Is there a basis for a weight cut‐off point? A large‐scale investigation of atypical anorexia and anorexia nervosa subtypes among patients at a residential treatment centre.
Open accessAbstract
Objective: There is debate surrounding how to differentiate between anorexia nervosa (AN) and atypical AN (atypAN) as diagnostic entities, and whether a distinction based on BMI is warranted. Better understanding eating disorder (ED) and emotional symptoms across atypAN and AN subtypes [AN‐restricting (AN‐R), AN‐binge/purge (AN‐BP)], with and without controlling for BMI, can elucidate how atypAN differs from AN subtypes and whether there is a basis for a BMI cut‐off. Methods: 1810 female patients at an ED treatment centre completed intake surveys. ANCOVAs assessed differences across AN‐R (n = 853), AN‐BP (n = 726), and atypAN (n = 231) groups on ED, depressive, and anxiety symptoms, anxiety sensitivity, experiential avoidance, and mindfulness, with and without controlling for BMI. Results: Relative to AN‐R, atypAN and AN‐BP groups endorsed significantly higher ED and depressive symptoms, anxiety sensitivity, experiential avoidance, and significantly lower mindfulness (all p < 0.001), but atypAN and AN‐BP groups did not differ from one another. When controlling for BMI, all previously significant differences between atypAN and AN‐R did not remain significant. Conclusion: Individuals with atypAN who have a higher BMI experience more pronounced ED and emotional symptoms, suggesting that relying solely on BMI as a marker of illness severity may be problematic. Highlights: Atypical anorexia nervosa (atypAN) describes individuals who meet all of the criteria for AN, but who, despite significant weight loss, have a BMI within or above the 'normal' weight range.Individuals with atypAN endorsed more severe eating disorder and emotional symptoms than individuals with AN‐restricting subtype, and the higher BMI of individuals with atypAN accounted for these differences.atypAN symptoms may not only be just as severe as those of AN despite their higher weight, but may be exacerbated by weight stigma and greater body image concerns because of their higher weight.
AI snapshot
Written from the paper’s full text.
TL;DR
This study compared eating-disorder and emotional symptoms among female residential patients with atypical anorexia nervosa (atypAN), anorexia nervosa restricting subtype (AN-R), and anorexia nervosa binge/purge subtype (AN-BP), with and without adjusting for BMI. It found that atypAN and AN-BP patients reported more severe symptoms than AN-R patients, but most atypAN–AN-R differences disappeared after controlling for BMI, raising questions about using BMI alone to define illness severity.
Key findings
- Among 1,810 female patients, AN-R made up 21.0% of admissions (n = 853), AN-BP 17.9% (n = 726), and atypAN 5.7% (n = 231); mean BMIs were 17.08 for AN-R, 18.15 for AN-BP, and 21.62 for atypAN.
- With duration of illness controlled, atypAN and AN-BP groups had significantly higher EDE-Q global scores (4.28 and 4.27 vs. 3.61), depressive symptoms (39.43 and 39.24 vs. 35.64), anxiety sensitivity (34.46 and 32.22 vs. 30.25), and experiential avoidance (60.03 and 59.85 vs. 56.08), and significantly lower mindfulness (29.88 and 30.43 vs. 33.53) than AN-R, all p < 0.001; atypAN and AN-BP did not differ from each other.
- After BMI was added as a covariate, atypAN–AN-R differences were no longer significant, while AN-BP–AN-R differences largely remained; AN-BP then showed significantly greater EDE-Q global scores than atypAN (4.26 vs. 3.91). Effect sizes were small.
- Exploratory analyses splitting atypAN into binge/purge (n = 145) and restricting (n = 80) groups found the same pattern as AN subtypes: atypAN-BP reported higher eating-disorder psychopathology, depression, and experiential avoidance, and lower mindfulness, than atypAN-R.
Methods
- Female patients at a residential eating-disorder treatment centre completed intake self-report questionnaires; data came from two sites between 2014 and 2020, representing about 85% of admissions, with a final sample of 1,810 patients diagnosed with AN or atypAN.
- Diagnoses were established through pre-admission structured phone assessments and post-admission semi-structured psychiatric interviews using DSM-5 criteria; BMI was measured at intake with an electronic scale and stadiometer.
