Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene

Burnett, Sandra H; Kershen, Edward J; Zhang, Jiayou; Zeng, Li; Straley, Susan C; Kaplan, Alan M; Cohen, Donald A

doi:10.1189/jlb.0903442

Cited by 307Animal Genetics and ReproductionPhagocytosis and Immune RegulationImmunotoxicology and immune responses

Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene

Burnett, Sandra H, Kershen, Edward J, Zhang, Jiayou, Zeng, Li, Straley, Susan C, Kaplan, Alan M, Cohen, Donald A·2004·Journal of Leukocyte Biology

DOI 10.1189/jlb.0903442

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Abstract

Transgenic mice expressing an inducible suicide gene, which allows systemic and reversible elimination of macrophages, were developed. A macrophage-specific c-fms promoter was used to express enhanced green fluorescent protein and a drug-inducible suicide gene that leads to Fas-mediated apoptosis in resting and cycling cells of the macrophage lineage. Transgenic mice were fertile, of normal weight, and showed no abnormal phenotype before drug exposure. The transgene was expressed constitutively in macrophages and dendritic cells (DC) but not significantly in T cells or B cells. Induction of the suicide gene led to depletion of 70–95% of macrophages and DC in nearly all tissues examined. Depletion reduced the ability to clear bacteria from the blood and led to increased bacterial growth in the liver. Depleted mice displayed several abnormalities, including splenomegaly, lymphadenopathy, thymic atrophy, extramedullary hematopoiesis, and development of peritoneal adhesions. This new, transgenic line will be useful in investigating the role of macrophages and DC.

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Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866 · see citing works
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532 · see citing works
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
Dai, X.-M., Ryan, G. R., Hapel, A. J., Dominguez, M. G., Russell, R. G., Kapp, S., Sylvestre, V., & Stanley, E. R. (2002) · Blood · doi:10.1182/blood.v99.1.111 · Cited by 1,184 · see citing works
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130 · see citing works
IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
Chomarat, P., Banchereau, J., Davoust, J. M., & Palucka, K. (2000) · Nature Immunology · doi:10.1038/82763 · Cited by 906 · see citing works
Peritoneal Adhesions: Etiology, Pathophysiology, and Clinical Significance
Liakakos, T., Thomakos, N., Fine, P. M., Dervenis, C., & Young, R. L. (2001) · Digestive Surgery · doi:10.1159/000050149 · Cited by 687 · see citing works
A macrophage colony-stimulating factor receptor–green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse
Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R., & Hume, D. A. (2003) · Blood · doi:10.1182/blood-2002-02-0569 · Cited by 662 · see citing works
Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse
Cecchini, M. G., Dominguez, M. G., Mocci, S., Wetterwald, A., Felix, R., Fleisch, H. A., Chisholm, O., Hofstetter, W., Pollard, J. W., & Stanley, E. R. (1994) · Development · doi:10.1242/dev.120.6.1357 · Cited by 557 · see citing works
Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs
Kamath, A. T., Henri, S., Battye, F. L., Tough, D. F., & Shortman, K. (2002) · Blood · doi:10.1182/blood.v100.5.1734.h81702001734_1734_1741 · Cited by 454 · see citing works
Mesothelial cells: Their structure, function and role in serosal repair
Mutsaers, S. E. (2002) · Respirology · doi:10.1046/j.1440-1843.2002.00404.x · Cited by 436 · see citing works
The mononuclear phagocyte system revisited
Hume, D. A., Ross, I. L., Himes, S. R., Sasmono, R. T., Wells, C. A., & Ravasi, T. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.4.621 · Cited by 425 · see citing works
Peritoneal repair and post-surgical adhesion formation
diZerega, G. S. (2001) · Human Reproduction Update · doi:10.1093/humupd/7.6.547 · Cited by 366 · see citing works
Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase.
Sauer, B., & Henderson, N. (1990) · PubMed · Cited by 259 · see citing works
β-Galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells
Blaser, C., Kaufmann, M., Mueller, C., Zimmermann, C., Wells, V. E., Mallucci, L., & Pircher, H. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199808)28:08 · Cited by 236 · see citing works
Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family
Holness, C. L. L., da Silva, R. P., Fawcett, J., Gordon, S., & Simmons, D. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98400-0 · Cited by 217 · see citing works
Critical roles of neutrophils in host defense against experimental systemic infections of mice by Listeria monocytogenes, Salmonella typhimurium, and Yersinia enterocolitica
Conlan, J. W. (1997) · Infection and Immunity · doi:10.1128/iai.65.2.630-635.1997 · Cited by 208 · see citing works
A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease
Thomis, D. C., Marktel, S., Bonini, C., Traversari, C., Gilman, M. Z., Bordignon, C., & Clackson, T. (2001) · Blood · doi:10.1182/blood.v97.5.1249 · Cited by 204 · see citing works
The role of fibrinolysis in adhesion formation.
Holmdahl, L. (1997) · PubMed · Cited by 187 · see citing works
Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency.
