Brain microvessel cross‐presentation is a hallmark of experimental cerebral malaria

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis

Brochet, X., Lefranc, M., & Giudicelli, V. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn316 · Cited by 1,220 · see citing works

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

Limmer, A., Ohl, J., Kurts, C., Ljunggren, H.-G., Reiss, Y., Groettrup, M., Momburg, F., Arnold, B., & Knolle, P. A. (2000) · Nature Medicine · doi:10.1038/82161 · Cited by 758 · cited 1× · see citing works

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

Carlton, J. M., Angiuoli, S. V., Suh, B. B., Kooij, T. W. A., Pertea, M., da Silva, J. C. F., Ermolaeva, M. D., Allen, J., Selengut, J., Koo, H. L., et al. (2002) · Nature · doi:10.1038/nature01099 · Cited by 734 · see citing works

Cross-priming in health and disease

Kurts, C., Robinson, B. W. S., & Knolle, P. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2780 · Cited by 427 · see citing works

Neurological sequelae of cerebral malaria in children

Brewster, D., Kwiatkowski, D. P., & White, N. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)92498-7 · Cited by 407 · see citing works

LacZ inducible, antigen/MHC-specific T cell hybrids

Sanderson, S., & Shastri, N. (1994) · International Immunology · doi:10.1093/intimm/6.3.369 · Cited by 381 · see citing works

Design and use of conditional MHC class I ligands

Toebes, M., Coccoris, M., Bins, A. D., Rodenko, B., Gomez, R., Nieuwkoop, N. J., van de Kasteele, W., Rimmelzwaan, G. F., Haanen, J. B. A. G., Ovaa, H., et al. (2006) · Nature Medicine · doi:10.1038/nm1360 · Cited by 348 · see citing works

On the Pathogenic Role of Brain-Sequestered αβ CD8+ T Cells in Experimental Cerebral Malaria

Belnoue, E., Kayibanda, M., Vigário, A. M., Deschemin, J., van Rooijen, N., Viguier, M., Snounou, G., & Rénia, L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6369 · Cited by 341 · see citing works

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

Lund, A. W., Durães, F. V., Hirosue, S., Raghavan, V. R., Nembrini, C., Thomas, S. N., Issa, A., Hugues, S., & Swartz, M. A. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.01.005 · Cited by 341 · see citing works

Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration

Franke-Fayard, B. M. D., Janse, C. J., Cunha‐Rodrigues, M., Ramesar, J., Büscher, P., Que, I., Löwik, C. W. G. M., Voshol, P. J., den Boer, M. A. M., van Duinen, S. G., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503386102 · Cited by 331 · see citing works

The Role of Animal Models for Research on Severe Malaria

Craig, A. G., Grau, G. E., Janse, C. J., Kazura, J. W., Milner, D. A., Barnwell, J. W., Turner, G. D. H., & Langhorne, J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002401 · Cited by 321 · see citing works

Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene

Burnett, S. H., Kershen, E. J., Zhang, J., Zeng, L., Straley, S. C., Kaplan, A. M., & Cohen, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0903442 · Cited by 307 · see citing works

Perforin-Dependent Brain-Infiltrating Cytotoxic CD8+ T Lymphocytes Mediate Experimental Cerebral Malaria Pathogenesis

Nitcheu, J., Bonduelle, O., Combadière, C., Tefit, M., Seilhean, D., Mazier, D., & Combadière, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2221 · Cited by 288 · see citing works

Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria

Yañez, D. M., Manning, D. D., Cooley, A. J., Weidanz, W. P., & van der Heyde, H. C. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.4.1620 · Cited by 267 · see citing works

Locally Up-regulated Lymphotoxin α, Not Systemic Tumor Necrosis Factor α, Is the Principle Mediator of Murine Cerebral Malaria

Engwerda, C. R., Mynott, T. L., Sawhney, S., de Souza, J. B., Bickle, Q. D., & Kaye, P. M. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020128 · Cited by 257 · see citing works

Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8+ T Cells

Savinov, A., Wong, F., Stonebraker, A. C., & Chervonsky, A. (2003) · Journal of Experimental Medicine · doi:10.1084/jem.20021378 · Cited by 220 · see citing works

A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development

Malleret, B., Claser, C., Ong, A. S. M., Suwanarusk, R., Sriprawat, K., Howland, S. W., Russell, B., Nosten, F. H., & Rénia, L. (2011) · Scientific Reports · doi:10.1038/srep00118 · Cited by 202 · see citing works

Blood-stage Plasmodium infection induces CD8 + T lymphocytes to parasite-expressed antigens, largely regulated by CD8α + dendritic cells

Lundie, R. J., de Koning‐Ward, T. F., Davey, G. M., Nie, C. Q., Hansen, D. S., Lau, L. S., Mintern, J. D., Belz, G. T., Schofield, L., Carbone, F. R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806727105 · Cited by 190 · see citing works

Granzyme B Expression by CD8+ T Cells Is Required for the Development of Experimental Cerebral Malaria

Haque, A., Best, S. E., Unosson, K., Amante, F. H., Rivera, F. D. L., Anstey, N. M., Karupiah, G., Smyth, M. J., Heath, W. R., & Engwerda, C. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003955 · Cited by 188 · see citing works

IFN-γ–Producing CD4+ T Cells Promote Experimental Cerebral Malaria by Modulating CD8+ T Cell Accumulation within the Brain

Villegas-Méndez, A., Greig, R., Shaw, T. N., de Souza, J. B., Findlay, E. G., Stumhofer, J. S., Hafalla, J. C. R., Blount, D. G., Hunter, C. A., Riley, E. M., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200688 · Cited by 175 · see citing works

Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria

Amante, F. H., Haque, A., Stanley, A. C., Rivera, F. D. L., Randall, L. M., Wilson, Y. A., Yeo, G., Pieper, C., Crabb, B. S., de Koning‐Ward, T. F., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000944 · Cited by 173 · see citing works