- ANCOVAs compared AN-R, AN-BP, and atypAN groups on EDE-Q, CES-D, OASIS, ASI, BEAQ, and SMQ scores, first controlling for duration of illness and then adding BMI; Sidak post-hoc tests were used, and exploratory t-tests compared atypAN subtypes.
Limitations
- The paper states that diagnostic procedures were unclear, including how “significant weight loss” was operationalised, how lack of recognition of seriousness was handled when weight was not low, and whether strict BMI cut-offs were used.
- The paper states that the sample was mostly white females, that residential treatment may be less accessible to people without financial resources or insurance, and that a referral bias may have made the atypAN patients more symptomatic than atypAN patients not seeking treatment or AN-R patients admitted because of low BMI.
- Evident from the text: the design is cross-sectional and self-report, so causal claims cannot be made; the paper also notes that all effect sizes were small, limiting clinical relevance, and the residential sample is not an epidemiological sample, limiting generalisability.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
4 of 16 cited sources checked · 0 supported · 0 flagged · accuracy not yet measured
- Interpretationcitation
AtypAN may be more difficult to detect than AN due to a lack of apparent emaciation, particularly in an environment where weight loss behaviours such as dieting and exercise are culturally normative.
“AtypAN may be more difficult to detect than AN due to a lack of apparent emaciation, particularly in an environment where weight loss behaviours such as dieting and exercise are culturally normative (Reba-Harrelson et al., 2009).”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Reba-Harrelson et al., 2009 source
The Discussion reports that dieting and attempts to lose weight were common among the women surveyed, supporting the background point about prevalent weight-loss behaviours. It does not address atypical anorexia nervosa or say that a lack of apparent emaciation makes it harder to detect than anorexia nervosa. (LLM, conf=0.85)
Experimental — accuracy not yet measured
- Premisecitation
Epidemiological studies have indicated significantly higher prevalence rates of atypAN compared with AN.
“Epidemiological studies have indicated significantly higher prevalence rates of atypAN compared with AN (Harrop et al., 2021)”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Harrop et al., 2021 source
The Results section on epidemiological prevalence says atypical anorexia nervosa (AAN) point prevalence met or exceeded anorexia nervosa (AN) prevalence in most studies comparing both disorders. It does not establish that AAN prevalence was significantly higher: some point-prevalence rates were equal or lower, and half the studies comparing lifetime prevalence found AN higher. (LLM, conf=0.85)
Experimental — accuracy not yet measured
- Premisecitation
AN recovery is much more successful when treated early.
“Given that AN recovery is much more successful when treated early (Ambwani et al., 2020)”
Quote in the paperSubstantial claim1 of 1 sources checked- cites Ambwani et al., 2020 source
The introduction (p. 8) says research suggests early intervention produces good outcomes and people with enduring illness respond less well. The exploratory results (p. 17) find less improvement on some measures in the severe-and-enduring group, but they do not establish that treating AN early makes recovery much more successful; the reported recovery rate is for the full cohort (p. 16). (LLM, conf=0.87)
Experimental — accuracy not yet measured
- Findingown data
When controlling for BMI, differences between AN-R and AN-BP for anxiety sensitivity did not remain significant.
“When controlling for BMI, differences between AN-R and atypAN for anxiety sensitivity remained significant, but differences between AN-R and AN-BP did not.”
Quote in the paperNot a substantial claim - Findingown data
When controlling for BMI, atypAN did not significantly differ from AN-R or AN-BP on anxiety symptoms, depressive symptoms, experiential avoidance, and mindfulness.
“AtypAN did not significantly differ from AN-R or AN-BP on these measures.”
Quote in the paperSubstantial claim
- Findingown data
Effect sizes for all analyses conducted were small.
“Effect sizes for all analyses conducted were small (Tables 2 and 3).”
Quote in the paperNot a substantial claim - Findingown data
Relative to AN-R, atypAN and AN-BP groups reported significantly greater ED symptoms (EDE-Q global) when controlling for ED duration.
“Post-hoc tests found that relative to the AN-R group, atypAN and AN-BP groups reported significantly greater ED symptoms, depressive symptoms, anxiety sensitivity, experiential avoidance, and significantly lower mindfulness than AN-R (Supplemental Table 2).”
Quote in the paperSubstantial claim - Findingown data
In exploratory analyses, individuals with atypAN-BP endorsed significantly higher depression than those with atypAN-R.
“individuals with atypAN-BP endorsed significantly higher ED psychopathology, depression, and experiential avoidance, and significantly lower mindfulness, than those with atypAN-R (Supplemental Table 4).”
