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Armada‐Moreira, A., Gomes, J. I., Pina, C. C., Savchak, O. K., Gonçalves‐Ribeiro, J., Rei, N., Pinto, S., Morais, T. P., Martins, R. S., Ribeiro, F. F., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00090 · Cited by 323 · see citing works

Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes

Lee, S., Su, Z. Z., Emdad, L., Gupta, P., Sarkar, D., Borjabad, A., Volsky, D. J., & Fisher, P. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707697200 · Cited by 318 · see citing works

Variations in Promoter Activity Reveal a Differential Expression and Physiology of Glutamate Transporters by Glia in the Developing and Mature CNS

Regan, M. R., Huang, Y. H., Kim, Y., Dykes‐Hoberg, M., Jin, L., Watkins, A. M., Bergles, D. E., & Rothstein, J. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0790-07.2007 · Cited by 314 · see citing works

Neurotransmitter transporters: molecular function of important drug targets.

Gether, U., Andersen, P., Larsson, O. M., & Schousboe, A. (2006) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.05.003 · Cited by 319 · see citing works

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

Hoecke, A. V., Schoonaert, L., Lemmens, R., Timmers, M., Staats, K. A., Laird, A. S., Peeters, E., Philips, T., Goris, A., Dubois, B., et al. (2012) · Nature Medicine · doi:10.1038/nm.2901 · Cited by 304 · see citing works

Glutamate Transporters and the Excitotoxic Path to Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis

Foran, E., & Trotti, D. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2444 · Cited by 300 · see citing works

Functional changes in astroglial cells in epilepsy

Binder, D. K., & Steinhäuser, C. (2006) · Glia · doi:10.1002/glia.20394 · Cited by 299 · see citing works

History of antimicrobial drug discovery: Major classes and health impact

Aminov, R. I. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.10.001 · Cited by 305 · see citing works

Rodent Models of Amyotrophic Lateral Sclerosis

Philips, T., & Rothstein, J. D. (2015) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0567s69 · Cited by 292 · see citing works

Glutamate and the biology of gliomas

de Groot, J., & Sontheimer, H. W. (2010) · Glia · doi:10.1002/glia.21113 · Cited by 290 · see citing works

A clinical drug library screen identifies astemizole as an antimalarial agent

Chong, C. R., Chen, X., Shi, L., Liu, J. O., & Sullivan, D. J. (2006) · Nature Chemical Biology · doi:10.1038/nchembio806 · Cited by 291 · see citing works

Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

Mitsumoto, H., Brooks, B. R., & Silani, V. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70129-2 · Cited by 291 · see citing works

Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1

Kang, D., Su, Z.-Z., Sarkar, D., Emdad, L., Volsky, D. J., & Fisher, P. B. (2005) · Gene · doi:10.1016/j.gene.2005.04.006 · Cited by 287 · see citing works

Astrocyte dysfunction in epilepsy

Seifert, G., Carmignoto, G., & Steinhäuser, C. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.004 · Cited by 287 · see citing works

The Harms and Benefits of Inflammatory and Immune Responses in Vascular Disease

Chamorro, Á., & Hallenbeck, J. M. (2006) · Stroke · doi:10.1161/01.str.0000200561.69611.f8 · Cited by 284 · see citing works

Calcium dysregulation in amyotrophic lateral sclerosis

Großkreutz, J., Bosch, L. V. D., & Keller, B. U. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.002 · Cited by 284 · see citing works

Reduced oxidative damage in ALS by high‐dose enteral melatonin treatment

Weishaupt, J. H., Bartels, C., Pölking, E., Dietrich, J., Rohde, G., Pöeggeler, B., Mertens, N., Sperling, S., Bohn, M., Huether, G., et al. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00377.x · Cited by 284 · see citing works

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

Miller, B. R., Dorner, J. L., Shou, M., Sari, Y., Barton, S. J., Sengelaub, D. R., Kennedy, R. T., & Rebec, G. V. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.004 · Cited by 280 · see citing works