Heyman, R. A., Borrelli, E., Lesley, J., Anderson, D. J., Richman, D. D., Baird, S., Hyman, R., & Evans, R. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2698 · Cited by 174 · see citing works
Fas Ligand Engagement of Resident Peritoneal Macrophages In Vivo Induces Apoptosis and the Production of Neutrophil Chemotactic Factors
Hohlbaum, A. M., Gregory, M. S., Ju, S., & Marshak‐Rothstein, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6217 · Cited by 148 · see citing works
Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization
Spencer, D. M., Belshaw, P. J., Chen, L., Ho, S. N., Randazzo, F. M., Crabtree, G. R., & Schreiber, S. L. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00607-3 · Cited by 144 · see citing works
Growth in mouse peritoneal macrophages of Yersinia pestis lacking established virulence determinants
Straley, S. C., & Harmon, P. (1984) · Infection and Immunity · doi:10.1128/iai.45.3.649-654.1984 · Cited by 128 · see citing works
Self-citation
Gadolinium induces macrophage apoptosis
Mizgerd, J. P., Molina, R. M., Stearns, R. C., Brain, J. D., & Warner, A. E. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.2.189 · Cited by 117 · see citing works
Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation.
Yue, X., Favot, P., Dunn, T. L., Cassady, A. I., & Hume, D. A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3191 · Cited by 86 · see citing works
Experimental Yersinia enterocolitica infection in mice: Kinetics of growth
Carter, P. B., & Collins, F. M. (1974) · Infection and Immunity · doi:10.1128/iai.9.5.851-857.1974 · Cited by 83 · see citing works
Killing of immature CD4+CD8+ thymocytes in vivo by anti‐CD3 or 5′‐(N‐ethyl)‐carboxamido‐adenosine is blocked by glucocorticoid receptor antagonist RU‐486
Jondal, M., Okret, S., & McConkey, D. J. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230608 · Cited by 81 · see citing works
Bacterial/CpG DNA Down-Modulates Colony Stimulating Factor-1 Receptor Surface Expression on Murine Bone Marrow-Derived Macrophages with Concomitant Growth Arrest and Factor-Independent Survival
Sester, D. P., Beasley, S. J., Sweet, M. J., Fowles, L., Cronau, S. L., Stacey, K. J., & Hume, D. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6541 · Cited by 79 · see citing works
Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters
Roberts, W., Shapiro, L., Ashmun, R., & Look, A. T. (1992) · Blood · doi:10.1182/blood.v79.3.586.586 · Cited by 70 · see citing works
A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease
Thomis, D. C., Marktel, S., Bonini, C., et al. (2001) · Blood · doi:10.1182/blood.v97.5.1249.h8001249_1249_1257 · Cited by 69 · see citing works
Cytokine-Induced Inflammatory Liver Injuries
Tsutsui, H., Adachi, K., Seki, E., & Nakanishi, K. (2003) · Current Molecular Medicine · doi:10.2174/1566524033479618 · Cited by 59 · see citing works
Resolution of pluripotential intermediates in murine hematopoietic differentiation by global complementary DNA amplification from single cells: confirmation of assignments by expression profiling of cytokine receptor transcripts
Billia, F., Barbara, M., McEwen, J., Trevisan, M., & Iscove, N. N. (2001) · Blood · doi:10.1182/blood.v97.8.2257 · Cited by 56 · see citing works
Transcription of the human colony-stimulating factor-1 receptor gene is regulated by separate tissue-specific promoters
Roberts, W., Shapiro, L., Ashmun, R., et al. (1992) · Blood · doi:10.1182/blood.v79.3.586.bloodjournal793586 · Cited by 55 · see citing works
Identification of macrophages at the site of peritoneal injury: evidence supporting a direct role for peritoneal macrophages in healing injured peritoneum
Haney, A. F. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00490-8 · Cited by 54 · see citing works
The Macrophage and Fibrinolysis
Loscalzo, J. (1996) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2007-999051 · Cited by 53 · see citing works
Conditional ablation of dendritic cells in transgenic mice.