Quote in the paperNot a substantial claim - Findingown data
AtypAN and AN-BP groups did not significantly differ from one another on ED symptoms, depressive symptoms, anxiety sensitivity, experiential avoidance, and mindfulness when controlling for ED duration.
“AtypAN and AN-BP did not significantly differ from one another on these measures (Supplemental Table 2).”
Quote in the paperSubstantial claim - Findingown data
Individuals with AN-BP reported significantly more binge eating than individuals with atypAN and AN-R.
“Individuals with AN-BP reported significantly more binge eating than individuals with atypAN and AN-R.”
Quote in the paperNot a substantial claim - Findingnone given
The average BMI in the atypAN group was 21.6.
“given that the average BMI in the atypAN group was 21.6 and not on average 'higher weight'.”
Quote in the paperSubstantial claim - Findingown data
When controlling for BMI, differences between AN-R and atypAN for anxiety sensitivity remained significant.
“When controlling for BMI, differences between AN-R and atypAN for anxiety sensitivity remained significant, but differences between AN-R and AN-BP did not.”
Quote in the paperSubstantial claim - Findingown data
When controlling for BMI, differences between AN-R and AN-BP on mindfulness remained significant.
“When BMI was controlled, differences between AN-R and AN-BP groups on anxiety symptoms, depression symptoms, experiential avoidance, and mindfulness remained significant, such that those with AN-BP endorsed greater anxiety, depressive, and experiential avoidance symptoms than AN-R (Supplemental Table 3).”
Quote in the paperNot a substantial claim - Findingown data
In exploratory analyses, individuals with atypAN-BP endorsed significantly lower mindfulness than those with atypAN-R.
“individuals with atypAN-BP endorsed significantly higher ED psychopathology, depression, and experiential avoidance, and significantly lower mindfulness, than those with atypAN-R (Supplemental Table 4).”
Quote in the paperNot a substantial claim - Findingown data
Relative to AN-R, atypAN and AN-BP groups reported significantly greater experiential avoidance (BEAQ) when controlling for ED duration.
“Post-hoc tests found that relative to the AN-R group, atypAN and AN-BP groups reported significantly greater ED symptoms, depressive symptoms, anxiety sensitivity, experiential avoidance, and significantly lower mindfulness than AN-R (Supplemental Table 2).”
Quote in the paperSubstantial claim - Findingown data
In exploratory analyses, individuals with atypAN-BP endorsed significantly higher ED psychopathology than those with atypAN-R.
“individuals with atypAN-BP endorsed significantly higher ED psychopathology, depression, and experiential avoidance, and significantly lower mindfulness, than those with atypAN-R (Supplemental Table 4).”
Quote in the paperNot a substantial claim - Findingown data
Relative to AN-R, atypAN and AN-BP groups reported significantly greater depressive symptoms (CES-D) when controlling for ED duration.
“Post-hoc tests found that relative to the AN-R group, atypAN and AN-BP groups reported significantly greater ED symptoms, depressive symptoms, anxiety sensitivity, experiential avoidance, and significantly lower mindfulness than AN-R (Supplemental Table 2).”
Quote in the paperSubstantial claim - Findingown data
Relative to AN-R, atypAN and AN-BP groups reported significantly lower mindfulness (SMQ) when controlling for ED duration.
“Post-hoc tests found that relative to the AN-R group, atypAN and AN-BP groups reported significantly greater ED symptoms, depressive symptoms, anxiety sensitivity, experiential avoidance, and significantly lower mindfulness than AN-R (Supplemental Table 2).”
Quote in the paperNot a substantial claim - Findingown data
In exploratory analyses, individuals with atypAN-BP endorsed significantly higher experiential avoidance than those with atypAN-R.
“individuals with atypAN-BP endorsed significantly higher ED psychopathology, depression, and experiential avoidance, and significantly lower mindfulness, than those with atypAN-R (Supplemental Table 4).”
Quote in the paperNot a substantial claim - Findingown data
When controlling for BMI in addition to ED duration, ED symptom differences between atypAN and AN-R were no longer significant.
“significant differences between atypAN and AN-R were no longer significant”
Quote in the paperSubstantial claim - Findingown data
Relative to AN-R, atypAN and AN-BP groups reported significantly greater anxiety sensitivity (ASI) when controlling for ED duration.
