The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Continuous Flow Reactors, a Tool for the Modern Synthetic Chemist
Abstract
The competitive nature of the chemical industry means that researchers involved in product development and lead compound generation are under continued pressure to identify, and develop, promising programmes of research in order to secure vital intellectual property. The potential of a compound, however, depends not only on structural complexity, but also on the ability to prepare the compound via a scalable synthetic pathway. Consequently, micro reaction and continuous flow technologies have captured the attention of the modern synthetic chemist as they enable reactions to beperformed with an unprecedented level of control, affording excellent transferability between laboratory based investigations and subsequent production scales. With these features in mind, this Microreview focuses on recent developments made in the field of micro reaction technology, highlighting the advantages associated with its use through the synthesis of a diverse array of molecules.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reactions in Droplets in Microfluidic Channels
Song, H., Chen, D. L., & Ismagilov, R. F. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601554 · Cited by 1,847
Greener Approaches to Organic Synthesis Using Microreactor Technology
Mason, B. P., Price, K. E., Steinbacher, J. L., Bogdan, A. R., & McQuade, D. T. (2007) · Chemical Reviews · doi:10.1021/cr050944c · Cited by 985
Microreactors: New Technology for Modern Chemistry
Ehrfeld, W., Hessel, V., & Löwe, H. (2000) · Wiley eBooks · doi:10.1002/3527601953 · Cited by 778
Microfabrication Inside Capillaries Using Multiphase Laminar Flow Patterning
Kenis, P. J. A., Ismagilov, R. F., & Whitesides, G. M. (1999) · Science · doi:10.1126/science.285.5424.83 · Cited by 659
Microreactors: New Technology for Modern Chemistry
Ehrfeld, W., Hessel, V., & Löwe, H. (2000) · Cited by 619
The impact of microwave synthesis on drug discovery
Kappe, C. O., & Dallinger, D. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1926 · Cited by 610
A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions
Kobayashi, J., Mori, Y., Okamoto, K., Akiyama, R., Ueno, M., Kitamori, T., & Kobayashi, S. (2004) · Science · doi:10.1126/science.1096956 · Cited by 576
Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics
Lee, C.-C., Sui, G., Elizarov, A., Shu, C. J., Shin, Y.-S., Dooley, A. N., Huang, J., Daridon, A., Wyatt, P., Stout, D., et al. (2005) · Science · doi:10.1126/science.1118919 · Cited by 510
Continuous Flow Techniques in Organic Synthesis
Jas, G., & Kirschning, A. (2003) · Chemistry – A European Journal · doi:10.1002/chem.200305212 · Cited by 466
Multistep Continuous‐Flow Microchemical Synthesis Involving Multiple Reactions and Separations
Sahoo, H. R., Kralj, J. G., & Jensen, K. F. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200701434 · Cited by 397
Cited by
Continuous‐Flow Solid‐Phase Peptide Synthesis: A Revolutionary Reduction of the Amino Acid Excess
Mándity, I. M., Olasz, B., Ötvös, S. B., & Fülöp, F. (2014) · ChemSusChem · doi:10.1002/cssc.201402436 · Cited by 65
Metadata
- Authors
- Wiles, C., & Watts, P.
- Venue
- European Journal of Organic Chemistry
- Publisher
- Wiley
- Published
- 2008-03-12
- Volume
- 2008
- Issue
- 10
- Pages
- 1655-1671
- ISSN
- 1099-0690 (ISSN-L)
- 1434-193X
- OpenAlex
- W1980636327
- Cited by
- 310
- References
- 43
- FWCI
- 26.65
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Continuous Flow Reactors, a Tool for the Modern Synthetic Chemist. https://app.cochat.ai/papers/10.1002/ejoc.200701041
- The paper
- Wiles, C., & Watts, P. (2008). Continuous Flow Reactors, a Tool for the Modern Synthetic Chemist. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.200701041
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