Selective Dysfunction of Hippocampal CA1 Astrocytes Contributes to Delayed Neuronal Damage after Transient Forebrain Ischemia

Ouyang, Y., Voloboueva, L. A., Xu, L., & Giffard, R. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0211-07.2007 · Cited by 279 · see citing works

Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design

Bahr, G., González, L. J., & Vila, A. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00138 · Cited by 284 · see citing works

FTD and ALS: A Tale of Two Diseases

Ferrari, R., Kapogiannis, D., Huey, E. D., & Momeni, P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795563700 · Cited by 270 · see citing works

Alterations of the Host Microbiome Affect Behavioral Responses to Cocaine

Kiraly, D. D., Walker, D. M., Calipari, E. S., Labonté, B., Issler, O., Peña, C. J., Ribeiro, E., Russo, S. J., & Nestler, E. J. (2016) · Scientific Reports · doi:10.1038/srep35455 · Cited by 264 · see citing works

Riluzole, Neuroprotection and Amyotrophic Lateral Sclerosis

Cheah, B. C., Vucic, S., Krishnan, A. V., & Kiernan, M. C. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791163939 · Cited by 260 · see citing works

Excitotoxic damage to white matter

Matute, C., Alberdi, E. M., Domercq, M., Sánchez‐Gómez, M. V., Pérez‐Samartín, A., Antigüedad, A. R., & Pérez‐Cerdá, F. (2007) · Journal of Anatomy · doi:10.1111/j.1469-7580.2007.00733.x · Cited by 259 · see citing works

Modulation of Neural Plasticity as a Basis for Stroke Rehabilitation

Pekna, M., Pekny, M., & Nilsson, M. (2012) · Stroke · doi:10.1161/strokeaha.112.654228 · Cited by 258 · see citing works

Glial cells in amyotrophic lateral sclerosis

Philips, T., & Rothstein, J. D. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.05.015 · Cited by 255 · see citing works

Astrocyte energy and neurotransmitter metabolism in Alzheimer’s disease: Integration of the glutamate/GABA-glutamine cycle

Andersen, J. V., Schousboe, A., & Verkhratsky, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102331 · Cited by 259 · see citing works

Active and passive immunotherapy for neurodegenerative disorders

Brody, D. L., & Holtzman, D. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125529 · Cited by 250 · see citing works

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

Verkhratsky, A., Sofroniew, M. V., Messing, A., deLanerolle, N. C., Rempe, D. A., Rodriguez, J. J., & Nedergaard, M. (2012) · ASN NEURO · doi:10.1042/an20120010 · Cited by 247 · see citing works

Human astrocytes in the diseased brain

Dossi, E., Vasile, F., & Rouach, N. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.02.001 · Cited by 250 · see citing works

Alexander Disease

Messing, A., Brenner, M., Feany, M. B., Nedergaard, M., & Goldman, J. E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5384-11.2012 · Cited by 250 · see citing works

Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial

Cudkowicz, M., Titus, S., Kearney, M., Yu, H., Sherman, A., Schoenfeld, D., Hayden, D., Shui, A. M., Brooks, B. R., CONWIT, R. A., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70222-4 · Cited by 243 · see citing works

Research Highlights

(2005) · Nature Medicine · doi:10.1038/nm0205-125

Surprise neuroprotective potential of β-lactam antibiotics

Senior, K. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03385-4

β-Lactams as Neuroprotective Agents

Konaklieva, M. I., Plotkin, B. J., & Herbert, T. (2009) · Anti-Infective Agents · doi:10.2174/187152109787047823 · Cited by 6 · see citing works

Glutamate Transporter: An Unexpected Target for Some Antibiotics

Mao, J. (2005) · Molecular Pain · doi:10.1186/1744-8069-1-5 · Cited by 18 · see citing works

ANTIBIOTICS PROTECT NEURONS

ROVNER, S. L. (2005) · Chemical & Engineering News · doi:10.1021/cen-v083n002.p008a