“Post-hoc tests found that relative to the AN-R group, atypAN and AN-BP groups reported significantly greater ED symptoms, depressive symptoms, anxiety sensitivity, experiential avoidance, and significantly lower mindfulness than AN-R (Supplemental Table 2).”
Quote in the paperNot a substantial claim - Findingown data
After BMI was controlled, atypAN did not differ from AN-R or AN-BP on depressive symptoms.
“After BMI was controlled, atypAN did not differ from AN-R or AN-BP on depressive symptoms.”
Quote in the paperSubstantial claim - Findingown data
In our residential treatment sample, only 5.7% of individuals presented with atypAN relative to AN-R and AN-BP.
“we only had a small percentage of individuals presenting with atypAN (5.7%) relative to AN-R and AN-BP in our residential treatment sample.”
Quote in the paperSubstantial claim - Findingown data
Individuals with atypAN and AN-BP reported significantly higher emotional avoidance than those with AN-R.
“Individuals with atypAN and AN-BP reported significantly higher emotional avoidance and anxiety sensitivity, and significantly lower mindfulness, than those with AN-R”
Quote in the paperSubstantial claim - Findingown data
Individuals with atypAN and AN-BP reported significantly higher anxiety sensitivity than those with AN-R.
“Individuals with atypAN and AN-BP reported significantly higher emotional avoidance and anxiety sensitivity, and significantly lower mindfulness, than those with AN-R”
Quote in the paperSubstantial claim - Findingown data
Individuals with atypAN did not differ from AN-R or AN-BP on anxiety severity.
“and did not differ from AN-R or AN-BP on anxiety severity.”
Quote in the paperNot a substantial claim - Findingown data
When controlling for BMI, the more pathological scores of those with atypAN relative to AN-R disappeared.
“However, when controlling for BMI, the more pathological scores of those with atypAN relative to AN-R disappeared”
Quote in the paperSubstantial claim - Findingown data
Individuals with atypAN and AN-BP reported significantly lower mindfulness than those with AN-R.
“Individuals with atypAN and AN-BP reported significantly higher emotional avoidance and anxiety sensitivity, and significantly lower mindfulness, than those with AN-R”
Quote in the paperSubstantial claim - Findingown data
Individuals with atypAN presented with more severe ED concerns than those with AN in our sample.
“Our results showing that individuals with atypAN presented with more severe ED concerns than those with AN in our sample”
Quote in the paperSubstantial claim - Interpretationown data
The small effect sizes for all differences limit the clinical relevance of these differences.
“Of note, effect sizes for all differences were small, limiting the clinical relevance of these differences.”
Quote in the paperSubstantial claim - Interpretationown data
The higher BMI of those with atypAN may explain the original differences in emotional symptoms between atypAN and AN-R.
“again suggesting that the higher BMI of those with atypAN may explain the original differences”
Quote in the paperSubstantial claim - Premisecitation
Research suggests no relationship between nutritional status and ED psychopathology or psychiatric comorbidities.
“along with research suggesting no relationship between nutritional status and ED psychopathology or psychiatric comorbidities”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Fortunato et al., 2017 source
- Interpretationown data
Binging/purging might contribute to greater psychopathology among those with AN-BP relative to AN-R.
“Our results suggest that both binging/purging and higher BMIs might contribute to greater psychopathology among those with AN-BP and atypAN, respectively, relative to AN-R.”
Quote in the paperSubstantial claim - Interpretationown data
Higher BMIs might contribute to greater psychopathology among those with atypAN relative to AN-R.
“Our results suggest that both binging/purging and higher BMIs might contribute to greater psychopathology among those with AN-BP and atypAN, respectively, relative to AN-R.”
Quote in the paperSubstantial claim - Interpretationcitation
Minimisation and denial of one's ED despite significant ED-related concerns, as well as stigmatising experiences, may lead to elevated emotional difficulties for individuals with atypAN.
“Minimisation and denial of one's ED despite significant ED-related concerns, as well as stigmatising experiences, may lead to elevated emotional difficulties for individuals with atypAN.”
Quote in the paperSubstantial claim - Interpretationown data
The BMI classification criterion does not distinguish the severity of psychopathology.
“Our results suggest that the BMI classification criterion does not distinguish the severity of psychopathology”
- Also stated in: § 4.4 | Limitations and future directions · hedged
“Our results finding more severe ED and emotional symptoms in atypAN compared to AN-R suggest that the BMI classification criterion does not distinguish psychopathological severity.”