Plasmodium falciparum–infected erythrocytes induce NF-κB regulated inflammatory pathways in human cerebral endothelium

Tripathi, A. K., Sha, W., Shulaev, V., Stins, M. F., & Sullivan, D. J. (2009) · Blood · doi:10.1182/blood-2009-06-226415 · Cited by 166 · see citing works

Accumulation of Plasmodium berghei -Infected Red Blood Cells in the Brain Is Crucial for the Development of Cerebral Malaria in Mice

Baptista, F. G., Pamplona, A., Pena, A. C., Mota, M. M., Pied, S., & Vigário, A. M. (2010) · Infection and Immunity · doi:10.1128/iai.00079-10 · Cited by 163 · see citing works

ExperimentalModels of Cerebral Malaria

Engwerda, C. R., Belnoue, E., Grüner, A. C., & Rénia, L. (2005) · Current topics in microbiology and immunology · doi:10.1007/3-540-29967-x_4 · Cited by 154 · see citing works

CD8+ T Cells and IFN-γ Mediate the Time-Dependent Accumulation of Infected Red Blood Cells in Deep Organs during Experimental Cerebral Malaria

Claser, C., Malleret, B., Gun, S. Y., Wong, A. Y. W., Chang, Z. W., Teo, P., See, P., Howland, S. W., Ginhoux, F., & Rénia, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018720 · Cited by 143 · see citing works

Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria

Potter, S. M., Chan‐Ling, T., Ball, H. J., Mansour, H., Mitchell, A. J., Maluish, L., & Hunt, N. H. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2005.12.005 · Cited by 137 · see citing works

Cerebral malaria

Rénia, L., Howland, S. W., Claser, C., Grüner, A. C., Suwanarusk, R., Teo, T., Russell, B., & Ng, L. F. P. (2012) · Virulence · doi:10.4161/viru.19013 · Cited by 137 · see citing works

Breakdown of the blood-brain barrier in murine cerebral malaria

Thumwood, C. M., Hunt, N. H., Clark, I. A., & Cowden, W. B. (1988) · Parasitology · doi:10.1017/s0031182000080203 · Cited by 137 · see citing works

Control of pathogenic CD8+ T cell migration to the brain by IFN‐γ during experimental cerebral malaria

Belnoue, E., Potter, S. M., Rosa, D. S., Mauduit, M., Grüner, A. C., Kayibanda, M., Mitchell, A. J., Hunt, N. H., & Rénia, L. (2008) · Parasite Immunology · doi:10.1111/j.1365-3024.2008.01053.x · Cited by 130 · see citing works

Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation

Belizaire, R., & Unanue, E. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908583106 · Cited by 126 · see citing works

Cutting Edge: Conventional Dendritic Cells Are the Critical APC Required for the Induction of Experimental Cerebral Malaria

deWalick, S., Amante, F. H., McSweeney, K. A., Randall, L. M., Stanley, A. C., Haque, A., Kuns, R. D., MacDonald, K. P. A., Hill, G. R., & Engwerda, C. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6033 · Cited by 123 · see citing works

Pathogenic T cells in cerebral malaria

Rénia, L., Potter, S. M., Mauduit, M., Rosa, D. S., Kayibanda, M., Deschemin, J., Snounou, G., & Grüner, A. C. (2006) · International Journal for Parasitology · doi:10.1016/j.ijpara.2006.02.007 · Cited by 117 · see citing works

Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions

Jambou, R., Combes, V., Jambou, M.-J., Weksler, B. B., Couraud, P., & Grau, G. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001021 · Cited by 116 · see citing works

Cutting Edge: Clec9A+ Dendritic Cells Mediate the Development of Experimental Cerebral Malaria

Piva, L., Tetlak, P., Claser, C., Karjalainen, K., Rénia, L., & Ruedl, C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201171 · Cited by 115 · see citing works

A simple method for isolation and characterization of mouse brain microvascular endothelial cells

Wu, Z., Hofman, F. M., & Zloković, B. V. (2003) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(03)00206-1 · Cited by 114 · see citing works

Efficient Cross-Presentation by Heat Shock Protein 90-Peptide Complex-Loaded Dendritic Cells via an Endosomal Pathway

Kurotaki, T., Tamura, Y., Ueda, G., Oura, J., Kutomi, G., Hirohashi, Y., Sahara, H., Torigoe, T., Hiratsuka, H., Sunakawa, H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1803 · Cited by 107 · see citing works

The epileptogenic action of Na-folate in the rat

Hommes, O. R., & Obbens, E. A. M. T. (1972) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(72)90192-x · Cited by 90 · see citing works

Blood-brain barrier breakdown during cerebral malaria: Suicide or murder?

Pino, P., Taoufiq, Z., Nitcheu, J., Vouldoukis, I., & Mazier, D. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-05-0354 · Cited by 89 · see citing works

Genetic control of immunity to Plasmodium yoelii sporozoites.

Weiss, W. R., Good, M. F., Hollingdale, M. R., Miller, L. H., & Berzofsky, J. A. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.12.4263 · Cited by 81 · see citing works

Malaria-Specific and Nonspecific Activation of CD8+ T Cells during Blood Stage of Plasmodium berghei Infection

Miyakoda, M., Kimura, D., Yuda, M., Chinzei, Y., Shibata, Y., Honma, K., & Yui, K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1420 · Cited by 80 · see citing works

Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells #

Schurich, A., Böttcher, J. P., Burgdorf, S., Penzler, P., Hegenbarth, S. I., Kern, M., Dolf, A., Endl, E., Schultze, J. L., Wiertz, E. J. H. J., et al. (2009) · Hepatology · doi:10.1002/hep.23075 · Cited by 80 · see citing works

Discovery of CD8 + T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers

Grotenbreg, G. M., Roan, N. R., Guillén, E., Meijers, R., Wang, J., Bell, G. W., Starnbach, M. N., & Ploegh, H. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711504105 · Cited by 73 · see citing works

Naturally Presented Peptides on Major Histocompatibility Complex I and II Molecules Eluted from Central Nervous System of Multiple Sclerosis Patients

Fissolo, N., Haag, S., de Graaf, K. L., Drews, O., Stevanović, S., Rammensee, H. G., & Weissert, R. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900001-mcp200 · Cited by 67 · see citing works

TNF-induced target cell killing by CTL activated through cross-presentation.

