The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
VEGF ‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart
Open accessAbstract
Angiogenic growth factors have recently been linked to tissue metabolism. We have used genetic gain- and loss-of function models to elucidate the effects and mechanisms of action of vascular endothelial growth factor-B (VEGF-B) in the heart. A cardiomyocyte-specific VEGF-B transgene induced an expanded coronary arterial tree and reprogramming of cardiomyocyte metabolism. This was associated with protection against myocardial infarction and preservation of mitochondrial complex I function upon ischemia-reperfusion. VEGF-B increased VEGF signals via VEGF receptor-2 to activate Erk1/2, which resulted in vascular growth. Akt and mTORC1 pathways were upregulated and AMPK downregulated, readjusting cardiomyocyte metabolic pathways to favor glucose oxidation and macromolecular biosynthesis. However, contrasting with a previous theory, there was no difference in fatty acid uptake by the heart between the VEGF-B transgenic, gene-targeted or wildtype rats. Importantly, we also show that VEGF-B expression is reduced in human heart disease. Our data indicate that VEGF-B could be used to increase the coronary vasculature and to reprogram myocardial metabolism to improve cardiac function in ischemic heart disease.
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Cites
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature · doi:10.1038/nature06613 · Cited by 1,054
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Vascular heterogeneity and specialization in development and disease
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Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2018) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 572
Lee, C., Kim, M.-J., Kumar, A., Lee, H.-W., Yang, Y., & Kim, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02249-0 · Cited by 365
Lacteal junction zippering protects against diet-induced obesity
Zhang, F., Zarkada, G., Han, J., Li, J., Dubrac, A., Ola, R., Genet, G., Boyé, K., Michon, P., Künzel, S. E., et al. (2018) · Science · doi:10.1126/science.aap9331 · Cited by 237
Self-citationEndothelial cell metabolism in cardiovascular physiology and disease
Pasut, A., Lama, E., Van Craenenbroeck, A. H., Kroon, J., & Carmeliet, P. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01162-x · Cited by 74
Metadata
- Authors
- Kivelä, R., Bry, M., Robciuc, M. R., Räsänen, M., Taavitsainen, M., Silvola, J. M., Saraste, A., Hulmi, J. J., Anisimov, A., Mäyränpää, M. I., Lindeman, J. H., Eklund, L., Hellberg, S., Hlushchuk, R., Zhuang, Z. W., Simons, M., Djonov, V., Knuuti, J., Mervaala, E., & Alitalo, K.
- Venue
- EMBO Molecular Medicine
- Published
- 2014-01-21
- Volume
- 6
- Issue
- 3
- Pages
- 307-321
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- OpenAlex
- W2111094676
- Cited by
- 170
- References
- 1
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Kivelä, R., Bry, M., Robciuc, M. R., Räsänen, M., Taavitsainen, M., Silvola, J. M., Saraste, A., Hulmi, J. J., Anisimov, A., Mäyränpää, M. I., Lindeman, J. H., Eklund, L., Hellberg, S., Hlushchuk, R., Zhuang, Z. W., Simons, M., Djonov, V., Knuuti, J., Mervaala, E., & Alitalo, K. (2014). VEGF ‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Molecular Medicine. https://doi.org/10.1002/emmm.201303147
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
