifts in Circulating CD4 but not CD8 T Cell Subsets in Mild Alzheimer's Disease

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Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease

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Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection

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Cytomegalovirus Coinfection Is Associated With an Increased Risk of Severe Non–AIDS-Defining Events in a Large Cohort of HIV-Infected Patients

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Senescence of the Human Immune System

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T cells, aging and senescence

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Massive Load of Functional Effector CD4+ and CD8+ T Cells against Cytomegalovirus in Very Old Subjects

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Immunity, ageing and cancer

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The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence

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Immunity and ageing in man

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The CD4/CD8 ratio as a marker T-cell activation, senescence and activation/exhaustion in treated HIV-infected children and young adults

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The CD4/CD8 ratio in HIV-infected subjects is independently associated with T-cell activation despite long-term viral suppression

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On the immunological theory of aging

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Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity

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The CD 4: CD 8 ratio is associated with markers of age‐associated disease in virally suppressed HIV ‐infected patients with immunological recovery

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The impact of CMV infection on survival in older humans

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. Persistent viral infections and immune aging.

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Human cytomegalovirus infection and T cell immunosenescence: A mini review

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Autoimmunity in the Elderly: Insights from Basic Science and Clinics - A Mini-Review

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Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates

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Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: a systematic review

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Effect of age and CMV on NK cell subpopulations

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Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors

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Vaccines to Prevent Infectious Diseases in the Older Population: Immunological Challenges and Future Perspectives

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Elevation and persistence of CD8 T‐cells in HIV infection: the Achilles heel in the ART era

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Host Resistance and Immune Responses in Advanced Age

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From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”

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Is immunosenescence influenced by our lifetime “dose” of exercise?

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Melatonin, Immune Function and Cancer

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Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?

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Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging

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Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

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Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

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Pre-Operative, High-IL-6 Blood Level is a Risk Factor of Post-Operative Delirium Onset in Old Patients

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Role of persistent CMV infection in configuring T cell immunity in the elderly

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Immunosenescence in multiple sclerosis: the identification of new therapeutic targets

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Socioeconomic Differentials in Immune Response

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Zinc, aging, and immunosenescence: an overview

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Human Immunosenescence

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Deep sequencing and flow cytometric characterization of expanded effector memory CD8 ⁺ CD57 ⁺ T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia

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Psychologically adverse work conditions are associated with CD8+ T cell differentiation indicative of immunesenescence

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Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to Cardiometabolic Disease

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Environmental Enrichment Improves Age-Related Immune System Impairment: Long-Term Exposure Since Adulthood Increases Life Span in Mice

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Reactivation of herpes simplex virus type 1 is associated with cytomegalovirus and age

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Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults

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Dynamics of T cell memory in human cytomegalovirus infection

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Upregulation of miR‐24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8+ T cells sensitizing them to apoptotic cell death

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T cell senescence and cardiovascular diseases

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Impact of antiretroviral therapy (ART) timing on chronic immune activation/inflammation and end-organ damage

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Immunologic mechanisms of fingolimod and the role of immunosenescence in the risk of cryptococcal infection: A case report and review of literature

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Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA

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Immunosenescence and Cytomegalovirus: Exploring Their Connection in the Context of Aging, Health, and Disease

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Reference Values for CD4+ and CD8+ T Lymphocytes with Naïve or Memory Phenotype and Their Association with Mortality in the Elderly

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Reversing T cell immunosenescence: why, who, and how

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Nonhuman Primates in Translational Research

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Immunosenescence, inflammation and Alzheimer’s disease

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Why do some people lose teeth across their lifespan whereas others retain a functional dentition into very old age?

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Cytomegalovirus Infection and Memory T Cell Inflation

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Immunosenescence: the Role of Aging in the Predisposition to Neuro-Infectious Complications Arising from the Treatment of Multiple Sclerosis

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Immunosupportive therapies in aging

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An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian

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No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study

Strindhall, J., Nilsson, B.-O., Löfgren, S., Ernerudh, J., Pawelec, G., Johansson, B., & Wikby, A. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.001 · Cited by 209 · see citing works

Inflammatory and immunological markers and risk for mortality and cognitive impairment in a longitudinal study of older adults from the longevous project

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The Immune Risk Phenotype and IL-6 among Nonagenarians and Associations with Morbidity and Mortality : Findings from the Swedish NONA Immune Longitudinal Study

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Peripheral immune signatures predict cognitive decline in older adults: a population-based cohort study

Luan, H., Shan, A., Han, X., Wang, X., Li, S., Wen, B., Sun, Y., Li, C., Sun, Q., & Wei, C. (2026) · Age and Ageing · doi:10.1093/ageing/afag289