The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics
Abstract
Microreactor technology has shown potential for optimizing synthetic efficiency, particularly in preparing sensitive compounds. We achieved the synthesis of an [ 18 F]fluoride-radiolabeled molecular imaging probe, 2-deoxy-2-[ 18 F]fluoro- d -glucose ([ 18 F]FDG), in an integrated microfluidic device. Five sequential processes—[ 18 F]fluoride concentration, water evaporation, radiofluorination, solvent exchange, and hydrolytic deprotection—proceeded with high radio-chemical yield and purity and with shorter synthesis time relative to conventional automated synthesis. Multiple doses of [ 18 F]FDG for positron emission tomography imaging studies in mice were prepared. These results, which constitute a proof of principle for automated multistep syntheses at the nanogram to microgram scale, could be generalized to a range of radiolabeled substrates.
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Citations
Cites
Solvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic Devices
Lee, J. N., Park, C., & Whitesides, G. M. (2003) · Analytical Chemistry · doi:10.1021/ac0346712 · Cited by 2,643
Cited by
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
Microchemical systems for continuous-flow synthesis
Hartman, R. L., & Jensen, K. F. (2009) · Lab on a Chip · doi:10.1039/b906343a · Cited by 508
Du, W., Li, L., Nichols, K. P., & Ismagilov, R. F. (2009) · Lab on a Chip · doi:10.1039/b908978k · Cited by 351
Continuous Flow Reactors, a Tool for the Modern Synthetic Chemist
Wiles, C., & Watts, P. (2008) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200701041 · Cited by 310
Metadata
- Authors
- Lee, C.-C., Sui, G., Elizarov, A., Shu, C. J., Shin, Y.-S., Dooley, A. N., Huang, J., Daridon, A., Wyatt, P., Stout, D., Kolb, H. C., Witte, O. N., Satyamurthy, N., Heath, J. R., Phelps, M. E., Quake, S. R., & Tseng, H.-R.
- Venue
- Science
- Published
- 2005-12-16
- Volume
- 310
- Issue
- 5755
- Pages
- 1793-1796
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2148626564
- Cited by
- 510
- References
- 1
- FWCI
- 25.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, C.-C., Sui, G., Elizarov, A., Shu, C. J., Shin, Y.-S., Dooley, A. N., Huang, J., Daridon, A., Wyatt, P., Stout, D., Kolb, H. C., Witte, O. N., Satyamurthy, N., Heath, J. R., Phelps, M. E., Quake, S. R., & Tseng, H.-R. (2005). Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics. Science. https://doi.org/10.1126/science.1118919
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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