The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Aquaporin‐4 and epilepsy
Abstract
Recent studies have implicated glial cells in modulation of synaptic transmission, so it is plausible that glial cells may have a functional role in the hyperexcitability characteristic of epilepsy. Indeed, alterations in distinct astrocyte membrane channels, receptors, and transporters have all been associated with the epileptic state. This review focuses on the potential roles of the glial water channel aquaporin‐4 (AQP4) in modulation of brain excitability and in epilepsy. We will review studies of mice lacking AQP4 (Aqp4−/− mice) or α‐syntrophin (an AQP4 anchoring protein) and discuss the available human studies demonstrating alterations of AQP4 in human epilepsy tissue specimens. We will conclude with new studies of AQP4 regulation and discuss the potential role of AQP4 in the development of epilepsy (epileptogenesis). While many questions remain unanswered, the available data indicate that AQP4 and its molecular partners may represent important new therapeutic targets. © 2012 Wiley Periodicals, Inc.
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Cites
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334
The tripartite synapse: roles for gliotransmission in health and disease
Halassa, M. M., Fellin, T., & Haydon, P. G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.005 · Cited by 852
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy
Rigau, V., Morin, M., Rousset, M.-C., de Bock, F., Lebrun, A., Coubes, P., Picot, M.-C., Baldy-Moulinier, M., Bockaert, J., Crespel, A., et al. (2007) · Brain · doi:10.1093/brain/awm118 · Cited by 429
Estimating risk for developing epilepsy: A population-based study in Rochester, Minnesota
Hesdorffer, D. C., Logroscino, G., Benn, E. K. T., Katri, N., Cascino, G., & Hauser, W. A. (2011) · Neurology · doi:10.1212/wnl.0b013e318204a36a · Cited by 324
Critical role of aquaporin-4 (AQP4) in astrocytic Ca 2+ signaling events elicited by cerebral edema
Thrane, A. S., Rappold, P. M., Fujita, T., Torres, A., Bekar, L. K., Takano, T., Peng, W., Wang, F., Rangroo Thrane, V., Enger, R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015217108 · Cited by 254
Self-citationPhysiological Evidence That Pyramidal Neurons Lack Functional Water Channels
Andrew, R. D., Labron, M. W., Boehnke, S. E., Carnduff, L., & Kirov, S. A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk032 · Cited by 179
Febrile seizures and mechanisms of epileptogenesis: insights from an animal model
Bender, R. A., Dubé, C., & Baram, T. Z. (2004) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4757-6376-8_15 · Cited by 83
Cited by
Physiological Roles of Aquaporin-4 in Brain
Nagelhus, E. A., & Ottersen, O. P. (2013) · Physiological Reviews · doi:10.1152/physrev.00011.2013 · Cited by 766
Self-citationDeletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
Xu, Z., Xiao, N., Chen, Y., Huang, H., Marshall, C., Gao, J., Cai, Z., Wu, T., Hu, G., & Xiao, M. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0056-1 · Cited by 500
Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain
Sosunov, A. A., Wu, X., Tsankova, N. M., Guilfoyle, E., McKhann, G. M., & Goldman, J. E. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4037-13.2014 · Cited by 185
mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment
Ravizza, T., Scheper, M., Di Sapia, R., Gorter, J., Aronica, E., & Vezzani, A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-024-00805-1 · Cited by 141
Transmission Disequilibrium of Small CNVs in Simplex Autism
Krumm, N., O’Roak, B. J., Karakoc, E., Mohajeri, K., Nelson, B., Vives, L., Jacquemont, S., Munson, J., Bernier, R., & Eichler, E. E. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.07.024 · Cited by 113
Metadata
- Authors
- Binder, D. K., Nagelhus, E. A., & Ottersen, O. P.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2012-02-29
- Volume
- 60
- Issue
- 8
- Pages
- 1203-1214
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W1983941387
- Cited by
- 171
- References
- 7
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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