Wohlleber, D., Kashkar, H., Gärtner, K., Frings, M. K., Odenthal, M., Hegenbarth, S., Börner, C., Arnold, B., Hämmerling, G., Nieswandt, B., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.08.001 · Cited by 67 · see citing works

T cell response in malaria pathogenesis: selective increase in T cells carrying the TCR Vβ8 during experimental cerebral malaria

Boubou, M. I., Collette, A., Voegtlé, D., Mazier, D., Cazenave, P., & Pied, S. (1999) · International Immunology · doi:10.1093/intimm/11.9.1553 · Cited by 64 · see citing works

Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria

McQuillan, J. A., Mitchell, A. J., Ho, Y. F., Combes, V., Ball, H. J., Golenser, J., Grau, G. E., & Hunt, N. H. (2010) · International Journal for Parasitology · doi:10.1016/j.ijpara.2010.08.003 · Cited by 59 · see citing works

Mouse Endothelial Cells Cross-Present Lymphocyte-Derived Antigen on Class I MHC via a TAP1- and Proteasome-Dependent Pathway1

Bagai, R. K., Valujskikh, A., Canaday, D., Bailey, E., Lalli, P., Harding, C., & Heeger, P. (2005) · Journal of Immunology · doi:10.4049/jimmunol.174.12.7711 · Cited by 59 · see citing works

PHENOTYPIC CHARACTERIZATION OF A HUMAN SYNOVIAL SARCOMA CELL LINE, SW982, AND ITS RESPONSE TO DEXAMETHASONE

Yamazaki, T., YOKOYAMA, T., Akatsu, H., Tukiyama, T., & Tokiwa, T. (2003) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1290/1543-706x(2003)039 · Cited by 59 · see citing works

Noninvasive Real‐Time Monitoring of Liver‐Stage Development of BioluminescentPlasmodiumParasites

Mwakingwe, A., Ting, L.-M., Hochman, S. E., Chen, J. Y.-S., Sinnis, P., & Kim, K. (2009) · The Journal of Infectious Diseases · doi:10.1086/606115 · Cited by 54 · see citing works

Convulsions Due to Increased Permeability of the Blood‐Brain Barrier in Experimental Cerebral Malaria Can Be Prevented by Splenectomy or Anti‐T Cell Treatment

Hermsen, C. C., Mommers, E. C. M., WIEL, T. V. D., Sauerwein, R. W., & Eling, W. M. C. (1998) · The Journal of Infectious Diseases · doi:10.1086/515691 · Cited by 52 · see citing works

Studies on Sporozoite-Induced Infections of Rodent Malaria

Yoeli, M., & Most, H. (1965) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1965.14.700 · Cited by 49 · see citing works

Blood-Stage Plasmodium berghei Infection Generates a Potent, Specific CD8+ T-Cell Response Despite Residence Largely in Cells Lacking MHC I Processing Machinery

Lau, L. S., Fernandez‐Ruiz, D., Davey, G. M., de Koning‐Ward, T. F., Papenfuss, A. T., Carbone, F. R., Brööks, A. G., Crabb, B. S., & Heath, W. R. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir656 · Cited by 47 · see citing works

Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults

Dodoo, D., Hollingdale, M. R., Anum, D., Koram, K. A., Gyan, B. A., Akanmori, B. D., Ocran, J., Adu-Amankwah, S., Geneshan, H., Abot, E. N., et al. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-168 · Cited by 43 · see citing works

Cerebral malaria: in praise of epistemes

Rénia, L., Grüner, A. C., & Snounou, G. (2010) · Trends in Parasitology · doi:10.1016/j.pt.2010.03.005 · Cited by 41 · see citing works

Age-Related Differences in Naturally Acquired T Cell Memory to Plasmodium falciparum Merozoite Surface Protein 1

Chelimo, K., Embury, P. B., Sumba, P. O., VULULE, J. M., Ofulla, A. V. O., Long, C. A., Kazura, J. W., & Moormann, A. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024852 · Cited by 35 · see citing works

Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?

Razakandrainibe, R., Pelleau, S., Grau, G. E., & Jambou, R. (2012) · Trends in Parasitology · doi:10.1016/j.pt.2012.01.004 · Cited by 33 · see citing works

Comprehensive analysis of the functional TCR repertoire at the single-cell level

Ozawa, T., Tajiri, K., Kishi, H., & Muraguchi, A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.011 · Cited by 28 · see citing works

The epileptogenic effects of folate derivatives in the rat

Obbens, E. A. M. T., & Hommes, O. R. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90032-4 · Cited by 27 · see citing works

Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria

Woodberry, T., Pinzón‐Charry, A., Piera, K. A., Panpisutchai, Y., Engwerda, C. R., Doolan, D. L., Salwati, E., Kenangalem, E., Tjitra, E., Price, R. N., et al. (2009) · Malaria Journal · doi:10.1186/1475-2875-8-122 · Cited by 12 · see citing works

Directional, seamless, and restriction enzyme-free construction of random-primed complementary DNA libraries using phosphorothioate-modified primers

Howland, S. W., Poh, C. M., & Rénia, L. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.04.006 · Cited by 8 · see citing works

Untitled work

Tsuchihashi (2000) · doi:10.1002/1521-4141(200006)30:6

The anatomy and immunology of vasculature in the central nervous system

Mastorakos, P., & McGavern, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav0492 · Cited by 333 · see citing works

Malaria Immunity in Man and Mosquito: Insights into Unsolved Mysteries of a Deadly Infectious Disease

Crompton, P. D., Moebius, J., Portugal, S., Waisberg, M., Hart, G. T., Garver, L. S., Miller, L. H., Barillas-Mury, C. V., & Pierce, S. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120220 · Cited by 319 · see citing works