Salomon, B. L., Lorès, P., Pioche‐Durieu, C., Rácz, P., Jami, J., & Klatzmann, D. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.2.537 · Cited by 52 · see citing works
APOPTOSIS OF THYMOCYTES DURING ACUTE GRAFT-VERSUS-HOST DISEASE IS INDEPENDENT OF GLUCOCORTICOIDS1
Krenger, W., Rossi, S. W., & Holländer, G. A. (2000) · Transplantation · doi:10.1097/00007890-200005270-00040 · Cited by 51 · see citing works
Enhancement of Peritoneal Macrophages Reduces Postoperative Peritoneal Adhesion Formation
Ar'Rajab, A., Dawidson, I. J. A., Sentementes, J. T., Sikes, P., Harris, R., & Mileski, W. J. (1995) · Journal of Surgical Research · doi:10.1006/jsre.1995.1048 · Cited by 51 · see citing works
In-vivo induction of apoptosis in murine lymphocytes by bacterial lipopolysaccharides
Norimatsu, M., Ono, T., Aoki, A., Ohishi, K., & Tamura, Y. (1995) · Journal of Medical Microbiology · doi:10.1099/00222615-43-4-251 · Cited by 51 · see citing works
Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin
Costelloe, E. O., Stacey, K. J., Antalis, T., & Hume, D. A. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.1.172 · Cited by 48 · see citing works
Liposome Mediated Depletion of Macrophages: An Approach for Fundamental Studies
Buiting, A. M. J., & van Rooijen, N. (1994) · Journal of drug targeting · doi:10.3109/10611869408996810 · Cited by 47 · see citing works
In vivo depletion of macrophages by desulfated ι-carrageenan in mice
Ishizaka, S., Kuriyama, S., & Tsuji, T. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90180-4 · Cited by 24 · see citing works
Production of protease inhibitors by postsurgical macrophages
Fukasawa, M., Campeau, J. D., Girgis, W., Bryant, S. M., Rodgers, K. E., & diZerega, G. S. (1989) · Journal of Surgical Research · doi:10.1016/0022-4804(89)90067-x · Cited by 20 · see citing works
Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor
Fowles, L., Stacey, K. J., Marks, D. C., HAMILTON, J. A., & Hume, D. A. (2000) · Biochemical Journal · doi:10.1042/bj3470313 · Cited by 20 · see citing works
Thy-1 tk transgenic mice with a conditional lymphocyte deficiency
Dzierzak, E. A., daly, B., Fraser, P., Larsson, L. C., & Müller, A. M. (1993) · International Immunology · doi:10.1093/intimm/5.8.975 · Cited by 17 · see citing works
IN VIVO REACTIVITY OF T CELL CLONES ISOLATED FROM MICE WITH SYNGENEIC GRAFT-VERSUS-HOST DISEASE
Bryson, J. S., Lake-Bullock, H., Pflugh, D. L., JENNINGS, C. D., Stuart, P. M., CAYWOOD, B. E., & Kaplan, A. M. (1995) · Transplantation · doi:10.1097/00007890-199507000-00010 · Cited by 12 · see citing works
Self-citation
IN VIVO REACTIVITY OF T CELL CLONES ISOLATED FROM MICE WITH SYNGENEIC GRAFT-VERSUS-HOST DISEASE
Bryson, J. S., Lake-Bullock, H., Pflugh, D. L., et al. (1995) · Transplantation · doi:10.1097/00007890-199507270-00010 · Cited by 10 · see citing works
Protection of Mice against Infection with Mouse Hepatitis Virus Type 3 by Injection of Silica
Schindler, L., Brücher, J., & Kirchner, H. (1984) · Immunobiology · doi:10.1016/s0171-2985(84)80144-8 · Cited by 7 · see citing works

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Mesenchymal stem cell-macrophage crosstalk and bone healing
Pajarinen, J., Lin, T., Gibon, E., Kohno, Y., Maruyama, M., Nathan, K., Lu, L. Y., Yao, Z., & Goodman, S. B. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.12.025 · Cited by 1,011 · see citing works
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
Veiseh, O., Doloff, J. C., Ma, M., Vegas, A. J., Tam, H. H., Bader, A. R., Li, J., Langan, E., Wyckoff, J., Loo, W. S., et al. (2015) · Nature Materials · doi:10.1038/nmat4290 · Cited by 897 · see citing works
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
Chow, A. T., Lucas, D., Hidalgo, A., Méndez‐Ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., van Rooijen, N., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101688 · Cited by 866 · see citing works
Origin of the Lamina Propria Dendritic Cell Network
Bogunovic, M., Ginhoux, F., Helft, J., Shang, L., Hashimoto, D., Greter, M., Liu, K., Jakubzick, C., Ingersoll, M. A., Leboeuf, M., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.010 · Cited by 859 · see citing works
In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies
Peters, N. C., Egen, J. G., Secundino, N. F. C., Debrabant, A., Kimblin, N., Kamhawi, S., Lawyer, P. G., Fay, M. P., Germain, R. N., & Sacks, D. L. (2008) · Science · doi:10.1126/science.1159194 · Cited by 837 · see citing works
Commensal–dendritic-cell interaction specifies a unique protective skin immune signature
Naik, S., Bouladoux, N., Linehan, J. L., Han, S.-J., Harrison, O. J., Wilhelm, C., Conlan, S., Himmelfarb, S., Byrd, A. L., Deming, C., et al. (2015) · Nature · doi:10.1038/nature14052 · Cited by 820 · see citing works
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages
Hoeffel, G., Wang, Y., Greter, M., See, P., Teo, P., Malleret, B., Leboeuf, M., Low, D., Oller, G., Almeida, F., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120340 · Cited by 786 · see citing works
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
Nicolás-Ávila, J. A., Lechuga-Vieco, A. V., Esteban-Martínez, L., Sánchez-Díaz, M., Díaz-García, E., Santiago, D. J., Rubio-Ponce, A., Li, J. L., Balachander, A., Quintana, J. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.031 · Cited by 762 · see citing works
The origin and development of nonlymphoid tissue CD103+ DCs
