Apolipoprotein E4 allele and Alzheimer disease: Examination of Allelic association and effect on age at onset in both early‐and late‐onset cases

Locke, P. A.; Conneally, P. M.; Tanzi, R. E.; Gusella, J. F.; Haines, J. L.

doi:10.1002/gepi.1370120108

Cited by 75Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

Apolipoprotein E4 allele and Alzheimer disease: Examination of Allelic association and effect on age at onset in both early‐and late‐onset cases

Locke, P. A., Conneally, P. M., Tanzi, R. E., Gusella, J. F., Haines, J. L.·1995·Genetic Epidemiology

DOI 10.1002/gepi.1370120108

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Abstract

An increased frequency of the apolipoprotein E type 4 allele (APOE‐4) has previously been associated with both late‐onset sporadic and late‐onset familial Alzheimer disease (AD) [Strittmatter et al. (1993) Proc Natl Acad Sci USA 90:1977–1981; Saunders et al. (1993a) Neurology 43:1467–1472]. To further investigate this association we genotyped affected individuals from 92 separate AD pedigrees including both early‐ and late‐onset cases. An increased frequency of the APOE‐4 allele was found only among the late‐onset cases, both familial and sporadic, confirming the earlier reports. In addition, age at onset was significantly decreased in the APOE‐4 homozygotes (in late onset families) compared to either APOE‐4 heterozygotes or individuals not carrying an APOE‐4 allele. We also observed a significantly decreased frequency of the APOE‐2 allele in both the early‐and late‐onset familial cases. These results strengthen the argument for a direct role of APOE in susceptibility to AD. © Wiley‐Liss, Inc.

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APOEε4 modifies the age at onset in both EOAD and LOAD.
“APOEε4 has been shown to modify the age at onset in both EOAD and LOAD [64–66].”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [66]

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Authors: Locke, P. A., Conneally, P. M., Tanzi, R. E., Gusella, J. F., & Haines, J. L.
Affiliations: Massachusetts General Hospital (US)
Indiana University (US)
Corresponding author: Haines, J. L.
ORCID: Tanzi, R. E.
Gusella, J. F.
Haines, J. L.
Venue: Genetic Epidemiology
Publisher: Wiley
Published: 1995-01
Volume: 12
Issue: 1
Pages: 83-92
ISSN: 0741-0395 (ISSN-L)
1098-2272
DOI: 10.1002/gepi.1370120108
OpenAlex: W1892157526
Cited by: 75
References: 39
Citations by year: 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2015: 1 · 2012: 2
FWCI: 7.09
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3806 d)
Locations: Genetic Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (U24AG021886)
National Institute of Neurological Disorders and Stroke (NS31 153, R01NS031153)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: APOE ε4, Alzheimer's disease, age of onset, familial Alzheimer's disease, sporadic Alzheimer's disease, genetic susceptibility, genetic association
MeSH terms: Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Apolipoproteins E, Gene Frequency, Genotype, Humans, Lod Score, Middle Aged, Pedigree, Case-Control Studies, Age of Onset, Genetic Predisposition to Disease, Apolipoprotein E4

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Apolipoprotein E4 allele and Alzheimer disease: Examination of Allelic association and effect on age at onset in both early‐and late‐onset cases

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