PD-1 Dependent Exhaustion of CD8+ T Cells Drives Chronic Malaria

Horne‐Debets, J. M., Faleiro, R. J., Karunarathne, D. S., Liu, X. Q., Lineburg, K. E., Poh, C. M., Grotenbreg, G. M., Hill, G. R., MacDonald, K. P. A., Good, M. F., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.002 · Cited by 148 · see citing works

The immunological balance between host and parasite in malaria

Deroost, K., Pham, T., Opdenakker, G., & den Steen, P. E. V. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv046 · Cited by 149 · see citing works

CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome

Groß, C. C., Meyer, C., Bhatia, U., Yshii, L., Kleffner, I., Bauer, J., Tröscher, A. R., Schulte‐Mecklenbeck, A., Herich, S., Schneider‐Hohendorf, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13593-5 · Cited by 149 · see citing works

Interferon-γ: The Jekyll and Hyde of Malaria

King, T., & Lamb, T. J. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005118 · Cited by 141 · see citing works

CD8+ T cells target cerebrovasculature in children with cerebral malaria

Riggle, B. A., Manglani, M., Maric, D., Johnson, K. R., Lee, M., Neto, O. L. A., Taylor, T. E., Seydel, K. B., Nath, A., Miller, L. H., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci133474 · Cited by 127 · see citing works

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

Swanson, P. A., Hart, G. T., Russo, M. V., Nayak, D., Yazew, T., Peña, M., Khan, S. M., Janse, C. J., Pierce, S. K., & McGavern, D. B. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1006022 · Cited by 125 · see citing works

Activated Brain Endothelial Cells Cross-Present Malaria Antigen

Howland, S. W., Poh, C. M., & Rénia, L. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004963 · Cited by 110 · see citing works

Tissue-specific immunopathology during malaria infection

Coban, C., Lee, M. S. J., & Ishii, K. J. (2018) · Nature reviews. Immunology · doi:10.1038/nri.2017.138 · Cited by 110 · see citing works

Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4 + T Cell Immunity

Karunarathne, D. S., Horne‐Debets, J. M., Huang, J. X., Faleiro, R. J., Leow, C. Y., Amante, F. H., Watkins, T. S., Miles, J. J., Dwyer, P., Stacey, K. J., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.017 · Cited by 102 · see citing works

Experimental Cerebral Malaria Pathogenesis—Hemodynamics at the Blood Brain Barrier

Nacer, A., Movilă, A., Sohet, F., Girgis, N. M., Gundra, U. M., Loke, P., Daneman, R., & Frevert, U. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004528 · Cited by 98 · see citing works

The Ins and Outs of Cerebral Malaria Pathogenesis: Immunopathology, Extracellular Vesicles, Immunometabolism, and Trained Immunity

Sierro, F., & Grau, G. E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00830 · Cited by 107 · see citing works

Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment

Song, X., Wei, W., Cheng, W., Zhu, H., Wang, W., Dong, H., & Li, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.939532 · Cited by 95 · see citing works

Pathogenic CD8+ T cells in experimental cerebral malaria

Howland, S. W., Claser, C., Poh, C. M., Gun, S. Y., & Rénia, L. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0476-6 · Cited by 94 · see citing works

A quantitative brain map of experimental cerebral malaria pathology

Strangward, P., Haley, M., Shaw, T. N., Schwartz, J., Greig, R., Mironov, A., de Souza, J. B., Cruickshank, S. M., Craig, A. G., Milner, D. A., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006267 · Cited by 89 · see citing works

Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood–brain barrier integrity?

Polimeni, M., & Prato, M. (2014) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-11-1 · Cited by 87 · see citing works

Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

Gordon, E. B., Hart, G. T., Tran, T. M., Waisberg, M., Akkaya, M., Kim, A. S., Hamilton, S. E., Peña, M., Yazew, T., Qi, C., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516544112 · Cited by 80 · see citing works

Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells

Burrack, K. S., Huggins, M. A., Taras, E., Dougherty, P., Henzler, C. M., Yang, R., Alter, S., Jeng, E. K., Wong, H. C., Felices, M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.012 · Cited by 80 · see citing works

Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections

Kam, Y., Lee, C. Y., Teo, T., Howland, S. W., Amrun, S. N., Lum, F., See, P., Kng, N. Q.-R., Huber, R. G., Xu, M., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92428 · Cited by 75 · see citing works

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

Shaw, T. N., Stewart-Hutchinson, P. J., Strangward, P., Dandamudi, D. B., Coles, J. A., Villegas-Méndez, A., Gallego‐Delgado, J., van Rooijen, N., Zindy, E., Rodrı́guez, A., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005210 · Cited by 79 · see citing works

Real-Time Imaging Reveals the Dynamics of Leukocyte Behaviour during Experimental Cerebral Malaria Pathogenesis

Pai, S., Qin, J., Cavanagh, L. L., Mitchell, A. J., El‐Assaad, F., Jain, R., Combes, V., Hunt, N. H., Grau, G. E., & Weninger, W. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004236 · Cited by 76 · see citing works

Repeated clinical malaria episodes are associated with modification of the immune system in children

Bediako, Y., Adams, R., Reid, A. J., Valletta, J. J., Ndungu, F. M., Sodenkamp, J., Mwacharo, J. K., Ngoi, J. M., Kimani, D., Kai, O. K., et al. (2019) · BMC Medicine · doi:10.1186/s12916-019-1292-y · Cited by 75 · see citing works

Monocyte-derived CD11c+ cells acquire Plasmodium from hepatocytes to prime CD8 T cell immunity to liver-stage malaria

Kurup, S. P., Anthony, S., Hancox, L. S., Vijay, R., Pewe, L. L., Moioffer, S. J., Sompallae, R., Janse, C., Khan, S. M., & Harty, J. (2019) · Cell Host and Microbe · doi:10.1016/j.chom.2019.02.014 · Cited by 67 · see citing works