Quote in the paperSubstantial claim - Also stated in: § 4.4 | Limitations and future directions · hedged
- Interpretationcitation
Chronic invalidation of individuals with atypAN due to their relatively higher BMI may contribute to the heightened emotional difficulties seen in this population compared to AN-R.
“Chronic invalidation of individuals with atypAN due to their relatively higher BMI may contribute to the heightened emotional difficulties seen in this population compared to AN-R.”
Quote in the paperNot a substantial claim - Study design and conductown data
Our sample was comprised of mostly white females.
“Further, our sample was comprised of mostly white females”
Quote in the paperNot a substantial claim - Interpretationreasoning
It may be problematic to solely rely on current BMI as a proxy marker of illness.
“suggest that it may be problematic to solely rely on current BMI as a proxy marker of illness”
Quote in the paperSubstantial claim
- Classified as probably not a substantial claim. 18
- May combine two claims. 20
- The quote only partly states this claim. 3
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationEpidemiological research suggests that lifetime prevalence rates of atypAN are double or triple that of AN, and significantly fewer patients with atypAN are admitted to ED treatment centres.
“Although epidemiological research suggests that lifetime prevalence rates of atypAN are double or triple that of AN, significantly fewer patients with atypAN are admitted to ED treatment centres (for a review, see Harrop et al., 2021).”
Quote in the paperNot a substantial claim1 of 1 sources checked- cites Harrop et al., 2021 source
The Results (Aim 2: Prevalence in epidemiological samples; page not provided) say AAN lifetime prevalence was double or triple AN prevalence in half the studies comparing them, not across all studies. The Results on consecutive referrals and admissions say approximately 79% of studies reported more AN than AAN patients, but some found the reverse; the copy does not establish statistical significance for the admission difference. (LLM, conf=0.84)
Experimental — accuracy not yet measured
May combine two claims.
Findingown dataGroups significantly differed on BMI: individuals with atypAN reported the highest BMI, followed by AN-BP and then AN-R.
“Groups significantly differed from each other with regards to BMI: individuals with atypAN reported the highest BMI, followed by AN-BP and then AN-R (Table 2).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAN-R represented 21.0% of all admissions to the residential treatment centre, AN-BP represented 17.9%, and atypAN represented 5.7%.
“AN-R (n = 853) represented 21.0% of all admissions to the residential treatment centre, AN-BP (n = 726) represented 17.9%, and atypAN (n = 231) represented 5.7%.”
Quote in the paperNot a substantial claimThe quote only partly states this claim.
Findingown dataWhen controlling for BMI in addition to ED duration, ED symptom differences between AN-BP and AN-R remained significant.
“When controlling for BMI, significant differences in ED symptoms between AN-BP and AN-R remained significant”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataDuration of illness significantly differed across groups (p < 0.001), whereas age did not (p = 0.092).
“Duration of illness significantly differed across groups (p < 0.001), whereas age did not (p = 0.092; see Supplemental Table 1).”
Quote in the paperSubstantial claimThe quote only partly states this claim.
Findingown dataAnxiety severity (OASIS) was significantly greater in the AN-BP group relative to AN-R when controlling for ED duration.
“Anxiety severity was significantly greater in the AN-BP group relative to AN-R”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataWhen controlling for BMI, differences between AN-R and AN-BP on experiential avoidance remained significant, with AN-BP endorsing greater experiential avoidance than AN-R.
“When BMI was controlled, differences between AN-R and AN-BP groups on anxiety symptoms, depression symptoms, experiential avoidance, and mindfulness remained significant, such that those with AN-BP endorsed greater anxiety, depressive, and experiential avoidance symptoms than AN-R (Supplemental Table 3).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataIndividuals with AN-BP reported greater purging than individuals with AN-R, but not atypAN.
“Individuals with AN-BP also reported greater purging than individuals with AN-R, but not atypAN (Supplemental Table 1).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataWhen controlling for BMI, differences between AN-R and AN-BP on depressive symptoms remained significant, with AN-BP endorsing greater depressive symptoms than AN-R.