Ginhoux, F., Liu, K., Helft, J., Bogunovic, M., Greter, M., Hashimoto, D., Price, J. G., Yin, N., Bromberg, J. S., Lira, S. A., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091756 · Cited by 744 · see citing works
Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis
Tabas, I. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184783.04864.9f · Cited by 641 · see citing works
Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage–Derived VEGFA
Harney, A. S., Arwert, E. N., Entenberg, D. R., Wang, Y., Guo, P., Qian, B., Oktay, M. H., Pollard, J. W., Jones, J. G., & Condeelis, J. S. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0012 · Cited by 622 · see citing works
YERSINIA OUTER PROTEINS: Role in Modulation of Host Cell Signaling Responses and Pathogenesis
Viboud, G. I., & Bliska, J. B. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121320 · Cited by 600 · see citing works
A timeline of tumour-associated macrophage biology
Cassetta, L., & Pollard, J. W. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-022-00547-1 · Cited by 601 · see citing works
Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain
Guan, Z., Kuhn, J., Wang, X., Colquitt, B. M., Solórzano, C., Vaman, S., Guan, A. K., Evans-Reinsch, Z., Braz, J. M., Devor, M. G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4189 · Cited by 554 · see citing works
Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain
Yu, X., Liu, H., Hamel, K. A., Morvan, M. G., Yu, S. W., Leff, J., Guan, Z., Braz, J. M., & Basbaum, A. I. (2020) · Nature Communications · doi:10.1038/s41467-019-13839-2 · Cited by 508 · see citing works
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model
Alexander, K. A., Chang, M. K., Maylin, E. R., Kohler, T., Müller, R., Wu, A. C., Van Rooijen, N., Sweet, M. J., Hume, D. A., Raggatt, L. J., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.354 · Cited by 485 · see citing works
Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection
Blériot, C., Dupuis, T., Jouvion, G., Eberl, G., Disson, O., & Lecuit, M. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.020 · Cited by 471 · see citing works
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
Ishii, M., Egen, J. G., Klauschen, F., Meier-Schellersheim, M., Saeki, Y., Vacher, J., Proia, R. L., & Germain, R. N. (2009) · Nature · doi:10.1038/nature07713 · Cited by 515 · see citing works
Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer
Pan, P., Ma, G., Weber, K. J., Ozao‐Choy, J. J., Wang, G., Yin, B., Divino, C. M., & Chen, S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1882 · Cited by 467 · see citing works
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
McDonald, M. M., Khoo, W. H., Ng, P. Y., Xiao, Y., Zamerli, J., Thatcher, P., Kyaw, W., Pathmanandavel, K., Grootveld, A. K., Moran, I., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.002 · Cited by 433 · see citing works
The multifaceted roles of macrophages in bone regeneration: A story of polarization, activation and time
Schlundt, C., Fischer, H., Bucher, C. H., Rendenbach, C., Duda, G. N., & Schmidt-Bleek, K. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.052 · Cited by 415 · see citing works
Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen
Lim, H. Y., Lim, S. Y., Tan, C. K., Thiam, C. H., Goh, C. C., Carbajo, D., Chew, S. H. S., See, P., Chakarov, S., Wang, X. N., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.06.008 · Cited by 384 · see citing works
Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System
Chiţu, V., Gökhan, Ş., Nandi, S., Mehler, M. F., & Stanley, E. R. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.03.005 · Cited by 354 · see citing works
Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy
Priceman, S. J., Sung, J. L., Shaposhnik, Z., Burton, J. B., Torres‐Collado, A. X., Moughon, D. L., Johnson, M., Lusis, A. J., Cohen, D. A., Iruela‐Arispe, M. L., et al. (2009) · Blood · doi:10.1182/blood-2009-08-237412 · Cited by 357 · see citing works
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Whitaker, R. C., Hernaez‐Estrada, B., Hernández, R. M., Santos‐Vizcaíno, E., & Spiller, K. L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00895 · Cited by 345 · see citing works
Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis
Vi, L., Baht, G. S., Whetstone, H., Ng, A., Wei, Q., Poon, R., Mylvaganam, S., Grynpas, M., & Alman, B. A. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2422 · Cited by 330 · see citing works
The role of macrophages in osteoarthritis and cartilage repair
Wu, C., Harasymowicz, N. S., Klimak, M., Collins, K. H., & Guilak, F. (2020) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.12.007 · Cited by 328 · see citing works
OsteoMacs: Key players around bone biomaterials.
Miron, R., & Bosshardt, D. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.017 · Cited by 295 · see citing works
Studying the mononuclear phagocyte system in the molecular age
Chow, A. T., Brown, B. D., & Mérad, M. (2011) · Nature reviews. Immunology · doi:10.1038/nri3087 · Cited by 315 · see citing works
Macrophages: Their Emerging Roles in Bone
Sinder, B. P., Pettit, A. R., & McCauley, L. K. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2735 · Cited by 301 · see citing works
Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
Luo, J., Elwood, F., Britschgi, M., Villeda, S., Zhang, H., Ding, Z., Zhu, L., Alabsi, H., Getachew, R., Narasimhan, R., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20120412 · Cited by 262 · see citing works
Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification.