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis

Pal, P., Daniels, B. P., Oskman, A., Diamond, M., Klein, R. S., & Goldberg, D. E. (2016) · mBio · doi:10.1128/mbio.00617-16 · Cited by 73 · see citing works

CXCL10 stabilizes T cell–brain endothelial cell adhesion leading to the induction of cerebral malaria

Sorensen, E. W., Lian, J., Ozga, A. J., Miyabe, Y., Ji, S., Bromley, S. K., Mempel, T. R., & Luster, A. D. (2018) · JCI Insight · doi:10.1172/jci.insight.98911 · Cited by 69 · see citing works

Lung endothelial cell antigen cross-presentation to CD8+T cells drives malaria-associated lung injury

Claser, C., Nguee, S. Y. T., Balachander, A., Howland, S. W., Becht, É., Gunasegaran, B., Hartimath, S. V., Lee, A. W. Q., Ho, J. T. T., Ong, C. B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12017-8 · Cited by 69 · see citing works

Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria

Hirako, I. C., Ataide, M. A., Faustino, L., de Assis, P. A., Sorensen, E. W., Ueta, H., Araújo, N. M., Menezes, G. B., Luster, A. D., & Gazzinelli, R. T. (2016) · Nature Communications · doi:10.1038/ncomms13277 · Cited by 68 · see citing works

Immunological defense of CNS barriers against infections

Ampie, L., & McGavern, D. B. (2022) · Immunity · doi:10.1016/j.immuni.2022.04.012 · Cited by 63 · see citing works

Cerebral malaria: gamma-interferon redux

Hunt, N. H., Ball, H. J., Hansen, A. M., Khaw, L. T., Guo, J. T., Bakmiwewa, S. M., Mitchell, A. J., Combes, V., & Grau, G. E. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00113 · Cited by 62 · see citing works

Malaria Induces Anemia through CD8+T Cell-Dependent Parasite Clearance and Erythrocyte Removal in the Spleen

Safeukui, I., Gómez, N. D., Adelani, A. A., Burté, F., Afolabi, N. K., Akondy, R. S., Velázquez, P., Holder, A. A., Tewari, R., Buffet, P. A., et al. (2015) · mBio · doi:10.1128/mbio.02493-14 · Cited by 61 · see citing works

Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria

Huggins, M. A., Johnson, H. L., Jin, F., N’Songo, A., Hanson, L., LaFrance, S. J., Butler, N. S., Harty, J. T., & Johnson, A. J. (2017) · Infection and Immunity · doi:10.1128/iai.00985-16 · Cited by 60 · see citing works

Olfactory Plays a Key Role in Spatiotemporal Pathogenesis of Cerebral Malaria

Zhao, H., Aoshi, T., Kawai, S., Mori, Y., Konishi, A., Özkan, M., Fujita, Y., Haseda, Y., Shimizu, M., Kohyama, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.04.008 · Cited by 59 · see citing works

Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria

Gordon, E. B., Hart, G. T., Tran, T. M., Waisberg, M., Akkaya, M., Skinner, J., Zinöcker, S., Peña, M., Yazew, T., Qi, C., et al. (2015) · mBio · doi:10.1128/mbio.00725-15 · Cited by 52 · see citing works

The C-Type Lectin Receptor DCIR Is Crucial for the Development of Experimental Cerebral Malaria

Maglinao, M., Klopfleisch, R., Seeberger, P. H., & Lepenies, B. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203451 · Cited by 47 · see citing works

Brain Endothelium: The “Innate Immunity Response Hypothesis” in Cerebral Malaria Pathogenesis

Pais, T. F., & Penha‐Gonçalves, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03100 · Cited by 43 · see citing works

Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?

Butler, N. S., Harris, T. H., & Blader, I. J. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.10.002 · Cited by 41 · see citing works

Dual modal ultra-bright nanodots with aggregation-induced emission and gadolinium-chelation for vascular integrity and leakage detection

Feng, G., Li, J. L. Y., Claser, C., Balachander, A., Tan, Y., Goh, C. C., Kwok, I., Rénia, L., Tang, B. Z., Ng, L. G., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.031 · Cited by 41 · see citing works

Damage to the Blood-Brain Barrier during Experimental Cerebral Malaria Results from Synergistic Effects of CD8+T Cells with Different Specificities

Poh, C. M., Howland, S. W., Grotenbreg, G. M., & Rénia, L. (2014) · Infection and Immunity · doi:10.1128/iai.02180-14 · Cited by 40 · see citing works

Profiling MHC II immunopeptidome of blood‐stage malaria reveals that cDC1 control the functionality of parasite‐specific CD4 T cells

Draheim, M., Wlodarczyk, M. F., Crozat, K., Saliou, J., Alayi, T. D., Tomavo, S., Hassan, A., Salvioni, A., Demarta‐Gatsi, C., Sidney, J., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201708123 · Cited by 39 · see citing works

Interferons and Interferon Regulatory Factors in Malaria

Gun, S. Y., Claser, C., Tan, K. S. W., & Rénia, L. (2014) · Mediators of Inflammation · doi:10.1155/2014/243713 · Cited by 38 · see citing works

SARS-CoV-2 Infection Remodels the Phenotype and Promotes Angiogenesis of Primary Human Lung Endothelial Cells

Caccuri, F., Bugatti, A., Zani, A., Palma, A. D., Silvestre, D. D., Manocha, E., Filippini, F., Messali, S., Chiodelli, P., Campisi, G., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9071438 · Cited by 38 · see citing works

Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses

Doll, K. L., Pewe, L. L., Kurup, S. P., & Harty, J. T. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600155 · Cited by 37 · see citing works

EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria

Darling, T. K., Mimche, P. N., Bray, C., Umaru, B. A., Brady, L. M., Stone, C., Moukoko, C. E. E., Lane, T. E., Ayong, L. S., & Lamb, T. J. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008261 · Cited by 35 · see citing works

Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites

Hopp, C. S., Bennett, B. L., Mishra, S., Lehmann, C., Hanson, K. K., Lin, J., Rousseau, K. E., Carvalho, F. A., van der Linden, W. A., Santos, N. C., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006586 · Cited by 33 · see citing works

Co‐infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium‐induced neuropathology

Teo, T., Howland, S. W., Claser, C., Gun, S. Y., Poh, C. M., Lee, W. W. L., Lum, F., Ng, L. F. P., & Rénia, L. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707885 · Cited by 33 · see citing works

CD8+ T cells and human cerebral malaria: a shifting episteme

Rénia, L., Grau, G. E., & Wassmer, S. C. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135510 · Cited by 33 · see citing works

Pathogenetic mechanisms and treatment targets in cerebral malaria

Hadjilaou, A., Brandi, J., Riehn, M., Friese, M. A., & Jacobs, T. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00881-4 · Cited by 34 · see citing works

Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators

Schmidt, K. E., Kuehlwein, J. M., Schumak, B., Alferink, J., Hofmann, A., Howland, S. W., Rénia, L., Limmer, A., Specht, S., & Hoerauf, A. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192717 · Cited by 32 · see citing works

Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model

Lacerda‐Queiroz, N., Riteau, N., Eastman, R. T., Bock, K. W., Orandle, M. S., Moore, I. N., Sher, A., Long, C. A., Jankovic, D. L., & Su, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-10776-2 · Cited by 31 · see citing works

From the blood to the brain: avenues of eukaryotic pathogen dissemination to the central nervous system

Ueno, N., & Lodoen, M. B. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2015.05.006 · Cited by 29 · see citing works

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene

Budimir, N., Gras, S., Ladell, K., Josephs, T. M., Pewe, L. L., Urban, S. L., Miners, K. L., Farenc, C., Price, D. A., Rossjohn, J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.013 · Cited by 29 · see citing works

The kynurenine pathway and parasitic infections that affect CNS function.

Hunt, N., Too, L. K., Khaw, L., Guo, J.-T., Hee, L., Mitchell, A., Grau, G., & Ball, H. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.029 · Cited by 29 · see citing works

Dendritic cell function and antigen presentation in malaria.

Cockburn, I., & Zavala, F. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.01.010 · Cited by 28 · see citing works

The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2

Harit, K., Bhattacharjee, R., Matuschewski, K., Becker, J. S., Kalinke, U., Schlüter, D., & Nishanth, G. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06014-5 · Cited by 28 · see citing works

Unravelling mysteries at the perivascular space: a new rationale for cerebral malaria pathogenesis

Wassmer, S. C., de Koning‐Ward, T. F., Grau, G. E., & Pai, S. (2023) · Trends in Parasitology · doi:10.1016/j.pt.2023.11.005 · Cited by 27 · see citing works

Mice lacking Programmed cell death-1 show a role for CD8+ T cells in long-term immunity against blood-stage malaria

Horne‐Debets, J. M., Karunarathne, D. S., Faleiro, R. J., Poh, C. M., Rénia, L., & Wykes, M. (2016) · Scientific Reports · doi:10.1038/srep26210 · Cited by 26 · see citing works

Spatiotemporal requirements for IRF7 in mediating type I IFN‐dependent susceptibility to blood‐stage Plasmodium infection

Edwards, C. L., Best, S. E., Gun, S. Y., Claser, C., James, K. R., de, M. M., Sebina, I., Rivera, F. D. L., Amante, F. H., Hertzog, P. J., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201444824 · Cited by 24 · see citing works

Measuring antigen presentation in mouse brain endothelial cells ex vivo and in vitro

Howland, S., Gun, S., Claser, C., Poh, C., & Rénia, L. (2015) · Nature Protocols · doi:10.1038/nprot.2015.129 · Cited by 26 · see citing works

The Deubiquitinating Enzyme Cylindromatosis Dampens CD8+ T Cell Responses and Is a Critical Factor for Experimental Cerebral Malaria and Blood–Brain Barrier Damage

Schmid, U., Stenzel, W., Koschel, J., Raptaki, M., Wang, X., Naumann, M., Matuschewski, K., Schlüter, D., & Nishanth, G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00027 · Cited by 25 · see citing works

Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice

Pal, P., Balaban, A. E., Diamond, M., Sinnis, P., Klein, R. S., & Goldberg, D. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177142 · Cited by 24 · see citing works

Mouse Models for Unravelling Immunology of Blood Stage Malaria

Olatunde, A., Cornwall, D. H., Roedel, M., & Lamb, T. J. (2022) · Vaccines · doi:10.3390/vaccines10091525 · Cited by 23 · see citing works

Host Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling

Claser, C., de Souza, J. B., Thorburn, S. G., Grau, G. E., Riley, E. M., Rénia, L., & Hafalla, J. C. R. (2017) · Infection and Immunity · doi:10.1128/iai.00941-16 · Cited by 23 · see citing works

Perivascular macrophages create an intravascular niche for CD8 + T cell localisation prior to the onset of fatal experimental cerebral malaria

Qin, J., Lovelace, M. D., Mitchell, A. J., de Koning‐Ward, T. F., Grau, G. E., & Pai, S. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1273 · Cited by 22 · see citing works

Beyond the microcirculation: sequestration of infected red blood cells and reduced flow in large draining veins in experimental cerebral malaria

Oelschlegel, A. M., Bhattacharjee, R., Wenk, P., Harit, K., Rothkötter, H.-J., Koch, S., Boehm‐Sturm, P., Matuschewski, K., Budinger, E., Schlüter, D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46617-w · Cited by 22 · see citing works

Endothelial type I interferon response and brain diseases: identifying STING as a therapeutic target

Duarte, N., Shafi, A. M., Penha‐Gonçalves, C., & Pais, T. F. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1249235 · Cited by 20 · see citing works

PDL1 Fusion Protein Protects Against Experimental Cerebral Malaria via Repressing Over-Reactive CD8+ T Cell Responses

