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Cited by 56Migraine and Headache StudiesMusculoskeletal pain and rehabilitationPain Mechanisms and Treatments

Increased pain sensitivity in migraine and tension-type headache coexistent with low back pain: a cross-sectional population study

Ashina, S., Lipton, R.B., Bendtsen, L., Hajiyeva, N., Buse, D.C., Lyngberg, A.C., Jensen, R.·2018·European Journal of Pain
DOI 10.1002/ejp.1176
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Abstract

BACKGROUND: Low back pain is common in the general population and in individuals with primary headaches. We assessed the relative frequency of self-reported back pain in persons with and without primary headaches and examined pain sensitivity. METHOD: A population of 796 individuals completed a headache interview based on ICHD criteria and provided data of interest in a self-administered questionnaire. Headache cases were classified into chronic (≥15) (CH) or episodic (<15 headache days/month) (EH). A total of 495 had a pericranial total tenderness score (TTS), and 494 had cephalic and extracephalic pressure pain thresholds (PPTs) assessed. RESULTS: Adjusted for age, gender, education and poor self-rated health, 1-year relative frequency of back pain was higher in individuals with CH (82.5%) and EH (80.1%) compared to no headache group (65.7%). In persons with back pain, TTS was higher in CH, (26.3 ± 12.1) than in EH, (18.5 ± 10.0; p < 0.001) and higher in both groups than in those with no headache, 10.8 ± 8.5 (p < 0.001 and p < 0.001, respectively). In persons with back pain, temporalis PPT were lower in CH, 169.3 ± 57.8, than in EH, 225.2 ± 98.1, and in no headache group, 244.3 ± 105.4 (p = 0.02 and p = 0.01, respectively). In persons with back pain, finger PPT were lower in CH, 237.1 ± 106.7, than in EH, 291.3 ± 141.3, or in no headache group, 304.3 ± 137.4 (p = 0.02 and p < 0.001, respectively). CONCLUSION: Back pain is highly frequent in individuals with CH, followed by EH and no headache. In persons with CH, back pain is associated with lower cephalic and extracephalic PPTs suggesting central sensitization may be a substrate or consequence of comorbidity. SIGNIFICANCE: We found that back pain has high relative frequency in individuals with CH followed EH and no headache. Back pain is associated with low cephalic and extracephalic PPTs in individuals with CH. Central sensitization may be a substrate or consequence of this comorbidity of back pain and CH.

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  • Comorbidity of other pain and mental states (depression and anxiety) is characteristic of women with migraine diagnosis and has been reported in previous chronic pain studies, suggesting that the mechanism of central sensitization may be a substrate or consequence of comorbidity.

    “The comorbidity of other pain and mental states (depression and anxiety) is characteristic of women with migraine diagnosis and has been reported in previous chronic pain studies (Allais et al., 2020; Xu et al., 2020), suggesting that the mechanism of central sensitization may be a substrate or consequence of comorbidity (Ashina et al., 2018).”

    From The Development of Mindful-Based Dance Movement Therapy Intervention for Chronic Pain: A Pilot Study With Chronic Headache Patients (2021) · cites this paper as Ashina et al., 2018

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Authors
Ashina, S., Lipton, R. B., Bendtsen, L., Hajiyeva, N., Buse, D. C., Lyngberg, A. C., & Jensen, R.
Affiliations
  • University of Copenhagen (DK)
  • Albert Einstein College of Medicine (US)
  • Capital Region of Denmark (DK)
Corresponding author
Ashina, S.
ORCID
Venue
European Journal of Pain
Publisher
Wiley
Published
2018-01-19
Volume
22
Issue
5
Pages
904-914
ISSN
  • 1090-3801 (ISSN-L)
  • 1532-2149
DOI
10.1002/ejp.1176
OpenAlex
W2793688320
Cited by
56
References
49
Citations by year
2026: 4 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 16 · 2020: 2 · 2019: 7 · 2018: 2
FWCI
5.30
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • European Journal of Pain (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • GlaxoSmithKline
  • Merck Sharp and Dohme
  • Pfizer
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
migraine, tension-type headache, low back pain, pain sensitivity, pressure pain threshold, tenderness, central sensitization, chronic headache, episodic headache, temporalis muscle, primary headache, self-rated health
MeSH terms
Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Migraine Disorders, Surveys and Questionnaires, Comorbidity, Prevalence, Low Back Pain, Pain Threshold, Tension-Type Headache, Young Adult, Self Report

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