Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors
Abstract
The floor plate (FP), a signaling center and a structure rich in radial glia-like cells, has been traditionally thought to be devoid of neurons and neuronal progenitors. However, in the midbrain, the FP contains neurons of the dopaminergic (DA) lineage that require contact with radial glia-like cells for their induction. We, therefore, decided to explore the interaction relationship between radial glia and neurons during DA neurogenesis. Taking advantage of a novel FP radial glia-like cell culture system and retroviruses, DA neurons were lineage traced in vitro. In utero BrdU pulse-chases extensively labeled the midbrain FP and traced DA neurons both in vivo and in FP cultures. Moreover, from E9.5 to E13.5 the midbrain FP contained dividing cells only in the most apical part of the neuroepithelium, in cells identified as radial glia-like cells. We, therefore, hypothesized that midbrain FP radial glia-like cells could be DA progenitors and tested our hypothesis in vivo. Lineage tracing of DA progenitors with EGFP in Tis21-EGFP knock-in mice, and genetic fate mapping in GLAST::CreERT2/ZEG mice identified the neuroepithelium of the midbrain FP, and specifically, GLAST+ radial glia-like cells as DA progenitors. Combined, our experiments support the concept that the midbrain FP differs from other FP regions and demonstrate that FP radial glia-like cells in the midbrain are neurogenic and give rise to midbrain DA neurons.
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Midbrain dopamine neurons originate from the mesodiencephalic floorplate, a region at the ventral midline defined by Shh+ and Foxa2+ expression.
“These neurons originate from the mesodiencephalic floorplate (FP), a region at the ventral midline defined by the mRNA expression of Shh+ and Foxa2+ [67–73].”
From Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches (2020) · cites this paper as [73]
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- Authors
- Bonilla, S., Hall, A. C., Pinto, L., Attardo, A., Götz, M., Huttner, W. B., & Arenas, E.
- Affiliations
- Karolinska Institutet (SE)
- Max Planck Institute of Molecular Cell Biology and Genetics (DE)
- Helmholtz Munich (DE)
- Corresponding author
- Arenas, Ernest
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2008-03-19
- Volume
- 56
- Issue
- 8
- Pages
- 809-820
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2105643617
- Cited by
- 136
- References
- 49
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 13 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 14
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Site cant be reached (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- radial glia-like cells, dopaminergic neurons, dopaminergic neurogenesis, lineage tracing, GLAST, TIS21, neuroepithelium, fate mapping, midbrain development
- MeSH terms
- Age Factors, Animals, Bromodeoxyuridine, Cell Differentiation, Cells, Cultured, Dopamine, Embryo, Mammalian, Estrogen Antagonists, Female, Mesencephalon, Mice, Inbred C57BL, Mice, Transgenic, Neuroglia, Pregnancy, Tamoxifen, Genes, Tumor Suppressor, Immediate-Early Proteins, Gene Expression Regulation, Developmental, Body Patterning, Tumor Suppressor Proteins, Excitatory Amino Acid Transporter 1, Green Fluorescent Proteins, Mice, Embryonic Stem Cells
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