Wang, J., Li, Y., Shen, Y., Liang, J., Li, Y., Huang, Y., Liu, X., Jiang, D., Yang, S., Zhao, Y., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03157 · Cited by 20 · see citing works

The Liver-Stage Plasmodium Infection Is a Critical Checkpoint for Development of Experimental Cerebral Malaria

Sato, Y., Ries, S., Stenzel, W., Fillatreau, S., & Matuschewski, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02554 · Cited by 20 · see citing works

Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression

Lewis, M. D., Behrends, J., Cunha, C. S. E., Mendes, A. M., Lasitschka, F., Sattler, J. M., Heiß, K., Kooij, T. W. A., Prudêncio, M., Bringmann, G., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1400863 · Cited by 19 · see citing works

Role of IL-10 in inhibiting protective immune responses against infection with heterologous Plasmodium parasites

Nakamae, S., Kimura, D., Miyakoda, M., Sukhbaatar, O., Inoue, S., & Yui, K. (2019) · Parasitology International · doi:10.1016/j.parint.2019.01.003 · Cited by 19 · see citing works

The immunomodulatory effect of microglia on ECM neuroinflammation via the PD‐1/PD‐L1 pathway

Shen, Y., Li, Y., Zhu, Q., Wang, J., Huang, Y., Liang, J., Wu, X., & Zhao, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13760 · Cited by 17 · see citing works

Cross-presentation by the others

Mauvais, F., & Endert, P. V. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101764 · Cited by 17 · see citing works

The Subcellular Location of Ovalbumin in Plasmodium berghei Blood Stages Influences the Magnitude of T-Cell Responses

Lin, J., Shaw, T. N., Annoura, T., Aurélie, F., Bouchier, P., Chevalley, S., Kroeze, H., Franke-Fayard, B. M. D., Janse, C. J., Couper, K. N., et al. (2014) · Infection and Immunity · doi:10.1128/iai.01940-14 · Cited by 18 · see citing works

The combined deficiency of immunoproteasome subunits affects both the magnitude and quality of Pathogen- and genetic vaccination- induced CD8+ T Cell responses to the human Protozoan parasite Trypanosoma cruzi

Ersching, J., Vasconcelos, J. R., Ferreira, C. P., Caetano, B. C., Machado, A. V., Bruna–Romero, O., Baron, M. A., Ferreira, L. R. P., Cunha-Neto, E., Rock, K. L., et al. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1005593 · Cited by 18 · see citing works

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

Piatti, L., Batzilla, A., Nakaki, F., Fleckenstein, H., Korbmacher, F., Long, R. K. M., Schraivogel, D., Hawkins, J. A., Romero-Uruñuela, T., López-Gutiérrez, B., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62514-2 · Cited by 17 · see citing works

Plasmodium berghei Hsp90 contains a natural immunogenic I-Ab-restricted antigen common to rodent and human Plasmodium species

Enders, M. H., Bayarsaikhan, G., Ghilas, S., Yu, C.-C., May, R., de Menezes, M. N., Ge, Z.-Y., Tan, P., Cozijnsen, A., Mollard, V., et al. (2021) · Current Research in Immunology · doi:10.1016/j.crimmu.2021.06.002 · Cited by 14 · see citing works

Interferon regulatory factor 1 is essential for pathogenic CD8+ T cell migration and retention in the brain during experimental cerebral malaria

Gun, S. Y., Claser, C., Teo, T. H., Howland, S. W., Poh, C. M., Chye, R. R. Y., Ng, L. F. P., & Rénia, L. (2017) · Cellular Microbiology · doi:10.1111/cmi.12819 · Cited by 17 · see citing works

Synergistic induction of CXCL10 by interferon-gamma and lymphotoxin-alpha in astrocytes: Possible role in cerebral malaria

Bakmiwewa, S. M., Weiser, S., Grey, M., Heng, B., Guillemin, G. J., Ball, H. J., & Hunt, N. H. (2015) · Cytokine · doi:10.1016/j.cyto.2015.11.024 · Cited by 16 · see citing works

Discrete class I molecules on brain endothelium differentially regulate neuropathology in experimental cerebral malaria

Fain, C. E., Zheng, J., Jin, F., Ayasoufi, K., Wu, Y., Lilley, M. T., Dropik, A. R., Wolf, D. M., Rodriguez, R. C., Aibaidula, A., et al. (2023) · Brain · doi:10.1093/brain/awad319 · Cited by 17 · see citing works

The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatment

Chen, J., Bai, Y., He, X., Xiao, W. L., Chen, L., Wong, Y., Wang, C., Gao, P., Cheng, G., Xu, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-52223-7 · Cited by 17 · see citing works

HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage

Muscate, F., Stetter, N., Schramm, C., Wiesch, J. S. Z., Bosurgi, L., & Jacobs, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02611 · Cited by 15 · see citing works

Increased Expression of Multiple Co-Inhibitory Molecules on Malaria-Induced CD8+ T Cells Are Associated With Increased Function Instead of Exhaustion

Brandi, J., Riehn, M., Hadjilaou, A., & Jacobs, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.878320 · Cited by 14 · see citing works

ELISPOT Assay to Measure Peptide-specific IFN-γ Production

Wykes, M., & Rénia, L. (2017) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2302 · Cited by 14 · see citing works

BCG Provides Short-Term Protection from Experimental Cerebral Malaria in Mice

Witschkowski, J., Behrends, J., Frank, R., Eggers, L. F., von Borstel, L., Hertz, D., Mueller, A., & Schneider, B. E. (2020) · Vaccines · doi:10.3390/vaccines8040745 · Cited by 14 · see citing works

Targeting Angiotensin II Type-1 Receptor (AT1R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8+ T Cells during Blood-Stage Malaria

Silva‐Filho, J. L., Caruso‐Neves, C., & Pinheiro, A. A. S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00042 · Cited by 14 · see citing works

Brain endothelial cells exposure to malaria parasites links type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption, and cellular metabolism