Raggatt, L., Wullschleger, M., Alexander, K. A., Wu, A., Millard, S., Kaur, S., Maugham, M. L., Gregory, L. S., Steck, R., & Pettit, A. (2014) · American Journal of Pathology · doi:10.1016/j.ajpath.2014.08.017 · Cited by 269 · see citing works
Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology
Armiento, A. R., Hatt, L. P., Rosenberg, G. S., Thompson, K., & Stoddart, M. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909874 · Cited by 275 · see citing works
Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy
Cersosimo, F., Lonardi, S., Bernardini, G., Telfer, B., Mandelli, G. E., Santucci, A., Vermi, W., & Giurisato, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155207 · Cited by 280 · see citing works
Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice
Yang, L., Kwon, J., Popov, Y., Gajdos, G., Ordog, T., Brekken, R., Mukhopadhyay, D., Schuppan, D., Bi, Y., Simonetto, D., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.061 · Cited by 234 · see citing works
Conditional Macrophage Ablation Demonstrates That Resident Macrophages Initiate Acute Peritoneal Inflammation
Cailhier, J. F., Partolina, M., Vuthoori, S., Wu, S., Ko, K. A., Watson, S. J., Savill, J., Hughes, J., & Lang, R. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2336 · Cited by 244 · see citing works
Regulation of Bone Remodeling by Parathyroid HormonePreprint
Wein, M. N., & Kronenberg, H. M. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031237 · Cited by 243 · see citing works
Suppression of experimental colitis by intestinal mononuclear phagocytes
Qualls, J. E., Kaplan, A. M., van Rooijen, N., & Cohen, D. A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205734 · Cited by 237 · see citing works
Self-citation
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III
Chang, C.-L., Weigel, A. V., Ioannou, M. S., Pasolli, H. A., Xu, C. S., Peale, D. R., Shtengel, G., Freeman, M., Hess, H. F., Blackstone, C., et al. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201902061 · Cited by 206 · see citing works
Simultaneous intravital imaging of macrophage and neutrophil behaviour during inflammation using a novel transgenic zebrafish
Gray, C., Loynes, C. A., Whyte, M. K. B., Crossman, D. C., Renshaw, S. A., & Chico, T. (2011) · Thrombosis and Haemostasis · doi:10.1160/th10-08-0525 · Cited by 204 · see citing works
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice
Garcia, M. R., Ledgerwood, L. G., Yang, Y., Xu, J., Lal, G., Burrell, B. E., Ma, G., Hashimoto, D., Li, Y., Boros, P., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41628 · Cited by 204 · see citing works
Osteal macrophages: A new twist on coupling during bone dynamics
Pettit, A. R., Chang, M. K., Hume, D. A., & Raggatt, L. J. (2008) · Bone · doi:10.1016/j.bone.2008.08.128 · Cited by 195 · see citing works
CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair
Batoon, L., Millard, S. M., Wullschleger, M., Preda, C., Wu, A., Kaur, S., Tseng, H., Hume, D. A., Lévesque, J.-P., Raggatt, L. J., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.033 · Cited by 197 · see citing works
Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche
Chakrabarti, R., Celià-Terrassa, T., Kumar, S., Hang, X., Wei, Y., Choudhury, A., Hwang, J., Peng, J., Nixon, B. G., Grady, J. J., et al. (2018) · Science · doi:10.1126/science.aan4153 · Cited by 196 · see citing works
Tumor Necrosis Factor-α Accelerates the Resolution of Established Pulmonary Fibrosis in Mice by Targeting Profibrotic Lung Macrophages
Redente, E. F., Keith, R. C., Janssen, W., Henson, P. M., Ortiz, L. A., Downey, G. P., Bratton, D. L., & Riches, D. W. H. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0386oc · Cited by 195 · see citing works
The mechanism of anti-CD20–mediated B cell depletion revealed by intravital imaging
Montalvão, F., Garcia, Z., Celli, S., Bréart, B., Deguine, J., van Rooijen, N., & Bousso, P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70972 · Cited by 192 · see citing works
Osteoarthritis year in review 2020: biology
van den Bosch, M. H. J. (2020) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2020.10.006 · Cited by 191 · see citing works
Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone
Cho, S. W., Soki, F. N., Koh, A. J., Eber, M. R., Entezami, P., Park, S. I., van Rooijen, N., & McCauley, L. K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315153111 · Cited by 191 · see citing works
Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion
Youssef, L. A., Rebbaa, A., Pampou, S., Weisberg, S. P., Stockwell, B. R., Hod, E. A., & Spitalnik, S. L. (2018) · Blood · doi:10.1182/blood-2017-12-822619 · Cited by 186 · see citing works
DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance
Condé, P., Rodríguez, M., van der Touw, W., Jimenez, A., Burns, M., Miller, J. C., Brahmachary, M., Chen, H.-M., Boros, P., Rausell-Palamos, F., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.009 · Cited by 188 · see citing works
Self-citation
Distinct Roles for Dectin-1 and TLR4 in the Pathogenesis of Aspergillus fumigatus Keratitis
Leal, S. M., Cowden, S., Hsia, Y. C., Ghannoum, M. A., Momany, M., & Pearlman, E. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000976 · Cited by 179 · see citing works
Paired Immunoglobin-like Receptor-B Regulates the Suppressive Function and Fate of Myeloid-Derived Suppressor Cells
Ma, G., Pan, P., Eisenstein, S. G., Divino, C. M., Lowell, C. A., Takai, T., & Chen, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.004 · Cited by 175 · see citing works
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation
Hashimoto, D., Chow, A. T., Greter, M., Saenger, Y. M., Kwan, W.-H., Leboeuf, M., Ginhoux, F., Ochando, J., Kunisaki, Y., van Rooijen, N., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101709 · Cited by 172 · see citing works
The Basic Immune Simulator: An agent-based model to study the interactions between innate and adaptive immunity
Folcik, V. A., An, G. C., & Orosz, C. G. (2007) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-4-39 · Cited by 174 · see citing works
Macrophages and skeletal health
Michalski, M. N., & McCauley, L. K. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.017 · Cited by 172 · see citing works
Wnt signaling modulates macrophage polarization and is regulated by biomaterial surface properties
Abaricia, J. O., Shah, A. H., Chaubal, M., Hotchkiss, K. M., & Olivares‐Navarrete, R. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119920 · Cited by 173 · see citing works
Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution
O’Brien, J., Martinson, H. A., Durand‐Rougely, C., & Schedin, P. S. (2011) · Development · doi:10.1242/dev.071696 · Cited by 163 · see citing works
Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases
Patel, S. K., & Janjic, J. M. (2014) · Theranostics · doi:10.7150/thno.9476 · Cited by 153 · see citing works
Brain microvessel cross‐presentation is a hallmark of experimental cerebral malaria
Howland, S. W., Poh, C. M., Gun, S. Y., Claser, C., Malleret, B., Shastri, N., Ginhoux, F., Grotenbreg, G. M., & Rénia, L. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202273 · Cited by 150 · see citing works
Managing Macrophages in Rheumatoid Arthritis by Reform or Removal
Li, ., Hsu, H., & Mountz, J. D. (2012) · Current Rheumatology Reports · doi:10.1007/s11926-012-0272-4 · Cited by 149 · see citing works
Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas‐Induced Apoptosis–Transgenic Mice
Wu, C., McNeill, J. N., Goon, K. C., Little, D., Kimmerling, K. A., Huebner, J. L., Kraus, V. B., & Guilak, F. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40161 · Cited by 147 · see citing works
CD8+ T Cells and IFN-γ Mediate the Time-Dependent Accumulation of Infected Red Blood Cells in Deep Organs during Experimental Cerebral Malaria
Claser, C., Malleret, B., Gun, S. Y., Wong, A. Y. W., Chang, Z. W., Teo, P., See, P., Howland, S. W., Ginhoux, F., & Rénia, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018720 · Cited by 143 · see citing works
Applications of myeloid‐specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity
Hume, D. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0810472 · Cited by 154 · see citing works
Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice
Vi, L., Baht, G. S., Soderblom, E. J., Whetstone, H., Wei, Q., Furman, B., Puviindran, V., Nadesan, P., Foster, M., Poon, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07666-0 · Cited by 140 · see citing works
Erythro-myeloid progenitors contribute endothelial cells to blood vessels
Plein, A., Fantin, A., Denti, L., Pollard, J. W., & Ruhrberg, C. (2018) · Nature · doi:10.1038/s41586-018-0552-x · Cited by 139 · see citing works
Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D
Kikuta, J., Kawamura, S., Okiji, F., Shirazaki, M., Sakai, S., Saitô, H., & Ishii, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218799110 · Cited by 138 · see citing works
Collagen Membrane and Immune Response in Guided Bone Regeneration: Recent Progress and Perspectives
Chu, C.-Y., Deng, J., Sun, X.-C., Qu, Y.-L., & Man, Y. (2017) · Tissue engineering. Part B, Reviews · doi:10.1089/ten.teb.2016.0463 · Cited by 129 · see citing works
TLR4 and TLR5 on Corneal Macrophages Regulate Pseudomonas aeruginosa Keratitis by Signaling through MyD88-Dependent and -Independent Pathways
Sun, Y., Karmakar, M., Roy, S., Ramadan, R. T., Williams, S. R., Howell, S. J., Shive, C. L., Han, Y. W., Stopford, C. M., Rietsch, A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000874 · Cited by 137 · see citing works
Genetic Ablation of Drosophila Phagocytes Reveals Their Contribution to Both Development and Resistance to Bacterial Infection
Defaye, A., Evans, I. R., Crozatier, M., Wood, W., Lemaître, B., & Leulier, F. (2009) · Journal of Innate Immunity · doi:10.1159/000210264 · Cited by 136 · see citing works
Osteoinduction and osteoimmunology: Emerging concepts
Miron, R. J., Bohner, M., Zhang, Y., & Bosshardt, D. D. (2023) · Periodontology 2000 · doi:10.1111/prd.12519 · Cited by 135 · see citing works
KIT oncogene inhibition drives intratumoral macrophage M2 polarization
Cavnar, M. J., Zeng, S., Kim, T. S., Sorenson, E. C., Ocuin, L. M., Balachandran, V. P., Seifert, A. M., Greer, J. B., Popow, R., Crawley, M. H., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130875 · Cited by 134 · see citing works
Phenotypic impacts of CSF1R deficiencies in humans and model organisms
Hume, D. A., Caruso, M., Ferrari-Cestari, M., SUMMERS, K. M., Pridans, C., & Irvine, K. M. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr0519-143r · Cited by 121 · see citing works
Macrophages in the embryo and beyond: Much more than just giant phagocytes
Ovchinnikov, D. A. (2008) · genesis · doi:10.1002/dvg.20417 · Cited by 127 · see citing works
Macrophage angiotensin II type 2 receptor triggers neuropathic pain
Shepherd, A. J., Mickle, A. D., Golden, J. P., Mack, M. R., Halabi, C. M., de Kloet, A. D., Samineni, V. K., Kim, B., Krause, E. G., Gereau, R. W., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721815115 · Cited by 126 · see citing works
Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.