“When BMI was controlled, differences between AN-R and AN-BP groups on anxiety symptoms, depression symptoms, experiential avoidance, and mindfulness remained significant, such that those with AN-BP endorsed greater anxiety, depressive, and experiential avoidance symptoms than AN-R (Supplemental Table 3).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataWhen controlling for BMI, differences between AN-R and AN-BP on anxiety symptoms remained significant, with AN-BP endorsing greater anxiety than AN-R.
“When BMI was controlled, differences between AN-R and AN-BP groups on anxiety symptoms, depression symptoms, experiential avoidance, and mindfulness remained significant, such that those with AN-BP endorsed greater anxiety, depressive, and experiential avoidance symptoms than AN-R (Supplemental Table 3).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataWhen controlling for BMI in addition to ED duration, ED symptom differences between AN-BP and atypAN became significant, with AN-BP endorsing greater ED psychopathology than atypAN.
“differences between AN-BP and atypAN became significant such that individuals with AN-BP endorsed significantly greater ED psychopathology than those with atypAN and AN-R.”
Quote in the paperSubstantial claimMay combine two claims.
FindingreasoningIndividuals with atypAN showed higher levels of depressive symptoms relative to individuals with AN-R but not AN-BP.
“Individuals with atypAN showed higher levels of depressive symptoms relative to individuals with AN-R but not AN-BP”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataThe findings provide a potential explanation for mixed findings in the literature: individuals with atypAN have more severe ED psychopathology than those with AN-R, but similar levels of ED psychopathology as individuals with AN-BP.
“The majority of these studies do not distinguish between AN-R and AN-BP, and our findings provide a potential explanation for mixed findings by suggesting that individuals with atypAN have more severe ED psychopathology than those with AN-R, but similar levels of ED psychopathology as individuals with AN-BP.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataBMI may account for the greater ED-related concerns found in individuals with atypAN, as the significant differences between atypAN and AN-R became non-significant when controlling for BMI.
“When controlling for BMI, the significant differences between atypAN and AN-R became non-significant, suggesting that BMI may account for the greater ED-related concerns found in individuals with atypAN.”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationreasoningAtypAN was similar in behavioural profile to AN-R but not to AN-BP, which might explain why BMI accounted for differences in ED psychopathology between atypAN and AN-R.
“AtypAN was similar in behavioural profile to AN-R but not to AN-BP, which might explain why BMI accounted for differences in ED psychopathology between atypAN and AN-R.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductreasoningDiagnostic procedures in the current study lacked clarity regarding how DSM-5 criteria for atypAN were operationalised.
“One major limitation was a lack of clarity surrounding diagnostic procedures in the current study.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationIndividuals with atypAN exhibit more severe ED concerns, comorbidity, and emotional difficulties than those with AN, yet are less likely to receive treatment.
“However, multiple studies have now shown that individuals with atypAN exhibit more severe ED concerns, comorbidity, and emotional difficulties than those with AN (Walsh et al., 2023), yet are less likely to receive treatment (Harrop et al., 2023).”
Quote in the paperSubstantial claim0 of 2 sources checkedMay combine two claims.
Interpretationown dataAtypAN symptoms may develop and be just as severe as those of AN despite their higher weight.
“AtypAN symptoms may not only develop and be just as severe as those of AN despite their higher weight”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenAll variables were checked for normality and outliers.
“All variables were checked for normality and outliers.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
PremisecitationAtypical AN was introduced in DSM-5 to describe individuals who met all psychological and behavioural criteria for AN, but who, despite significant weight loss, had a BMI within or above the normal weight range.
“'Atypical' AN (atypAN) was introduced in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) to describe individuals who met all of the psychological and behavioural criteria for AN, but who, despite significant weight loss, had a BMI within or above the 'normal' weight range (American Psychiatric Association, 2013).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites American Psychiatric Association, 2013
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
PremisecitationPatients with atypAN experienced greater minimisation and denial of their EDs, as well as overt forms of weight discrimination, in medical care and during inpatient treatment.
“Harrop et al. (2023) found that patients with atypAN experienced greater minimisation and denial of their EDs, as well as overt forms of weight discrimination, in medical care and during inpatient treatment.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Harrop et al., 2023 source
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
InterpretationreasoningThe reality of living in a culture that heavily scrutinises physical appearance and reveres thinness may contribute to heightened depressive symptoms in individuals with atypAN relative to those with AN-R.
“Finally, the reality of living in a culture that heavily scrutinises physical appearance and reveres thinness may contribute to heightened depressive symptoms in individuals with atypAN relative to those with AN-R.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). The quote only partly states this claim.