Shafi, A. M., Végvári, Á., Howland, S. W., Zubarev, R. A., Rénia, L., & Penha‐Gonçalves, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1149107 · Cited by 13 · see citing works

Cross‐presentation of malaria antigen by brain microvessels: why CD8+ T cells are critical for the pathogenesis of experimental cerebral malaria

Yui, K. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302849 · Cited by 13 · see citing works

Evidence of cross‐stage CD 8+ T cell epitopes in malaria pre‐erythrocytic and blood stage infections

Müller, K., Gibbins, M. P., Matuschewski, K., & Hafalla, J. C. R. (2017) · Parasite Immunology · doi:10.1111/pim.12434 · Cited by 13 · see citing works

The plasma membrane calcium ATPase 4 does not influence parasite levels but partially promotes experimental cerebral malaria during murine blood stage malaria

Villegas-Méndez, A., Stafford, N., Haley, M., Pravitasari, N. E., Baudoin, F., Ali, A., Asih, P. B. S., Siregar, J. E., Baena, E., Syafruddin, D., et al. (2021) · Malaria Journal · doi:10.1186/s12936-021-03832-w · Cited by 12 · see citing works

Phosphatidylinositol 3-Kinase γ Is Required for the Development of Experimental Cerebral Malaria

Lacerda‐Queiroz, N., Brant, F., Rodrigues, D. H., Vago, J. P., Rachid, M. A., Sousa, L. P., Teixeira, M. M., & Teixeira, A. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119633 · Cited by 12 · see citing works

A Plasmodium Cross-Stage Antigen Contributes to the Development of Experimental Cerebral Malaria

Fernandes, P., Howland, S. W., Heiß, K., Hoffmann, A., Hernández-Castañeda, M. A., Obrová, K., Frank, R., Wiedemann, P., Bendzus, M., Rénia, L., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01875 · Cited by 11 · see citing works

Protection of Batf3‐deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T‐cell responses and immune regulation

Kuehlwein, J. M., Borsche, M., Korir, P. J., Risch, F., Mueller, A., Hübner, M. P., Hildner, K. M., Hoerauf, A. M., Dunay, I. R., & Schumak, B. (2019) · Immunology · doi:10.1111/imm.13137 · Cited by 11 · see citing works

Increased Neutrophil Percentage and Neutrophil–T Cell Ratio Precedes Clinical Onset of Experimental Cerebral Malaria

Freire-Antunes, L., Ornellas-Garcia, U., Rangel-Ferreira, M. V., Ribeiro-Almeida, M. L., de Sousa, C. H. G., Carvalho, L. J. M., Daniel‐Ribeiro, C. T., & Ribeiro-Gomes, F. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411332 · Cited by 10 · see citing works

Mycobacterium tuberculosis Coinfection Has No Impact on Plasmodium berghei ANKA-Induced Experimental Cerebral Malaria in C57BL/6 Mice

Blank, J., Behrends, J., Jacobs, T., & Schneider, B. E. (2015) · Infection and Immunity · doi:10.1128/iai.01290-15 · Cited by 10 · see citing works

Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii

Imai, T., Suzue, K., Ngo-Thanh, H., Suguri, O., Orita, W., Suzuki, H., Shimokawa, C., Olia, A., Obi, S., Taniguchi, T., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02207 · Cited by 10 · see citing works

Suppression of Plasmodium MIF‐CD74 signaling protects against severe malaria

Garcia, A. B., Siu, E., Du, X., Leng, L., Franke-Fayard, B. M. D., Janse, C. J., Howland, S. W., Rénia, L., Lolis, E., & Bucala, R. (2021) · The FASEB Journal · doi:10.1096/fj.202101072r · Cited by 10 · see citing works

In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factors

Pais, T. F., & Penha‐Gonçalves, C. (2023) · Parasitology Research · doi:10.1007/s00436-023-07782-x · Cited by 9 · see citing works

Exploring immunological mechanisms of the whole sporozoite vaccination against P. falciparum malaria

Mo, A. X. Y., Pesce, J. T., & Hall, B. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.04.056 · Cited by 9 · see citing works

Defining rules of CD8+ T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized mice

Billman, Z. P., Kas, A., Stone, B. C., & Murphy, S. C. (2016) · Malaria Journal · doi:10.1186/s12936-016-1295-5 · Cited by 9 · see citing works

IRGM3 Contributes to Immunopathology and Is Required for Differentiation of Antigen-Specific Effector CD8+T Cells in Experimental Cerebral Malaria

Guo, J. T., McQuillan, J. A., Yau, B., Tullo, G., Long, C. A., Bertolino, P., Roediger, B., Weninger, W., Taylor, G. A., Hunt, N. H., et al. (2015) · Infection and Immunity · doi:10.1128/iai.02701-14 · Cited by 9 · see citing works

Activated Brain Endothelial Cells Cross-Present Malaria Antigen

Howland, S. W., Poh, C. M., & Rénia, L. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004963 · Cited by 110 · see citing works

Present Malaria Antigen

Cross, B. E. C., Howl, S., Poh, C. M., & Rénia, L. (2016)

Antigen-dependent engagement of brain endothelium by CD8 T cells leads to fatal brainstem pathology during cerebral malaria

Swanson, P. A., Hart, G. T., Russo, M. V., Pierce, S. K., & McGavern, D. B. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.196.supp.134.1 · Cited by 1 · see citing works

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

Swanson, P. A., Hart, G. T., Russo, M. V., Nayak, D., Yazew, T., Peña, M., Khan, S. M., Janse, C. J., Pierce, S. K., & McGavern, D. B. (2016) · PLOS Pathogens · doi:10.1371/journal.ppat.1006022 · Cited by 125 · see citing works

Damage to the Blood-Brain Barrier during Experimental Cerebral Malaria Results from Synergistic Effects of CD8+T Cells with Different Specificities

Poh, C. M., Howland, S. W., Grotenbreg, G. M., & Rénia, L. (2014) · Infection and Immunity · doi:10.1128/iai.02180-14 · Cited by 40 · see citing works