Dhaliwal, K., Scholefield, E., Ferenbach, D., Gibbons, M., Duffin, R., Dorward, D., Morris, A., Humphries, D. C., Mackinnon, A., Wilkinson, T., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201112-2132oc · Cited by 134 · see citing works
IL-10 Immunomodulation of Myeloid Cells Regulates a Murine Model of Ovarian Cancer
Hart, K. M., Byrne, K. T., Molloy, M. J., Usherwood, E. M., & Berwin, B. L. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00029 · Cited by 122 · see citing works
Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches
Kaur, S., Raggatt, L. J., Batoon, L., Hume, D. A., Lévesque, J.-P., & Pettit, A. R. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.009 · Cited by 118 · see citing works
Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing
Gay, D., Ghinatti, G., Guerrero-Juarez, C., Ferrer, R. A., Ferri, F., Lim, C., Murakami, S., Gault, N., Barroca, V., Rombeau, I., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay3704 · Cited by 95 · see citing works
Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression
Galletti, G., Scielzo, C., Barbaglio, F., Rodríguez, T. V., Riba, M., Lazarević, D., Cittaro, D., Simonetti, G., Ranghetti, P., Scarfò, L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.042 · Cited by 114 · see citing works
Comparison of the lateral tail vein and the retro-orbital venous sinus as routes of intravenous drug delivery in a transgenic mouse model
Steel, C., Stephens, A. L., Hahto, S. M., Singletary, S. J., & Ciavarra, R. P. (2007) · Lab Animal · doi:10.1038/laban0108-26 · Cited by 113 · see citing works
Oligodendrocyte-Specific Activation of PERK Signaling Protects Mice against Experimental Autoimmune Encephalomyelitis
Lin, W., Lin, Y., Li, J., Fenstermaker, A. G., Way, S. W., Clayton, B. L. L., Jamison, S., Harding, H. P., Ron, D., & Popko, B. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1636-12.2013 · Cited by 113 · see citing works
Homing and Adhesion Patterns Determine the Cellular Composition of the Bone Marrow Plasma Cell Niche
Belnoue, E., Tougne, C., Rochat, A., Lambert, P., Pinschewer, D. D., & Siegrist, C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103169 · Cited by 113 · see citing works
Giant cells around bone biomaterials: Osteoclasts or multi-nucleated giant cells?
Miron, R., Zohdi, H., Fujioka-Kobayashi, M., & Bosshardt, D. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.09.029 · Cited by 108 · see citing works
Molecular Neuroanatomy's “Three Gs”: A Primer
Dymecki, S. M., & Kim, J. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.009 · Cited by 110 · see citing works
The Components of Bone and What They Can Teach Us about Regeneration
Le, B. Q., Nurcombe, V., Cool, S. M., van Blitterswijk, C., de Boer, J., & LaPointe, V. L. S. (2017) · Materials · doi:10.3390/ma11010014 · Cited by 105 · see citing works
Macrophage immunomodulation in chronic osteolytic diseases—the case of periodontitis
Sima, C., Viniegra, A., & Glogauer, M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ru0818-310r · Cited by 106 · see citing works
Targeting Myelomonocytic Cells to Revert Inflammation-Dependent Cancer Promotion
Colombo, M. P., & Mantovani, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2714 · Cited by 103 · see citing works
ExoS and ExoT ADP Ribosyltransferase Activities Mediate Pseudomonas aeruginosa Keratitis by Promoting Neutrophil Apoptosis and Bacterial Survival
Sun, Y., Karmakar, M., Taylor, P. R., Rietsch, A., & Pearlman, E. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102148 · Cited by 102 · see citing works
Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages
Bain, C. C., Gibson, D. A., Steers, N. J., Boufea, K., Louwe, P. A., Doherty, C., González-Huici, V., Gentek, R., Magalhaes-Pinto, M., Shaw, T., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abc4466 · Cited by 97 · see citing works
PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2
Aikawa, Y., Katsumoto, T., Zhang, P., Shima, H., Shino, M., Terui, K., Ito, E., Ohno, H., Stanley, E. R., Singh, H., et al. (2010) · Nature Medicine · doi:10.1038/nm.2122 · Cited by 96 · see citing works
Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial Infarction
Leblond, A., Klinkert, K., Martin, K., Turner, E. C., Kumar, A. H. S., Browne, T. C., & Caplice, N. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137515 · Cited by 98 · see citing works
Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression
Bąk, S., Alonso, A., Turk, M. J., & Berwin, B. L. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.08.266 · Cited by 95 · see citing works
Monocytes control natural killer cell differentiation to effector phenotypes
Soderquest, K., Powell, N., Luci, C., van Rooijen, N., Hidalgo, A., Geissmann, F., Walzer, T., Lord, G. M., & Martin‐Fontecha, A. (2011) · Blood · doi:10.1182/blood-2010-10-312264 · Cited by 93 · see citing works
Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation
Pinto, A. R., Godwin, J. W., & Rosenthal, N. A. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.06.004 · Cited by 90 · see citing works
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation
Markey, K. A., Banovic, T., Kuns, R. D., Olver, S. D., Don, A. L. J., Raffelt, N. C., Wilson, Y. A., Raggatt, L. J., Pettit, A. R., Bromberg, J. S., et al. (2009) · Blood · doi:10.1182/blood-2008-12-191833 · Cited by 89 · see citing works
Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia
Kalymbetova, T., Selvakumar, B., Rodríguez-Castillo, J. A., Gunjak, M., Malainou, C., Heindl, M. R., Moiseenko, A., Chao, C.-M., Vadász, I., Mayer, K., et al. (2018) · Journal of Pathology · doi:10.1002/path.5076 · Cited by 78 · see citing works
The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1
Shutov, L. P., Warwick, C. A., Shi, X., Gnanasekaran, A., Shepherd, A. J., Mohapatra, D. P., Woodruff, T. M., Clark, J. D., & Usachev, Y. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3249-15.2016 · Cited by 85 · see citing works
High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice
Chèvre, R., González, J. M., Megens, R. T. A., Sreeramkumar, V., Silvestre-Roig, C., Molina-Sánchez, P., Weber, C., Soehnlein, O., Hidalgo, A., & Andrés, V. (2013) · Circulation Research · doi:10.1161/circresaha.114.302590 · Cited by 83 · see citing works
Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain
Logu, F. D., Marini, M., Landini, L., de Araújo, D. S. M., Bartalucci, N., Trevisan, G., Bruno, G., Marangoni, M., Schmidt, B. L., Bunnett, N. W., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3326 · Cited by 83 · see citing works
Osteoimmunology of Fracture Healing.
Molitoris, K. H., Huang, M., & Baht, G. S. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00869-z · Cited by 84 · see citing works
“BM MΦs play a critical role in bone repair: ablation of macrophages is associated with decreased bone deposition within the fracture callus and higher rates of non-union [13, 14, 24].”
Background

Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide
Burnett, R. H., Kershen, E. J., Zhang, J., Zeng, L., Straley, S. C., Kaplan, A. M., & Cohen, D. A. (2004)
Self-citation
Generation of a novel mouse model for the inducible depletion of macrophages in vivo
Gheryani, N. A., Coffelt, S. B., Gartland, A., Rumney, R. M. H., Kiss‐Toth, E., Lewis, C. E., Tozer, G. M., Greaves, D. R., Dear, T. N., & Miller, G. (2012) · genesis · doi:10.1002/dvg.22343 · Cited by 9 · see citing works
Inducible transgenes under the control of the hCD68 promoter identifies mouse macrophages with a distribution that differs from the F4/80 - and CSF-1R–expressing populations
Pillai, M. M., Hayes, B. J., & Torok‐Storb, B. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.09.003 · Cited by 29 · see citing works
Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage
Lang, R. A., Metcalf, D., Cuthbertson, R. A., Lyons, I. G., Stanley, E. G., Kelso, A., Kannourakis, G., Williamson, D. J., Klintworth, G. K., Gonda, T. J., et al. (1987) · Cell · doi:10.1016/0092-8674(87)90136-x · Cited by 366 · see citing works
Autocrine Deactivation of Macrophages in Transgenic Mice
Promoter, H. C., Lang, R., Erlangen, U., Profile, S., Greaves, D. R., Murray, P. J., & Promoter, H. C. (2002)

Authors: Burnett, S. H., Kershen, E. J., Zhang, J., Zeng, L., Straley, S. C., Kaplan, A. M., & Cohen, D. A.
Affiliations: University of Kentucky (US)
Corresponding author: Cohen, Donald A
ORCID: Zhang, Jiayou
Zeng, Li
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2004-01-14
Volume: 75
Issue: 4
Pages: 612-623
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.0903442
OpenAlex: W2163279811
Cited by: 307
References: 44
Citations by year: 2026: 7 · 2025: 10 · 2024: 21 · 2023: 17 · 2022: 15 · 2021: 17 · 2020: 18 · 2019: 12 · 2018: 17 · 2017: 20 · 2016: 13 · 2015: 22 · 2014: 21 · 2013: 18 · 2012: 11
FWCI: 3.20
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Funders: NIH (HL69459, HL57399, 5T32AI049795)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: macrophage depletion, dendritic cells, bacterial clearance, splenomegaly, lymphadenopathy, thymic atrophy, extramedullary hematopoiesis, peritoneal adhesions, transgenic mice
MeSH terms: Animals, Bacterial Infections, Cell Count, Cells, Cultured, Dendritic Cells, Disease Models, Animal, Immunity, Cellular, Luminescent Proteins, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Promoter Regions, Genetic, Receptor, Macrophage Colony-Stimulating Factor, Tacrolimus, Apoptosis, Receptors, Nerve Growth Factor, fas Receptor, Dimerization, Tacrolimus Binding Proteins, Genes, Transgenic, Suicide, Green Fluorescent Proteins, Mice

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Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene

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