Study design and conductown dataThe self-report measures used in the current study demonstrated good internal consistency (Cronbach's α = 0.86-0.93).
“Cronbach's α for the EDE-Q in the current study was = 0.93.”
- Also stated in: § 2.2.2 | Centre for Epidemiologic Studies Depression Scale (CES-D) · plain
“Cronbach's α for the CES-D in the current study was = 0.91.”
- Also stated in: § 2.2.3 | Overall Anxiety Severity and Impairment Scale · plain
“Cronbach's α for the OASIS in the current study was = 0.86.”
Quote in the paperNot a substantial claim- Also stated in: § 2.2.2 | Centre for Epidemiologic Studies Depression Scale (CES-D) · plain
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationThe ASI has shown good reliability and validity in clinical samples.
“The ASI has shown good reliability and validity in clinical samples (Rifkin et al., 2015).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Rifkin et al., 2015 source
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationWhen environmental responses ignore or block these needs from being met, situationally-accurate emotions may become paired with helplessness and loss of control.
“When environmental responses ignore or block these needs from being met, situationally-accurate emotions may become paired with helplessness and loss of control (Cardona et al., 2022).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Cardona et al., 2022 source
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
InterpretationreasoningAtypAN symptoms may be exacerbated by weight stigma and invalidation around ED struggles because of their higher weight.
“but may be exacerbated by weight stigma and invalidation around ED struggles because of their higher weight.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataDuration of illness was included as a covariate to adjust for its potential effects on outcome variables.
“In our first set of analyses, we included duration of illness as a covariate to adjust for its potential effects on outcome variables.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationThe BEAQ has shown good reliability and construct and discriminant validity with other measures of emotional functioning.
“The BEAQ has shown good reliability and construct and discriminant validity with other measures of emotional functioning (Gámez et al., 2014).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Gámez et al., 2014 source
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductreasoningBMI (and duration of illness) was included as a covariate in ANCOVAs to help clarify the reason for differences observed when BMI was not controlled.
“We then conducted ANCOVAs with BMI (and duration of illness) as covariates, to help clarify the reason for differences observed in the initial analyses when BMI was not controlled.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataOur sample only comprised of women.
“Additionally, our sample only comprised of women”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
InterpretationreasoningThe sample being mostly white females may be because residential treatment programs are costly and less feasible for individuals without access to financial resources or health insurance.
“which may be because residential treatment programs are costly and less feasible for individuals without access to financial resources or health insurance.”
Quote in the paperNot a substantial claim- Rests on an assumption: Residential treatment programs are costly and less feasible for individuals without access to financial resources or health insurance.
Classified as probably not a substantial claim.
PremisecitationEmaciation, or current BMI, is used as the indicator for ED severity in the DSM-5.
“Emaciation, or current BMI, is used as the indicator for ED severity in the DSM-5 (APA, 2013).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites APA, 2013
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
PremisecitationIndividuals with AN-BP often have higher BMIs and greater levels of ED psychopathology than those with AN-R.
“Because individuals with AN-BP often have higher BMIs and greater levels of ED psychopathology (Reas & Rø, 2018) than those with AN-R”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Reas & Rø, 2018 source
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductreasoningThe finding of elevated psychopathology in individuals with atypAN relative to AN may be due to a potential referral bias, because individuals admitted to the treatment centre with atypAN may have had more severe ED symptoms than both individuals with atypAN not seeking treatment and many with AN-R whose admission was influenced by their low BMI.
“we may have found elevated psychopathology in individuals with atypAN relative to those with AN because of a potential referral bias: individuals admitted to the treatment centre with atypAN, who were not emaciated, may have had more severe ED symptoms than both individuals with atypAN not seeking treatment and many with AN-R whose admission was influenced by their low BMI.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationEmotions serve an adaptive function by signalling important information about one's needs.
“According to Cardona et al. (2022)'s model of chronic invalidation as a pathway to emotion dysregulation, emotions serve an adaptive function by signalling important information about one's needs.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Cardona et al., 2022 source
Classified as probably not a substantial claim. May combine two claims.
PremisecitationThe DSM-5 does not provide a specific BMI cut-off for AN, but states that a BMI of 18.5 kg/m2 is the lower limit of normal body weight for adults, suggesting that a BMI equal to or greater than 18.5 kg/m2 would not be considered significantly low.
