The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Analysis of exosome release and its prognostic value in human colorectal cancer
Abstract
A significant proportion of extracellular nucleic acids in plasma circulate highly protected in tumor‐specific exosomes, but it is unclear how the release of exosomes is modulated in carcinogenesis. We quantified by cytometry exosomes in plasma of 91 colorectal cancer patients to evaluate their potential as a tumor indicator and their repercussions on diagnosis and prognosis. We examined the involvement of TSAP6, a TP53‐regulated gene involved in the regulation of vesicular secretion, in levels of circulating exosomes in plasma of colorectal patients and in HCT116 TP53‐(wild‐type and null) human colorectal cancer cell lines. The fraction of exosomes in cancer patients was statistically higher than in healthy controls (mean rank = 53.93 vs. 24.35). High levels of exosomes in plasma of patients correlated with high levels of carcino‐embryonic antigen (P = 0.029) and with poorly differentiated tumors (P = 0.039) and tended to have shorter overall survival than patients with low levels (P = 0.056). Release of exosomes did not correlate with TSAP6 expression; and regulation of TSAP6 by TP53 was not shown either in tumor samples or in HCT116 cell lines. Although it was not suggested that the TP53/TSAP6 pathway regulates the release of exosomes into the plasma of colorectal cancer patients, the level of circulating exosomes may be used as a tumor indicator, because it correlates with poor prognosis parameters and shorter survival. © 2011 Wiley Periodicals, Inc.
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Membrane vesicles as conveyors of immune responses
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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
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Rab27a and Rab27b control different steps of the exosome secretion pathway
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ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles
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Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880
Exosomes in tumor microenvironment influence cancer progression and metastasis
Kahlert, C., & Kalluri, R. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1020-6 · Cited by 872
Exosomes in bodily fluids are a highly stable resource of disease biomarkers
Boukouris, S., & Mathivanan, S. (2015) · PROTEOMICS – Clinical Applications · doi:10.1002/prca.201400114 · Cited by 586
Role of exosomal proteins in cancer diagnosis
Li, W., Li, C., Zhou, T., Liu, X., Liu, X., Li, X., & Chen, D. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0706-8 · Cited by 447
Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers
Thompson, A. G., Gray, E., Heman-Ackah, S. M., Mäger, I., Talbot, K., Andaloussi, S. E., Wood, M. J., & Turner, M. R. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.68 · Cited by 431
Metadata
- Authors
- Silva, J., Garcia, V., Rodriguez, M., Compte, M., Cisneros, E., Veguillas, P., Garcia, J. M., Dominguez, G., Campos‐Martin, Y., Cuevas, J., Peña, C., Herrera, M., Diaz, R., Mohammed, N., & Bonilla, F.
- Venue
- Genes, Chromosomes and Cancer
- Publisher
- Wiley
- Published
- 2011-12-22
- Volume
- 51
- Issue
- 4
- Pages
- 409-418
- ISSN
- 1045-2257 (ISSN-L)
- 1098-2264
- OpenAlex
- W2160436654
- Cited by
- 287
- References
- 29
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Silva, J., Garcia, V., Rodriguez, M., Compte, M., Cisneros, E., Veguillas, P., Garcia, J. M., Dominguez, G., Campos‐Martin, Y., Cuevas, J., Peña, C., Herrera, M., Diaz, R., Mohammed, N., & Bonilla, F. (2012). Analysis of exosome release and its prognostic value in human colorectal cancer. Genes, Chromosomes and Cancer. https://doi.org/10.1002/gcc.21926
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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