“While the DSM-5 does not provide a specific BMI cut-off, it states that the Centres for Disease Control and Prevention and the World Health Organisation use a BMI of 18.5 kg/m 2 as the lower limit of normal body weight for adults, suggesting that a BMI equal to or greater than 18.5 kg/m 2 would not be considered significantly low.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites American Psychiatric Association, 2013
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
The paper relies on this without support.
Residential treatment programs are costly and less feasible for individuals without access to financial resources or health insurance.
“which may be because residential treatment programs are costly and less feasible for individuals without access to financial resources or health insurance.”
The paper relies on this without support.
Insurance companies often do not cover treatment for individuals with AN who do not meet the 'underweight' cutoff.
“Insurance companies often do not cover treatment for individuals with AN who do not meet the 'underweight' cutoff”
The paper relies on this without support.
The lack of streamlining and clarity of diagnostic procedures is one of the factors hampering research on atypAN.
“the lack of streamlining and clarity of diagnostic procedures is one of the factors hampering research on atypAN.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
BMI-adjusted anxiety-sensitivity difference is reported as both absent and significant
MajorThe abstract says no previously significant difference between atypAN and AN-R remained after controlling for BMI. The results instead say their anxiety-sensitivity difference remained significant, consistent with Table 3.
“When controlling for BMI, all previously significant differences between atypAN and AN-R did not remain significant.”
“When controlling for BMI, differences between AN-R and atypAN for anxiety sensitivity remained significant, but differences between AN-R and AN-BP did not.”
Not every AN-BP versus AN-R difference persisted after BMI adjustment
MinorThe discussion says the emotional-characteristic differences between AN-BP and AN-R remained significant. The results specifically say their anxiety-sensitivity difference did not remain significant.
“When controlling for BMI, differences in ED symptoms and emotional characteristics between AN-BP and AN-R remained significant, but differences between atypAN and AN-R did not.”
“When controlling for BMI, differences between AN-R and atypAN for anxiety sensitivity remained significant, but differences between AN-R and AN-BP did not.”
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Flagged first, then by citations
Research works printed but not linked: 1
- Fairburn C. G., 2008, Cognitive behavior therapy and eating disorders (pp. xii, 324)
Cited by
Sorted by citations
Taking a Deeper Dive Into OSFED Subtypes: A Meta‐Analysis and Systematic Review
Dang, T. B., Hughes, E. K., Dang, A. B., Lai, H. Y., Lee, J., Liu, S., Portingale, J., Fuller‐Tyszkiewicz, M., & Krug, I. (2024) · International Journal of Eating Disorders · doi:10.1002/eat.24280 · Cited by 16 · see citing works
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“For example, Wong and Lowe [35] found that any differences in general symptoms, such as depressive and anxiety symptoms, between AAN and AN, restricting subtype groups did not remain significant when controlling for BMI.”
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Lee, V., Hagan, K. E., & Walsh, B. T. (2026) · International Journal of Eating Disorders · doi:10.1002/eat.70182
Auger, É., Bigot, A., Bukowski, H., Doba, K., Constant, E., & Nandrino, J. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.05.032
Atypical (Other or Unspecified) Feeding or Eating Disorders
Steiger, H., & Booij, L. (2025) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2025.08.003
Friedman, J. I., & Lowe, M. R. (2024) · European Eating Disorders Review · doi:10.1002/erv.3162
Self-citation
- Authors
- Wong, V. Z., & Lowe, M. R.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Drexel University (US)
- Corresponding author
- Lowe, Michael R.
- Venue
- European Eating Disorders Review
- Publisher
- Wiley
- Published
- 2024-02-21
- Volume
- 32
- Issue
- 4
- Pages
- 641-651
- ISSN
- 1072-4133 (ISSN-L)
- 1099-0968
- OpenAlex
- W4392057526
- Cited by
- 9
- References
- 58
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Eating Disorders Review (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- atypical anorexia nervosa, anorexia nervosa subtypes, body mass index, diagnostic classification, eating disorder symptoms, depressive symptoms, anxiety symptoms, anxiety sensitivity, experiential avoidance, mindfulness, female patients, residential treatment
- MeSH terms
- Adolescent, Adult, Anorexia Nervosa, Anxiety, Body Weight, Depression, Female, Humans, Residential Treatment, Body Mass Index, Young Adult
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